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Article Protective Role of Bromelain’s Antioxidant and Anti-Inflammatory Effects in Experimental Lower Limb Ischemia-Reperfusion Injury(Nature Portfolio, 2025) Sezen, Saban Cem; Demirtas, Huseyin; Yildirim, Alperen Kutay; Ozer, Abdullah; Dursun, Ali Dogan; Kucuk, Aysegul; Arslan, Mustafa; Ozalp, Veli Cengiz; Kucuk, Işın GunesIschemia-reperfusion (IR) injury is a multifaceted pathological process characterized by excessive oxidative stress and inflammatory responses upon restoration of blood flow. Bromelain, a proteolytic enzyme complex derived from pineapple, exhibits robust antioxidant and anti-inflammatory activities. This study aimed to evaluate the protective effects and underlying mechanisms of bromelain on oxidative stress and inflammation in an experimental rat model of lower limb ischemia-reperfusion injury. Twenty-four male Wistar Albino rats were randomly allocated into four groups: Sham-operated control (SHAM), Bromelain-only (BR), Ischemia-Reperfusion (IR), and Ischemia-Reperfusion with Bromelain treatment (IR + BR). Bromelain (40 mg/kg) was administered intraperitoneally before ischemia induction. The IR model involved 45 min of infrarenal abdominal aorta occlusion followed by 120 min of reperfusion. Oxidative biomarkers (total antioxidant status [TAS], total oxidant status [TOS], oxidative stress index [OSI]) and histopathological parameters (muscle atrophy, degeneration, leukocyte infiltration, internalization of nuclei, fragmentation, and hyalinization) were analyzed. Significant increases in muscle degeneration, leukocyte infiltration, nuclear internalization, fragmentation, and elevated oxidative stress biomarkers (increased TOS and OSI, decreased TAS) were observed in the IR group compared to controls. Bromelain treatment (IR + BR) significantly ameliorated these effects, reducing muscle tissue damage, inflammation, and oxidative imbalance compared to the untreated IR group. Bromelain effectively mitigates lower limb ischemia-reperfusion injury by reducing oxidative stress, restoring antioxidant capacity, and suppressing inflammatory responses. These protective effects suggest that bromelain holds potential as a therapeutic agent for managing oxidative and inflammatory damages associated with IR conditions, warranting further clinical investigation.Article Citation - WoS: 5Citation - Scopus: 3Investigation of Λ (1405)as a molecular pentaquark state(Springer, 2024) Azizi, K.; Sarac, Y.; Sundu, H.Lambda ( 1405 ) is one of the interesting particles with its unclear structure and distinct properties. It has a light mass compared to its non-strange counterpart, despite the strange quark it carries. This situation puts the investigation of this resonance among the hot topics in hadron physics and collects attention to clarify its properties. In this study, we focus on the calculation of the mass and residue of the Lambda ( 1405 ) resonance within the framework of QCD sum rules. We assign a structure in the form of a molecular pentaquark composed from admixture of K - meson-neutron. Using an interpolating current in this form, the masses and the current coupling constant are attained as m = 1406 +/- 128 MeV and lambda = ( 3.35 +/- 0.35 ) x 10( - 5) GeV 6 for q and m = 1402 +/- 141 MeV and lambda = ( 4.08 +/- 1.08 ) x 10( - 5) GeV 6 for I Lorentz structures entering the calculations, respectively. The obtained mass values agree well with the experimental data supporting the plausibility of the considered structure.Article Citation - WoS: 10Citation - Scopus: 11Analysis of Space Efficiency in High-Rise Timber Residential Towers(Mdpi, 2024) Ilgin, Hueseyin Emre; Aslantamer, Ozlem NurHigh-rise timber residential towers (>= eight-stories) represent a burgeoning and auspicious sector, predominantly due to their capability to provide significant ecological and financial advantages throughout their lifecycle. Like numerous other building types, spatial optimization in high-rise timber residential structures stands as a pivotal design factor essential for project viability. Presently, there exists no comprehensive investigation on space efficiency in such towers. This study analyzed data from 51 case studies to enhance understanding of the design considerations influencing space efficiency in high-rise timber residential towers. Key findings included (1) the average space efficiency within the examined cases was recorded at 83%, exhibiting variances ranging from 70% to 93% across different cases, (2) the average percentage of core area to gross floor area (GFA) was calculated at 10%, demonstrating fluctuations within the range of 4% to 21% across diverse scenarios, and (3) no notable distinction was observed in the effect of various core planning strategies on spatial efficiency when properly designed, and similar conclusions were drawn regarding building forms and structural materials. This research will aid in formulating design guidelines tailored for various stakeholders such as architectural designers involved in high-rise residential timber building developments.Article Citation - WoS: 1Citation - Scopus: 1Detection of Sexually Transmitted Infection Agents in Pregnant Women Using Multiplex Polymerase Chain Reaction Method(BMC, 2025) Bakir, Ayfer; Cendek, Busra Demir; Usluca, Selma; Aral, Murat; Korkut, Gizem; Morkoc, Mehmet; Keskin, Huseyin LeventBackgroundSexually transmitted infections (STIs) are a significant public health concern that can lead to serious outcomes such as infertility, pregnancy complications, and neonatal infections. This study aimed to evaluate the prevalence of STI and their associated risk factors in symptomatic and asymptomatic pregnant women.MethodsBetween July and October 2024, a total of 300 pregnant women in their third trimester, including 113 symptomatic and 187 asymptomatic individuals aged 18 to 45 years, who sought antenatal care at the Gynecology and Obstetrics Clinic of Ankara Etlik City Hospital, were included in the study. The detection of STIs agents in vaginal swab samples was performed using multiplex polymerase chain reaction in the Molecular Diagnosis Laboratory of the Department of Microbiology.ResultsThe overall prevalence of STIs was 34.3% (103/300), with single and multiple infections accounting for 28.3% and 6.0% of cases, respectively. The most frequently detected pathogens were Ureaplasma parvum/urealiticum (29.0%), Mycoplasma hominis (4.6%), and Chlamydia trachomatis (2.3%). Co-infections were commonly observed between Ureaplasma parvum/urealiticum and Mycoplasma hominis. No significant difference in STI prevalence was observed between the symptomatic (35.4%) and asymptomatic (33.7%) groups. Co-infection with non-STI bacterial agents, such as Gardnerella vaginalis and Streptococcus agalactiae, increased the risk of STIs by 1.96 times (p = 0.006).ConclusionsThis study revealed that STIs occur at similar rates among symptomatic and asymptomatic pregnant women. This finding highlights the critical importance of detecting asymptomatic cases to prevent the spread of silent infections and to safeguard maternal and neonatal health. Ureaplasma parvum/urealiticum were identified as the most common pathogens. Given that co-infections with non-STI bacterial agents significantly increase the risk of STIs, multiplex PCR-based multicenter and prospective studies are essential to refine screening strategies for pregnant women.Article Citation - WoS: 7Citation - Scopus: 10Space Efficiency in North American Skyscrapers(Mdpi, 2024) Ilgin, Huseyin Emre; Aslantamer, Ozlem NurSpace efficiency in North American skyscrapers is crucial due to financial, societal, and ecological reasons. High land prices in major cities require maximizing every square foot for financial viability. Skyscrapers must accommodate growing populations within limited spaces, reducing urban sprawl and its associated issues. Efficient designs also support environmental sustainability and enhance city aesthetics, while optimizing infrastructure and services. However, no comprehensive study has examined the key architectural and structural features impacting the space efficiency of these towers in North America. This paper fills this gap by analyzing data from 31 case study skyscrapers. Findings indicated that (1) central core was frequently employed in the organization of service core; (2) most common forms were setback, prismatic, and tapered configurations; (3) outriggered frame and shear walled frame systems were mostly used; (4) concrete was the material in most cases; and (5) average space efficiency was 76%, and the percentage of core area to gross floor area (GFA) averaged 21%, from the lowest of 62% and 13% to the highest of 84% and 31%. It is expected that this paper will aid architectural and structural designers, and builders involved in shaping skyscrapers in North America.Article Citation - WoS: 4Citation - Scopus: 4A Site Survey of Damaged Rc Buildings in Izmir After the Aegean Sea Earthquake on October 30, 2020(Croatian Soc Civil Engineers-hsgi, 2023) Mertol, Halit Cenan; Tunc, Gokhan; Akis, TolgaAn earthquake with a magnitude of Mw = 6.6 and a depth of approximately 16.5 km occurred on 30 October 2020 off the cost of Samos, a Greek island 35 km southwest of Seferihisar, a town in Izmir. The earthquake caused several collapses and severe structural damage in approximately 6,000 buildings, specifically in the Bayrakli District in Izmir Bay. This paper presents the observations and findings of a technical team that visited the earthquake -affected areas immediately after the earthquake. Eleven partially or fully collapsed and several severely damaged reinforced concrete buildings were investigated. Based on the site investigations, we observed that almost all of the collapsed or severely damaged reinforced concrete buildings in the region were built between 1975 and 2000. Site observations also confirmed that the construction of these collapsed or damaged buildings did not conform to the requirements outlined in the Turkish Earthquake Codes used at the time. The failures and severe damage to buildings in earthquake-affected areas are primarily related to inadequate reinforcement configuration, poor material quality, the absence of geotechnical studies, and framing problems related to their lateral load-carrying systems. Therefore, it is recommended that all the buildings located in and around Izmir Bay, particularly those built between 1975 and 2000, be structurally evaluated to prevent any further loss of life and property during future earthquakes.Article Citation - WoS: 5Citation - Scopus: 7High-Rise Timber Offices: Main Architectural and Structural Design Parameters(Mdpi, 2024) Ilgin, Hueseyin Emre; Aslantamer, Ozlem NurHigh-rise office structures constructed using timber material (with a minimum of eight stories) signify a burgeoning and favorable sector, mainly owing to their ability to offer substantial environmental and economic advantages across their lifespan. However, it is crucial to recognize that the current corpus of scholarly literature lacks a thorough investigation into vital aspects concerning the architectural and structural planning of these sustainable structures. In an effort to fill this gap and augment the understanding of advancing international tendencies, this paper delved into data originating from 27 high-rise offices on a worldwide scale. The primary findings were: (i) Central core arrangements were the most popular, accounting for 67%, followed by peripheral types at 22%. (ii) Prismatic designs were the most frequently used at 85%, with free forms making up 11%. (iii) Material combinations involving timber and concrete were widely prevalent, making up 70% of composite constructions, which were 74% of the sample group, with pure timber constructions at 26%. (iv) Structural systems predominantly utilized shear walled frame systems, comprising 85% of the total. This article serves as a valuable resource for architectural designers, offering guidance on planning and executing future sustainable developments in the domain of high-rise timber office.Article Citation - WoS: 2Citation - Scopus: 3Space Efficiency in European High-Rise Timber Buildings(Mdpi, 2024) Ilgin, Huseyin Emre; Aslantamer, Ozlem NurAs towering wooden edifices (>= 8 stories) become a rapidly expanding and promising field, they provide substantial environmental and economic advantages throughout their entire lifespans, leading to their increasing popularity, especially in the European context. Similar to various other construction forms, spatial efficiency is a vital design criterion in timber buildings to guarantee the viability of a project. Currently, there is no thorough study on spatial efficiency in these towers in Europe, which is home to the majority of the world's timber towers. This paper examined data from 56 cases to improve comprehension of the planning factors affecting space efficiency in these buildings. The main findings showed that the average space efficiency across the analyzed examples was documented at 82%, with deviations spanning from 70% to 90%, the average core area to gross floor area (GFA) ratio was determined to be 11%, ranging from 4% to 21%, and no substantial difference was noted in the impact of core arrangements on space efficiency, and parallel findings were observed for forms and construction materials. This article aspires to provide architectural designers with essential perspectives, assisting and directing them in the conception and realization of upcoming ventures both across Europe and internationally in this domain.Article Citation - WoS: 4Citation - Scopus: 7Real-Time Learning and Monitoring System in Fighting Against Sars-Cov in a Private Indoor Environment(Mdpi, 2022) Erisen, SerdarThe SARS-CoV-2 virus has posed formidable challenges that must be tackled through scientific and technological investigations on each environmental scale. This research aims to learn and report about the current state of user activities, in real-time, in a specially designed private indoor environment with sensors in infection transmission control of SARS-CoV-2. Thus, a real-time learning system that evolves and updates with each incoming piece of data from the environment is developed to predict user activities categorized for remote monitoring. Accordingly, various experiments are conducted in the private indoor space. Multiple sensors, with their inputs, are analyzed through the experiments. The experiment environment, installed with microgrids and Internet of Things (IoT) devices, has provided correlating data of various sensors from that special care context during the pandemic. The data is applied to classify user activities and develop a real-time learning and monitoring system to predict the IoT data. The microgrids were operated with the real-time learning system developed by comprehensive experiments on classification learning, regression learning, Error-Correcting Output Codes (ECOC), and deep learning models. With the help of machine learning experiments, data optimization, and the multilayered-tandem organization of the developed neural networks, the efficiency of this real-time monitoring system increases in learning the activity of users and predicting their actions, which are reported as feedback on the monitoring interfaces. The developed learning system predicts the real-time IoT data, accurately, in less than 5 milliseconds and generates big data that can be deployed for different usages in larger-scale facilities, networks, and e-health services.Article Türkiye’deki Sürdürülebilir Mavi Ekonomi ve Deniz Yönetişimi İmkanlarının Değerlendirilmesi: Bakanlıklar Düzeyinde Bir İnceleme(Karadeniz Doğa ve Çevre Derneği, 2024) Karlı, AygünKamu politikası yaklaşımı açısından değerlendirildiğinde denizel çevre politikaları, son on beş senedir önemini arttıran bir konu halini almıştır. Devletler, uluslararası örgütler, sivil toplum kuruluşları ve üniversitelerin ortak bir çözüm arayışı içerisinde oldukları temel konu ise okyanus ve denizlerdeki kirliliğin azaltılması ve okyanus ile denizlerden sürdürülebilir bir şekilde nasıl yararlanılacağıdır. Mavi büyüme ve mavi ekonomi kavramlarının 2000’lerin ortalarından itibaren öneminin artmasıyla birlikte okyanus ve denizlerden yararlanılma süreçlerine kamu politikaları açısından müdahale edilme gerekliliği de önemli bir süreç olarak ortaya çıkmıştır. Bu doğrultuda, kamu politikalarının yapıcısı ve uygulayıcısı olan kamu otoritelerinin balıkçılık, su ürünleri yetiştiriciliği, gemi yapımı/sökümü/geri dönüşümü, liman yönetimi, kıyı turizmi, denizel biyoçeşitliliğin korunması, iklim değişikliğinin etkileri, derin deniz maden araştırmaları ve denizel yenilenebilir enerji gibi pek çok konuyu içerisinde barındıran deniz politikalarını düzenleme, uygulama ve yönetme süreçleri de karmaşık bir yapıya neden olabilmektedir. Bu karmaşık yapının anlaşılabilmesi için, devletlerin ilgili yasal düzenlemeleri sonucunda ortaya çıkan sürdürülebilir mavi ekonomi ve deniz yönetişimi konularının araştırılması ve bu konu başlıkları çerçevesinde devletin ilgili birimlerinin yetki süreçlerinin incelenmesi gerekmektedir. Bu süreçlerin incelenmesi, bu çalışmada, çevre politikası entegrasyonu kavramı çerçevesinde değerlendirilmiş ve Türkiye özelinde, bakanlıkların sürdürülebilir mavi ekonomi ve deniz yönetişimi konularındaki entegrasyonu incelenmiştir. Bu entegrasyonun incelenmesinin ön koşulu ise Türkiye’deki bakanlıkların sürdürülebilir mavi ekonomi ve deniz yönetişimi konusundaki görev alanlarının belirlenmesi ve çevre politikası entegrasyonu konusundaki kapasitelerinin ölçülmesidir. Son olarak, çevre politikası entegrasyonu çerçevesinde değerlendirilmiş olan Türkiye’nin sürdürülebilir mavi ekonomi ve deniz yönetişimi imkanları, Türkiye’deki denizel çevre politikalarının görev ve yetki karmaşası yaratıp yaratmadığı açısından da tartışılmıştır. Değerlendirmenin temel ölçütü olarak 1 Numaralı Cumhurbaşkanlığı Teşkilatı Hakkında Cumhurbaşkanlığı Kararnamesi ele alınmış ve bakanlıkların denizel çevre politikalarıyla ilişkili olarak sürdürülebilir mavi ekonomi ve deniz yönetişimi konularındaki görev ve yetki hususları ilgili kategorilere ayrılarak incelenmiştir.