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Access Right: info:eu-repo/semantics/openAccessAuthor: Basar, Ahmet Ozan

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    Article
    Citation - WoS: 4
    Citation - Scopus: 5
    In Vitro Evaluation of Tooth-Colored Yttria Stabilized Zirconia Ceramics
    (Taylor & Francis Ltd, 2021) Akarsu, Melis Kaplan; Basar, Ahmet Ozan; Sasmazel, Hilal Turkoglu; Park, Jongee; Ozturk, Abdullah
    Effects of MoCl3 and NiCl2, originally incorporated as coloring agent, on the cellular response of 3 mol% yttria stabilized zirconia (3Y-TZP) ceramics was investigated. MoCl3 and NiCl2-MoCl3 incorporated, tooth-colored 3Y-TZP ceramics were produced through cold isostatic pressing at 100 MPa followed by pressureless sintering at 1450 degrees C for 2 h. Aging was performed on the sintered ceramics using distilled water in a reactor at 134 degrees C at 2.3 bar pressure for 2 h. The phases developed during different stages of processing were identified by X-ray diffraction (XRD) analysis. In vitro cell culture studies were carried out using L929 fibroblast cell line. The cell viability and proliferation studies revealed that none of the specimens showed cytotoxicity with respect to coloring. Confocal laser scanning microscope (CLSM) analyses suggested that all of the specimens exhibited good in vitro cytocompatibility. Enhancement in cell attachment, adhesion, and proliferation was observed in all specimens via scanning electron microscope (SEM) analysis. Although the coloring process did not improve the proliferation performance of the aged specimens, the incorporation of transition metals enhanced the in vitro performance of 3Y-TZP ceramics.
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    Article
    Citation - WoS: 35
    Citation - Scopus: 49
    Encapsulation of Β-Carotene by Emulsion Electrospraying Using Deep Eutectic Solvents
    (Mdpi, 2020) Ozan Basar, Ahmet; Prieto, Cristina; Durand, Erwann; Villeneuve, Pierre; Sasmazel, Hilal Turkoglu; Lagaron, Jose; Basar, Ahmet Ozan
    The encapsulation beta-carotene in whey protein concentrate (WPC) capsules through the emulsion electrospraying technique was studied, using deep eutectic solvents (DES) as solvents. These novel solvents are characterized by negligible volatility, a liquid state far below 0 degrees C, a broad range of polarity, high solubilization power strength for a wide range of compounds, especially poorly water-soluble compounds, high extraction ability, and high stabilization ability for some natural products. Four DES formulations were used, based on mixtures of choline chloride with water, propanediol, glucose, glycerol, or butanediol. beta-Carotene was successfully encapsulated in a solubilized form within WPC capsules; as a DES formulation with choline chloride and butanediol, the formulation produced capsules with the highest carotenoid loading capacity. SEM micrographs demonstrated that round and smooth capsules with sizes around 2 mu m were obtained. ATR-FTIR results showed the presence of DES in the WPC capsules, which indirectly anticipated the presence of beta-carotene in the WPC capsules. Stability against photo-oxidation studies confirmed the expected presence of the bioactive and revealed that solubilized beta-carotene loaded WPC capsules presented excellent photo-oxidation stability compared with free beta-carotene. The capsules developed here clearly show the significant potential of the combination of DES and electrospraying for the encapsulation and stabilization of highly insoluble bioactive compounds.