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Article Citation - WoS: 4Citation - Scopus: 4Neuroprotective effects of adrenomedullin in experimental traumatic brain injury model in rats(Turkish Assoc Trauma Emergency Surgery, 2022) Emmez, Gokcen; Bulduk, Erkut Baha; Yildirim, ZuhalBACKGROUND: Traumatic brain injuries cause damages in the brain in several ways, which include cell death because of edema, disruption of the blood-brain barrier, shear stress, and ischemia. In this study, we investigated the effects of adrenomedullin (AM) on oxidative stress and inflammation after head traumas in a rat model. METHODS: Eighteen male adult Wistar albino rats were randomized into three groups (n=6). No traumas were applied to the control (C) group. Traumas were applied in line with Marmarau trauma model in the trauma group. The rats in the AM treatment group were treated with post-traumatic 12 mu g/kg i.p. AM in addition to the trauma group. The rats were followed for 7 days in all groups and were then sacrificed. Brain tissues and blood samples were taken. RESULTS: In the trauma group, both tissue and serum MDA, TNF-alpha, and IL-6 levels were significantly increased compared to the control group (p<0.05). In the AM-treated group, serum TNF-alpha levels were significantly decreased compared to the trauma group (p<0.05). In the trauma group, both tissue and serum GSH levels were significantly decreased compared to the control group (p<0.05). In the trauma group, serum Vitamin D3 levels were significantly decreased compared to the control group (p<0.05). In the AM-treated group, both tissue and serum GSH levels were significantly increased compared to the trauma group (p<0.05). CONCLUSION: These results indicate that AM has neuroprotective effects on traumatic brain injury in a rat model.Article Effects of Total and Subtotal Glial Tumor Resection on Survival(2020) Ercan, Serdar; Ataizi, Zeki S; Ataizi, Fulya; Bulduk, Erkut BahaObjectives: Glial tumors are treated with a multidisciplinary team approach including specialists in brain surgery, radiology, pathology, radiation oncology and medical oncology. Surgery is one of the main treatment options. However,the effect of resection volume on prognosis is still uncertain. The aim of this study is to investigate the relationshipbetween the residual tumor volume and survival of the patients who were operated with the diagnosis of intracranialglial tumor in the last 5 years.Methods: Of 49 patients, 30 underwent total resection and 19 underwent subtotal resection.Results: The average surveys of total resection were 13.6 (6-32 months) months. 4 of 6 patients with anaplastic astrocytoma survived and the mean survey was 26.5 (4-45) months. The survey of subtotal resection group was significantlyshorter than the other TR group.Conclusion: As a result, recovery was inversely increased with residual tumor volume
