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Article Correlation of Clinical Signs and Magnetic Resonance Imaging Findings in Patients With Lumbar Spondylosis(Turkish League Against Rheumatism, 2023) Altan, Lale; Ökmen, Burcu Metin; Tuncer, Tiraje; Sindel, Dilşad; Çay, Hasan Fatih; Hepgüler, Simin; Uğurlu, Hatice; Gurer, Gülcan; Sarıkaya, Selda; Melikoğlu, Meltem Alkan; Metin Ökmen, Burcu; Ayhan, Fikriye Figen; Duruöz, Mehmet Tuncay; Sezer, IlhanObjectives: The purpose of the study was to contribute further to this debated topic by investigating the correlation of magnetic resonance imaging (MRI) findings with the clinical picture in lumbar spondylosis patients. Patients and methods: This multicenter retrospective study (as part of the epidemiological project of the TLAR-OASG [Turkish League Against Rheumatism-Osteoarthritis Study Group]) included 514 patients (101 males, 413 females; mean age: 63.6±10.8 years; range, 40 to 85 years) who were diagnosed as lumbar spondylosis by clinical examination and direct X-ray between December 2016 and June 2018. Demographic characteristics of patients, Visual Analog Scale for pain, presence of radiating pain, Roland-Morris disability questionnaire, straight leg raise test, deep tendon reflexes, neurogenic intermittent claudication symptoms, any decrease of muscle strength, and abnormality of sensation were recorded. Lumbar MRI findings of the patients were recorded as positive or negative in terms of disc herniation, intervertebral disc degeneration, root compression, osteophytes, spinal stenosis. Statistical analysis was done to assess the correlation between the clinical symptoms, physical examination, and MRI findings. Results: Correlation analysis of the MRI results and the clinical findings showed a significant correlation between straight leg raise test and root compression (p<0.001, r=0.328) and a significant correlation between neurogenic intermittent claudication and spinal stenosis (p<0.001, r=0.376). Roland-Morris disability questionnaire had a significant correlation with all MRI findings (p<0.05, r<0.200). Conclusion: The results of this study corroborate the notion that diligent patient history and physical examination are more valuable than MRI findings, even though a higher incidence of abnormal MRI findings have been obtained in patients with disability and dermatomal radiating pain.Article Citation - WoS: 2Citation - Scopus: 2Regional Variations in Psoriatic Arthritis: Insights From a Nationwide Multicenter Analysis in Türkiye(Turkish League Against Rheumatism, 2024) Kılıç, Erkan; Kılıç, Gamze; Tekeoğlu, İbrahim; Sargın, Betül; Kasman, Sevtap Acer; Alkan, Hakan; Nas, Kemal; Yurdakul, Ozan Volkan; Duruöz, Mehmet Tuncay; Ayhan, Fikriye Figen; Bodur, Hatice; Kandur, Yaşar; Sunar, İsmihanObjectives: The study aimed to investigate and compare clinical features, disease activity, and the overall disease burden among psoriatic arthritis (PsA) patients across seven distinct geographic regions in Türkiye. Patients and methods: A multicenter cross-sectional study involving 1,134 PsA patients from 25 referral centers across seven regions was conducted. Demographic and clinical characteristics, comorbidities, joint involvement, extra-articular manifestations, and disease activity measures were evaluated across regions. Results: A total of 1134 PsA patients from seven different geographic regions in Türkiye participated in this study. The highest number of participants was from the Marmara region (n=409), with subsequent representation from Central Anatolia (n=370), Aegean (n=139), Mediterranean (n=60), Black Sea (n=60), Eastern Anatolia (n=60), and Southeastern Anatolia (n=36) regions. There were significant variations in demographic profile, including age, body mass index, age of disease onset, educational status, comorbidities, and family history of both psoriasis and PsA. Clinical features, such as enthesitis, dactylitis, uveitis, and joint involvement, demonstrated significant variation across regions. Additionally, disease activity measures, including pain, patient and physician global assessments, acute phase reactants, disease activity indices, quality of life, and functional status, displayed considerable regional differences. Conclusion: This nationwide study revealed substantial regional diversity in demographic data, clinical characteristics, disease activity, and quality of life among PsA patients in Türkiye. These findings stress the need to customize treatment approaches to address regional needs and to conduct further research to uncover reasons for disparities. It is crucial to enhance region-specific approaches to improve patient care and outcomes for PsA.Article Citation - WoS: 4Citation - Scopus: 4The Effect of Combined Hydrolyzed Type 2 Collagen, Methylsulfonylmethane, Glucosamine Sulfate and Chondroitin Sulfate Supplementation on Knee Osteoarthritis Symptoms(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2024) Ayhan, Fikriye Figen; Çoban, Ayşegül Demirci; Karasu, Ayça Utkan; Karaoğlan, Belgin; Çınar, Ece; Eyigör, Sibel; Dalyan, Meltem; Kaplan, Başak Mansız; Vural, Secil Pervane; Çakıt, Burcu DuyurObjectives: This study aimed to evaluate the effects of the combined hydrolyzed type 2 collagen, methylsulfonylmethane (MSM), glucosamine sulfate (GS), and chondroitin sulfate (CS) supplement on knee pain intensity in patients with knee osteoarthritis (OA). Patients and methods: This multicenter, observational, noninterventional study included 98 patients (78 females, 20 males; mean age: 52.8±6.5 years; range, 40 to 64 years) who had Grade 1-3 knee OA between May 2022 and November 2022. The patients were prescribed the combination of hydrolyzed type 2 collagen, MSM, GS, and CS as a supplement for knee OA. The sachet form of the combined supplement containing 1250 mg hydrolyzed type 2 collagen, 750 mg MSM, 750 mg GS, and 400 mg CS was used once daily for two consecutive months. Patients were evaluated according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS)-pain, and Health Assessment Questionnaire (HAQ). Patients were scheduled to visit for follow-up four weeks (Visit 2) and eight weeks (Visit 3) after Visit 1 (baseline; day 0 of the study). Results: For the VAS-pain, WOMAC, WOMAC-subscale, and HAQ scores, the differences in improvement between the three visits were significant (p<0.001 for all). The patient compliance with the supplement was a median of 96.77%, both for Visit 2 and Visit 3. Conclusion: The combination of hydrolyzed type 2 collagen, MSM, GS, and CS for eight weeks in knee OA was considered an effective and safe nutritional supplement.Article KALKANEAL EPİN HASTALARINDA FİZİKSEL AKTİVİTE DÜZEYİNİN AYAK AĞRISI VE FONKSİYONEL PERFORMANS ÜZERİNDEKİ ETKİSİ(2020) Vergili, Özge; Oktaş, Birhan; Aktaş, Fatma Cansu; Arıkan, Halime; Deveci, Hülya; Arslan, Fatma Cansu AktaşAMAÇ: Kalkaneal epin, hastalara ciddi anlamda rahatsızlık vererek günlük yaşam aktivitelerini kısıtlar. Çalışmamızın amacı bu bireylerde fiziksel aktivite düzeyinin ağrı ve fonksiyonellik yanıtları üzerindeki etkisini araştırmaktı. GEREÇ VE YÖNTEM: Çalışma kalkaneal epin tanısı konmuş 41 birey ile yapıldı. Bireylerin yaş, cinsiyet, boy, kilo, beden kütle indeksi (BKİ) ve topuk ağrılarına ilişkin niteliksel ve niceliksel özellikleri sorgulandı. Bireylerin fiziksel aktivite düzeylerini değerlendirmek için Uluslararası Fiziksel Aktivite Anketi (UFAA) kullanıldı. Ayak ağrısını değerlendirmek için algometre, fonksiyonel performanslarını belirlemek için 6 dakika yürüme testi ve topuk yükseltme testi kullanıldı. BULGULAR: Bireylerin 8’i (%19,5) düşük düzeyde aktivite, 26’sı (%63,4) orta düzeyde aktivite ve 7’si (%17,1) yüksek düzeyde aktiviteye sahipti. Fiziksel aktivite düzeylerine göre sınıflandırılan bireylerde ayak ağrısı ve fonksiyonel performans parametreleri açısından anlamlı bir fark görülmedi. SONUÇ: Farklı fiziksel aktivite düzeyine sahip gruplar arasında ağrı ve fonksiyonel performans açısından farklılık çıkmamış olsa da çok yüksek düzeyde fiziksel aktivitenin topuk ağrısı / plantar fasit / kalkaneal epin gelişimi için önemli bir risk faktörü olduğu, bunun özellikle de yüksek BKİ’ye sahip kişilerde daha sık görüldüğü bilinmektedir. Aktif bir yaşamın ve egzersiz alışkanlığının sistemik endokrin yanıtlar, kas iskelet sistemi ve vücut kompozisyonu üzerindeki olumlu etkileri ile söz konusu şikayetlerin görülme sıklığını azaltabileceği unutulmamalıdır.Research Project Yumuşak Kıkırdak Doku Onarımı/rekonstruksiyonu için Gözenekli/biyoaktif Slikon İmplantların/protezlerin Üretimi(2011) Türkoğlu, Hilal Şaşmazel-Article Citation - Scopus: 4Frequency of Fibromyalgianess in Patients With Rheumatoid Arthritis and Ankylosing Spondylitis: a Multicenter Study of Turkish League Against Rheumatism (tlar) Network(Turkish League Against Rheumatism (TLAR), 2024) Kozanoğlu, Erkan; Kelle, Bayram; Alaylı, Gamze; Kuru, Ömer; Fırat, Sibel Çubukçu; Demir, Ali Nail; Akıncı, Ayşen; Ünal, İlker; Çubukçu Fırat, Sibel; Ayhan, Fikriye Figen; Kaya, TaciserObjectives: This study aimed to evaluate the frequency of fibromyalgianess, fibromyalgia syndrome (FS), and widespread pain in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and their relationship with clinical and demographic parameters. Patients and methods: This cross-sectional multicenter trial was performed in 14 centers across Türkiye between June 2018 and November 2019. Out of 685 patients recruited from the accessible population, 661 patients (342 RA, 319 AS; 264 males, 397 females; mean age: 48.1±12.9 years; range, 17 to 88 years) met the selection criteria. In these cohorts, those who did not meet the criteria for FS and had widespread pain (widespread pain index ≥7) were evaluated as a separate group. Clinical status and demographic parameters of patients in both cohorts were evaluated as well as the evaluations of RA and AS patients with widespread pain (widespread pain index ≥7) and RA and AS patients with FS groups. In addition, correlations between polysymptomatic distress scale (PSD) scores and Visual Analog Scale (VAS), Simplified Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI), and Disease Activity Score using 28 joint counts for RA patients and VAS, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and Ankylosing Spondylitis Disease Activity Score (ASDAS) for AS patients were analyzed. Results: Frequencies of patients with FS and patients who had PSD scores ≥12 were 34.1% and 44.4% in all RA patients, respectively. Moreover, FS and PSD scores ≥12 were found in 29.2% and 36.9% of all AS patients, respectively. PSD scores of RA patients with FS were higher than all RA patients and RA patients with widespread pain. SDAI and CDAI scores of RA patients with FS were higher than all RA patients and RA patients with widespread pain. Similarly, PSD scores of AS patients with FS were higher than all AS patients and AS patients with widespread pain. ASDAS-erythrocyte sedimentation rate and BASDAI scores of AS patients with FS were found higher than all AS patients and AS patients with widespread pain. Conclusion: Disease activity scores, including pain in RA and AS, were higher in the presence of FS or fibromyalgianess. It may be related to clinical parameters, but cohort studies with long-term follow-up are needed to reveal causality. Additionally, to avoid overtreatment, coexistence of fibromyalgianess should be kept in mind in patients who have inflammatory diseases such as RA and AS, particularly with intractable widespread pain.
