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Author: Aydin, CansetPublisher: Springer

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    Article
    Citation - WoS: 12
    Citation - Scopus: 15
    Comparison of Cervical and Ocular Vestibular-Evoked Myogenic Potential Responses Between Tone Burst Versus Chirp Stimulation
    (Springer, 2021) Aydin, Canset; Onay, Ovsen; Tezcan, Elif Ilkay; Askar, Zuhal; Ozdek, Ali
    Purpose To compare the effectiveness of chirp and tone burst stimuli in oVEMP and cVEMP testing for healthy adults Methods This study was conducted in 56 healthy volunteers (112 ears). Ocular and cervical VEMP (oVEMP, cVEMP) tests were performed for each participant using tone burst and chirp stimuli. VEMP response rates, latency of each peak (p1-n1, n1-p1), peak to peak amplitude (p1-n1 amplitude and n1-p1 amplitude), and rectified amplitudes were measured and compared between these two different stimuli. Results VEMP response rates with chirp stimuli are higher than the tone burst stimuli for both cVEMP and oVEMP tests (The difference was statistically significant for oVEMP, p = 0.001). Chirp stimuli have higher p1n1 amplitude and rectified amplitude and shorter p1and n1 latency then tone burst stimuli for cVEMP (p = 0.015, p = 0.007, p < 0.001, p < 0.001, respectively). Chirp stimuli also have higher n1p1 amplitude and shorter n1and p1 latency then tone burst stimuli for oVEMP (p = 0.006, p < 0.001, p < 0.001, respectively). Conclusion The present findings show that the chirp stimulus triggers earlier VEMP responses with higher amplitudes than the tone burst stimulus during cVEMP and oVEMP testing. VEMP response rate with chirp stimulus is also higher than the tone burst. Therefore chirp stimulus can be used in VEMP testing as effectively as, if not more than, tone burst stimulus in clinical practice.
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    Article
    Evaluation of Cochlear Angular Orientation in Patients with CHARGE Syndrome
    (Springer, 2026) Kulekci, Cagri; Eroglu, Ergin; Aydin, Canset; Sennaroglu, Levent
    Purpose This study aimed to evaluate cochlear angulation in patients with CHARGE syndrome and compare it with indi-viduals with normal cochlear anatomy. Methods Eighteen patients with CHARGE syndrome followed for sensorineural hearing loss were retrospectively reviewed and compared with 18 age-matched controls with normal cochlear anatomy. Temporal bone computed tomography (CT) and magnetic resonance imaging were analyzed to assess inner ear malformations and cochlear nerve status. Cochlear angula-tion was measured on axial CT images by calculating the angle formed between lines passing through the basal turns of both cochleae at the level of the round window. Statistical analyses were performed using chi-square and independent samples t-tests. Results Cochlear hypoplasia type III was the most common anomaly in the CHARGE group. Cochlear nerves were fre-quently hypoplastic or absent, whereas all control ears were normal. Mean cochlear angulation was significantly narrower in the CHARGE group compared with controls (94.49 degrees +/- 10.02 degrees vs. 114.02 degrees +/- 8.17 degrees, p < 0.001). Conclusion CHARGE syndrome is associated with significantly altered cochlear angulation, which may contribute to surgi-cal challenges during cochlear implantation. Preoperative recognition of this feature may facilitate safer and more effective surgical planning
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    Article
    Citation - WoS: 9
    Citation - Scopus: 11
    Human Laryngeal Squamous Cell Carcinoma Cell Line Release of Endogenous Anandamide and 2-Arachidonoylglycerol, and Their Antiproliferative Effect Via Exogenous Supplementation: an in Vitro Study
    (Springer, 2022) Onay, Ovsen; Kose, Sevil; Suslu, Nilda; Korkusuz, Petek; Nemutlu, Emirhan; Aydin, Canset; Hosal, Sefik
    The level of the major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are altered in several types of carcinomas, and are known to regulate tumor growth. Thusly, this study hypothesized that the HEp-2 human laryngeal squamous cell carcinoma (LSCC) cell line releases AEA and 2-AG, and aimed to determine if their exogenous supplementation has an anti-proliferative effect in vitro. In this in vitro observational study a commercial human LSCC cell line (HEp-2) was used to test for endogenous AEA and 2-AG release via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The anti-proliferative effect of AEA and 2-AG supplementation was evaluated via WST-1 proliferation assay. It was observed that the HEp-2 LSCC cell line released AEA and 2-AG; the median quantity of AEA released was 15.69 ng mL(-1) (range: 14.55-15.95 ng mL(-1)) and the median quantity of 2-AG released was 2.72 ng (-1) (range: 2.67-2.74 ng mL(-1)). Additionally, both AEA and 2-AG exhibited an anti-proliferative effect. The anti-proliferative effect of 2-AG was stronger than that of AEA. These findings suggest that AEA might function via a CB1 receptor-independent pathway and that 2-AG might function via a CB2-dependent pathway. The present findings show that the HEp-2 LSCC cell line releases the major endocannabinoids AEA and 2-AG, and that their supplementation inhibits tumor cell proliferation in vitro. Thus, cannabinoid ligands might represent novel drug candidates for laryngeal cancers, although functional in vivo studies are required in order to validate their potency.