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Conference Object Domestic Cooking, Bmi, and Factors Determining Women's Involvement - Tdhs-2013 Study Findings(Karger, 2020) Kalyoncu, Z. Begum; Merdol, Turkan; Yildirim, Gonca; Cetiner, Ozlem; Gunesliol, Bartu Eren; Dag, Ayhan; Adali, Tugba[No Abstract Available]Article Citation - WoS: 1Citation - Scopus: 1Dietary Total Antioxidant Capacity and Oxidative Stress in Patients With Type-2 Diabetes(Mattioli 1885, 2021) Cetiner, Ozlem; Sendur, Suleyman Nahit; Yalcin, Tuba; Bayraktar, Miyase; Rakicioglu, NeslisahBackground: Reactive oxygen species can disrupt normal cellular functions by damaging DNA, protein, and lipid structures of the cell. Some antioxidant molecules may protect the body against reactive oxygen species. We aimed to investigate the relationship between the dietary intake of antioxidants and oxidative DNA damage in diabetic patients. Material and Methods: A total of 85 individuals were included in the study, of which 30 were newly diagnosed with type-2 diabetes, 30 were formerly diagnosed with type-2 diabetes, and 25 were healthy individuals. Twenty-four-hour dietary recalls were recorded for 3 consecutive days. Dietary total antioxidant capacity and dietary oxidative balance scores were calculated according to these records. Spot urine samples were collected and analyzed for 8-hydroxy-2' deoxyguanosine/creatinine. Results: Dietary total antioxidant capacity, estimated via different methods, was higher in the controls than that in patients with type-2 diabetes (p<0.05). The urinary 8-hydroxy-2'-deoxyguanosine/creatinine ratio, a reliable predictor of oxidative DNA damage, was also higher in non-diabetic patients (p<0.05). The urinary 8-hydroxy-2'-deoxyguanosine/creatinine ratio was not related to dietary antioxidant intake (p>0.05). Conclusion: Urinary 8-hydroxy-2'-deoxyguanosine/creatinine concentration may not always reflect the current oxidative status of the body.Article Citation - WoS: 1Citation - Scopus: 1Long-Term Intermittent Caloric Restriction Remodels the Gut Microbiota in Mice Genetically Prone To Breast Cancer(Elsevier Science inc, 2024) Keles, Nazim Arda; Dogan, Soner; Dogan, Aysenur; Sudagidan, Mert; Balci, Tugce Nur; Cetiner, Ozlem; Tuna, Bilge GuvencObjectives: Gut microbiota dysbiosis is among the risk factors for breast cancer development, together with genetic background and dietary habits. However, caloric restriction has been shown to remodel the gut microbiota and slow tumor growth. Here, we investigated whether the gut microbiota mediates the preventive effects of long-term chronic or intermittent caloric restriction on breast cancer predisposition. Methods: 10-week-old transgenic breast cancer-prone mice were randomly assigned to dietary groups (ad libitum, chronic caloric restriction, and intermittent caloric restriction groups) and fed up to week 81. Stool samples were collected at weeks 10 (baseline), 17 (young), 49 (adult), and 81 (old). 16S rRNA gene sequencing was performed to identify the gut microbiota profile of the different groups. In order to investigate the breast cancer gut microbiota profile within genetically predisposed individuals regardless of diet, mammary tumor-bearing mice and mammary tumor-free but genetically prone mice were selected from the ad libitum group (n = 6). Results: Intermittent caloric restriction increased the microbial diversity of adult mice and modified age- related compositional changes. A total of 13 genera were differentially abundant over time. Pathogenic Mycoplasma was enriched in the re-feeding period of the old intermittent caloric restriction group compared with baseline. Furthermore, mammary tumor-free mice showed shared gut microbiota characteristics with mammary tumor-bearing mice, suggesting an early link between genetic predisposition, gut microbiota, and breast cancer development. Conclusions: Our study revealed the role of gut microbes in the preventive effects of caloric restriction against breast cancer development, implying the significance of diet and microbiome interplay. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Article Citation - WoS: 33Social Jetlag Is Associated With the Frequency of Consumption of Sugar-Sweetened Beverages and a High Bmi Percentile in Adolescents: Results of the Cross-Sectional Family Life, Activity, Sun, Health, and Eating (flashe) Study(Elsevier Science inc, 2021) Cetiner, Ozlem; Yildirim, Gonca; Kalyoncu, Zeynep BegumBackground Social jetlag (SJL) occurs in adolescents due to misalignment of the bio-logical and social clocks, so that most teens wake up earlier than their biological clocks on weekdays and delay bedtime and wake up time on weekends. This shift in sleep timing among adolescents is associated with an adverse endocrine and behavioral risk profile, in addition to increased food consumption and increased body mass index (BMI). Objective The aim of this study was to determine the association between SJL, and the frequency of consumption of multiple food and beverage groups and BMI percentile in adolescents. Design Publicly available data from the cross-sectional Family Life, Activity, Sun, Health, and Eating (FLASHE) study were analyzed. Participants Participants from the FLASHE study were recruited from all regions of the United States between April and October 2014. Among the 1,581 adolescents aged 12 through 17 years in the original study, 1,556 with complete sleep data were analyzed. Main outcome measures The difference between the frequency of dietary consump-tion according to the Dietary Screener Questionnaire and BMI percentile was assessed in adolescents grouped according to SJL, as follows: no SJL: less than 1-hour difference; mild SJL: 1-to 2-hour difference; and severe SJL: more than 2-hour difference. Statistical analyses performed Differences in the frequency of food consumption were analyzed using the Kruskal-Wallis test. Secondary outcomes were analyzed using logistic regression models. Results Daily consumption frequency of sugar-sweetened beverages and fruits and vegetables differed among the 3 groups. Likewise, the BMI percentile differed among the 3 groups and was highest in the severe SJL group. Those in the severe SJL group had a 1.84-fold higher probability of having overweight or obesity (95% CI 1.83 to 1.84) than those in the no SJL group. Conclusions Severe SJL is associated with a higher frequency of sugar-sweetened beverage consumption and higher odds of having overweight or obesity compared with no SJL in adolescents. J Acad Nutr Diet. 2021;121(9):1721-1731.
