Characteristics and Outcomes of Carbapenemase Harbouring Carbapenem-Resistant <i>klebsiella</I> Spp. Bloodstream Infections: a Multicentre Prospective Cohort Study in an Oxa-48 Endemic Setting
| dc.contributor.author | Isler, Burcu | |
| dc.contributor.author | Ozer, Berna | |
| dc.contributor.author | Cinar, Gule | |
| dc.contributor.author | Aslan, Abdullah Tarik | |
| dc.contributor.author | Vatansever, Cansel | |
| dc.contributor.author | Falconer, Caitlin | |
| dc.contributor.author | Ergonul, Onder | |
| dc.date.accessioned | 2024-07-05T15:18:33Z | |
| dc.date.available | 2024-07-05T15:18:33Z | |
| dc.date.issued | 2022 | |
| dc.description | Kapmaz, Mahir/0000-0002-4115-3914; DOGAN, OZLEM/0000-0002-6505-4582; Cinar, Gule/0000-0002-7635-8848; Vatansever, Cansel/0000-0003-3703-1882; Gönen, Mehmet/0000-0002-2483-075X; Chatfield, Mark D/0000-0002-0004-6274; Aydın, Mehtap/0000-0003-4044-9366; Tukenmez Tigen, Elif/0000-0003-2027-4116; Keske, Şiran/0000-0003-3823-4454; Ergonul, Onder/0000-0003-1935-9235; Kurt Azap, Özlem/0000-0002-3171-8926; can, fusun/0000-0001-9387-2526; balkan, ilker inanc/0000-0002-8977-5931; Azap, Alpay/0000-0001-5035-055X; Falconer, Caitlin/0000-0002-0476-7714 | en_US |
| dc.description.abstract | A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam. | en_US |
| dc.description.sponsorship | Pfizer Global Medical Grants [56644459] | en_US |
| dc.description.sponsorship | This work was supported by Pfizer Global Medical Grants (grant number 56644459). | en_US |
| dc.identifier.doi | 10.1007/s10096-022-04425-4 | |
| dc.identifier.issn | 0934-9723 | |
| dc.identifier.issn | 1435-4373 | |
| dc.identifier.scopus | 2-s2.0-85126797654 | |
| dc.identifier.uri | https://doi.org/10.1007/s10096-022-04425-4 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14411/1856 | |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartof | European Journal of Clinical Microbiology & Infectious Diseases | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | OXA-48 | en_US |
| dc.subject | OXA-232 | en_US |
| dc.subject | ST2096 | en_US |
| dc.subject | Klebsiella pneumoniae | en_US |
| dc.subject | Ceftazidime-avibactam | en_US |
| dc.title | Characteristics and Outcomes of Carbapenemase Harbouring Carbapenem-Resistant <i>klebsiella</I> Spp. Bloodstream Infections: a Multicentre Prospective Cohort Study in an Oxa-48 Endemic Setting | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Kapmaz, Mahir/0000-0002-4115-3914 | |
| gdc.author.id | DOGAN, OZLEM/0000-0002-6505-4582 | |
| gdc.author.id | Cinar, Gule/0000-0002-7635-8848 | |
| gdc.author.id | Vatansever, Cansel/0000-0003-3703-1882 | |
| gdc.author.id | Gönen, Mehmet/0000-0002-2483-075X | |
| gdc.author.id | Chatfield, Mark D/0000-0002-0004-6274 | |
| gdc.author.id | Falconer, Caitlin/0000-0002-0476-7714 | |
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| gdc.author.wosid | Kapmaz, Mahir/AAD-3774-2020 | |
| gdc.author.wosid | Aslan, Abdullah Tarık/AAP-8774-2021 | |
| gdc.author.wosid | DOGAN, OZLEM/M-4757-2017 | |
| gdc.author.wosid | Cinar, Gule/ABA-2413-2020 | |
| gdc.author.wosid | Vatansever, Cansel/KAM-1768-2024 | |
| gdc.author.wosid | Paterson, David L/A-9258-2010 | |
| gdc.author.wosid | Azap, Alpay/KMA-1874-2024 | |
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| gdc.description.department | Atılım University | en_US |
| gdc.description.departmenttemp | [Isler, Burcu; Falconer, Caitlin; Chatfield, Mark D.; Forde, Brian; Paterson, David L.] Univ Queensland, Ctr Clin Res, Brisbane, Qld, Australia; [Ozer, Berna; Vatansever, Cansel; Dogan, Ozlem; Can, Fusun] Koc Univ, Sch Med, Clin Microbiol, Istanbul, Turkey; [Cinar, Gule; Azap, Alpay] Ankara Univ, Infect Dis & Clin Microbiol, Sch Med, Ankara, Turkey; [Aslan, Abdullah Tarik; Akova, Murat] Hacettepe Univ, Infect Dis & Clin Microbiol, Sch Med, Ankara, Turkey; [Dolapci, Istar] Ankara Univ, Clin Microbiol, Sch Med, Ankara, Turkey; [Simsek, Funda] Univ Hlth Sci, Minist Hlth, Infect Dis & Clin Microbiol, Prof Dr Cemil Tascioglu City Hosp, Istanbul, Turkey; [Tulek, Necla] Atilim Univ, Fac Med, Infect Dis & Clin Microbiol, Ankara, Turkey; [Demirkaya, Hamiyet; Azap, Ozlem] Baskent Univ, Ankara Hosp, Infect Dis & Clin Microbiol, Ankara, Turkey; [Menekse, Sirin] Kosuyolu Kartal Heart Training & Res Hosp, Infect Dis, Istanbul, Turkey; [Akalin, Halis] Uluda Univ, Infect Dis & Clin Microbiol, Sch Med, Bursa, Turkey; [Balkan, Ilker Inanc; Saltoglu, Nese] Istanbul Univ Cerrahpasa, Sch Med, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Aydin, Mehtap] Univ Hlth Sci, Umraniye Training & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Tigen, Elif Tukenmez] Marmara Univ, Pendik Training & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Demir, Safiye Koculu] Demiroglu Bilim Univ, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Kapmaz, Mahir] Koc Univ Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey; [Arabaci, Cigdem] Univ Hlth Sci, Minist Hlth, Clin Microbiol, Prof Dr Cemil Tascioglu City Hosp, Istanbul, Turkey; [Yagci, Serap] Ankara Numune Training & Res Hosp, Clin Microbiol, Ankara, Turkey; [Hazirolan, Gulsen] Hacettepe Univ, Clin Microbiol, Sch Med, Ankara, Turkey; [Bakir, Veli Oguzalp] Koc Univ, Grad Sch Sci & Engn, Istanbul, Turkey; [Gonen, Mehmet] Koc Univ, Coll Engn, Ind Engn, Istanbul, Turkey; [Keske, Siran; Gonen, Mehmet; Ergonul, Onder] Koc Univ, Sch Med, Infect Dis, TR-34450 Istanbul, Turkey; [Keske, Siran; Can, Fusun; Ergonul, Onder] Koc Univ, Is Bank Ctr Infect Dis KUISCID, Istanbul, Turkey | en_US |
| gdc.description.endpage | 847 | en_US |
| gdc.description.issue | 5 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.volume | 41 | en_US |
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| gdc.oaire.keywords | Mikrobiyoloji | |
| gdc.oaire.keywords | Immunology | |
| gdc.oaire.keywords | Life Sciences (LIFE) | |
| gdc.oaire.keywords | Microbial Sensitivity Tests | |
| gdc.oaire.keywords | NDM-1 | |
| gdc.oaire.keywords | IMMUNOLOGY | |
| gdc.oaire.keywords | beta-Lactamases | |
| gdc.oaire.keywords | Bacterial Proteins | |
| gdc.oaire.keywords | Sepsis | |
| gdc.oaire.keywords | Yaşam Bilimleri | |
| gdc.oaire.keywords | Health Sciences | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Prospective Studies | |
| gdc.oaire.keywords | OXA-48 | |
| gdc.oaire.keywords | OXA-232 | |
| gdc.oaire.keywords | İmmünoloji | |
| gdc.oaire.keywords | General Immunology and Microbiology | |
| gdc.oaire.keywords | Ceftazidime-avibactam | |
| gdc.oaire.keywords | COPRODUCTION | |
| gdc.oaire.keywords | Temel Bilimler | |
| gdc.oaire.keywords | Life Sciences | |
| gdc.oaire.keywords | INFECTIOUS DISEASES | |
| gdc.oaire.keywords | ENTEROBACTERALES | |
| gdc.oaire.keywords | Anti-Bacterial Agents | |
| gdc.oaire.keywords | Klebsiella Infections | |
| gdc.oaire.keywords | Klebsiella pneumoniae | |
| gdc.oaire.keywords | Infectious Diseases | |
| gdc.oaire.keywords | Carbapenems | |
| gdc.oaire.keywords | BULAŞICI HASTALIKLAR | |
| gdc.oaire.keywords | Yaşam Bilimleri (LIFE) | |
| gdc.oaire.keywords | ST2096 | |
| gdc.oaire.keywords | PNEUMONIAE | |
| gdc.oaire.keywords | SPREAD | |
| gdc.oaire.keywords | Natural Sciences | |
| gdc.oaire.keywords | Oxa-232 | |
| gdc.oaire.keywords | Spread | |
| gdc.oaire.keywords | Enterobacterales | |
| gdc.oaire.keywords | Pneumoniae | |
| gdc.oaire.keywords | Coproduction | |
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