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Author: Balci, BurcuWoS Q: Q1

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    Catalyst-Free Synthesis of Thiourea-Linked Dumbbell-Shaped POSS for Ultrasensitive Determination of Prilocaine in Human Blood With Computational Insights
    (Elsevier, 2026) Bilge, Selva; Bayraktar, Ece Nur; Erkmen, Cem; Balci, Burcu; Abofoul, Anas; Ozkut, Merve Icli; Cihaner, Atilla
    Although various electrochemical sensors have been reported for the determination of local anesthetic drugs, most existing platforms suffer from limited sensitivity, insufficient surface stability, or inadequate electron-transfer efficiency, particularly when applied to complex biological matrices. Moreover, the potential of hybrid polyhedral oligomeric silsesquioxane (POSS)-based nanostructures combined with metal oxide nano-particles for improving electroanalytical performance has not yet been thoroughly explored. In this study, a high-sensitivity electrochemical nanosensor was developed for the determination of prilocaine (PC), an amide-type local anesthetic, using a glassy carbon (GC) electrode modified with POSS-titanium dioxide (TiO2) nano-particles (Nps). The combination of modifications provided a unique electrode surface by combining the high stability of POSS with the strong adsorption properties of TiO2 Nps, thereby increasing both surface loading and adsorption capacity. To elucidate the structure of the modification combination, 1H and 13C nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) spectroscopic techniques, as well as Brunauer-Emmett-Teller (BET), X-Ray diffraction (XRD), Electrochemical impedance spectroscopy (EIS), and high-resolution transmission electron microscopy (HRTEM) analysis techniques were used, respectively. The analytical performance of the developed nanosensor was systematically optimized using differential pulse voltammetry (DPV), adsorptive stripping differential pulse voltammetry (AdSDPV), square wave voltammetry (SWV), and adsorptive stripping square wave voltammetry (AdSSWV) techniques. As a result of the optimization studies, the lowest limit of detection (LOD) was 3.66 x 10-8 M with the AdSSWV technique. DFT results corroborated the mechanism, indicating ring-centered electron donation (HOMO) and adsorption-favored N/O regions (MEP). Low LOD values were also recorded with other techniques, demonstrating the method's high sensitivity in analyte detection. In real sample analysis tests, PC recovery value in human blood samples was determined to be 98.69% using the AdSDPV technique. Despite the matrix effect, the nanosensor demonstrated high accuracy and reproducibility. The results indicate that the developed POSS-TiO2 Nps modified GC electrode sensor offers a high-performance, reliable, and good electrochemical detection platform suitable for use in biological and clinical applications.
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    Synthesis and Electropolymerization of a Selenophene Based Chemiluminescent Monomer and Its Use in Blood Detection
    (Elsevier Sci Ltd, 2025) Balci, Burcu; Cakal, Deniz; Cihaner, Atilla
    A new selenophene based trimeric chemiluminescent compound, namely 5,7-di(selenophen-2-yl)-2,3-dihydrothieno[3,4-d]pyridazine-1,4-dione (S2T-Lum), was synthesized in two steps via electron donor-acceptor-donor approach. Its chemiluminescent reaction with hydrogen peroxide was investigated in an alkaline solution in the presence of various catalysts such as different metal ions, hemin and blood samples and the results were compared with its thiophene analogue (T2T-Lum) and luminol. It was found that S2T-Lum was very sensitive to copper(II) and iron(III) ions, and blood samples. Also, it can be easily concluded that S2T-Lum as a new member of luminol type compounds is a potential candidate for the detection of blood findings in forensic science. Furthermore, S2T-Lum has an irreversible oxidation peak at 1.28 V vs Ag/AgCl, which is responsible from its electropolymerization. S2T-Lum was successfully polymerized electrochemically via potentiodynamic electrolysis without cleavage of its chemiluminescent active appendage. To the best of our knowledge, its corresponding polymer PS2T-Lum film is the first member of selenophene based luminol type electroactive polymers.
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    Article
    Citation - WoS: 16
    Citation - Scopus: 16
    Electrochemical and Optical Characterization of a Multielectrochromic Copolymer Based on 3,4-Ethylenedioxythiophene and Functionalized Dithienylpyrrole Derivative
    (Pergamon-elsevier Science Ltd, 2019) Tutuncu, Esra; Ozkut, Merve Icli; Balci, Burcu; Berk, Hasan; Cihaner, Atilla; Icli Ozkut, Merve
    A novel conjugated copolymer, namely poly(3,4-ethylenedioxythiophene-co-1-(3,5-bis(trifluoromethyl)phenyl)-2,5-di(thiophen-2-yl)-1H-pyrrole) (P(EDOT-co-1)) was synthesized via electropolymerization method from a mixture of 3,4-ethylenedioxythiophene and 1-(3,5-bis(trifluoromethyl)phenyl)-2,5-di(thiophen-2-yl)-1H-pyrrole comonomers. The corresponding copolymer has an optical band gap of 1.7 eV and 41% optical contrast at 525 nm with a coloration efficiency of 258 cm(2)/C and 1.4 s switching time. The copolymer has a multi-electrochromic behavior: It has dark purple, purple, gray, green and cyan colors at different oxidation states. Electrochemical stability of P(EDOT-co-1) copolymer was also investigated and it was observed that the copolymer retained 86% of its stability under ambient conditions in the presence of oxygen (without purging the electrolyte solution with any inert gas) according to the current density and 83% according to the deposited charge even after 1000 redox cycles.