Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant <i>Klebsiella</i> spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Springer
Abstract
A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.
Description
Kapmaz, Mahir/0000-0002-4115-3914; DOGAN, OZLEM/0000-0002-6505-4582; Cinar, Gule/0000-0002-7635-8848; Vatansever, Cansel/0000-0003-3703-1882; Gönen, Mehmet/0000-0002-2483-075X; Chatfield, Mark D/0000-0002-0004-6274; Aydın, Mehtap/0000-0003-4044-9366; Tukenmez Tigen, Elif/0000-0003-2027-4116; Keske, Şiran/0000-0003-3823-4454; Ergonul, Onder/0000-0003-1935-9235; Kurt Azap, Özlem/0000-0002-3171-8926; can, fusun/0000-0001-9387-2526; balkan, ilker inanc/0000-0002-8977-5931; Azap, Alpay/0000-0001-5035-055X; Falconer, Caitlin/0000-0002-0476-7714
Keywords
OXA-48, OXA-232, ST2096, Klebsiella pneumoniae, Ceftazidime-avibactam
Turkish CoHE Thesis Center URL
Citation
17
WoS Q
Q2
Scopus Q
Source
Volume
41
Issue
5
Start Page
841
End Page
847