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Article Citation - WoS: 13Citation - Scopus: 14Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization(Mdpi, 2021) Alazzawi, Marwa; Alsahib, Nabeel Kadim Abid; Sasmazel, Hilal TurkogluGlycine (Gly), which is the simplest amino acid, induces the inflammation response and enhances bone mass density, and particularly its beta polymorph has superior mechanical and piezoelectric properties. Therefore, electrospinning of Gly with any polymer, including polyvinyl alcohol (PVA), has a great potential in biomedical applications, such as guided bone regeneration (GBR) application. However, their application is limited due to a fast degradation rate and undesirable mechanical and physical properties. Therefore, encapsulation of Gly and PVA fiber within a poly(epsilon-caprolactone) (PCL) shell provides a slower degradation rate and improves the mechanical, chemical, and physical properties. A membrane intended for GBR application is a barrier membrane used to guide alveolar bone regeneration by preventing fast-proliferating cells from growing into the bone defect site. In the present work, a core/shell nanofibrous membrane, composed of PCL as shell and PVA:Gly as core, was developed utilizing the coaxial electrospinning technique and characterized morphologically, mechanically, physically, chemically, and thermally. Moreover, the characterization results of the core/shell membrane were compared to monolithic electrospun PCL, PVA, and PVA:Gly fibrous membranes. The results showed that the core-shell membrane appears to be a good candidate for GBR application with a nano-scale fiber of 412 +/- 82 nm and microscale pore size of 6.803 +/- 0.035 mu m. Moreover, the wettability of 47.4 +/- 2.2 degrees contact angle (C.A) and mechanical properties of 135 +/- 3.05 MPa average modulus of elasticity, 4.57 +/- 0.04 MPa average ultimate tensile stress (UTS), and 39.43% +/- 0.58% average elongation at break are desirable and suitable for GBR application. Furthermore, the X-ray diffraction (XRD) and transmission electron microscopy (TEM) results exhibited the formation of beta-Gly.Article Citation - Scopus: 1Biocompatibility of Electrospun Pva-Based Nanocomposite With Chemical Vapor Deposition-Derived Graphene Monolayer(Lukasiewicz Research Network-industrial Chemistry inst, 2024) Sasmazel, Hilal Turkoglu; Alazzawi, Marwa; Sadhu, Verra; Gozutok, MelikeThe biocompatibility of electrospun PVA with monolayer graphene obtained by chemical vapor deposition (PVA/CVD-grown MLG) nanocomposite was investigated. The properties of PVA/ CVD-grown MLG nanocomposite were compared with those of electrospun PVA mat. Raman analysis confirmed the presence of graphene monolayer on PVA. Although no significant changes in tensile properties were observed, the electrical conductivity increased from 0.1 (PVA mat) to 0.4 mu S/cm (PVA/ CVD-grown MLG). Thermal stability was also increased, as evidenced by the higher onset temperature and temperature of maximum decomposition rate determined by TGA. The contact angle decreased slightly, which resulted in higher PBS absorption and degradation of the nanocomposite. Water vapor transmission rate (WVTR) decreased from 40 (PVA mat) to 37 g/m2 h (PVA/CVD-grown MLG). Cell culture studies showed better cell viability, population, and growth in the case of PVA/CVD-grown MLG nanocomposite due to improved physical, chemical and mechanical properties.
