Novel Poly(ε-caprolactone)/Gelatin Wound Dressings Prepared by Emulsion Electrospinning With Controlled Release Capacity of Ketoprofen Anti-Inflammatory Drug

dc.authorid Torres-Giner, Sergio/0000-0001-9071-9542
dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorid LAGARON, Jose/0000-0002-0502-359X
dc.authorscopusid 57195473881
dc.authorscopusid 57213726700
dc.authorscopusid 23487006700
dc.authorscopusid 35583571800
dc.authorscopusid 16680382000
dc.authorwosid Torres-Giner, Sergio/M-6422-2019
dc.contributor.author Basar, A. O.
dc.contributor.author Castro, S.
dc.contributor.author Torres-Giner, S.
dc.contributor.author Lagaron, J. M.
dc.contributor.author Sasmazel, H. Turkoglu
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T15:30:02Z
dc.date.available 2024-07-05T15:30:02Z
dc.date.issued 2017
dc.department Atılım University en_US
dc.department-temp [Basar, A. O.; Sasmazel, H. Turkoglu] Atilim Univ, Dept Met & Mat Engn, TR-06836 Ankara, Turkey; [Castro, S.; Torres-Giner, S.; Lagaron, J. M.] CSIC, Inst Agrochem & Food Technol IATA, Novel Mat & Nanotechnol Grp, Calle Catedrdt Agustin Escardino Benlloch 7, Paterna 46980, Spain en_US
dc.description Torres-Giner, Sergio/0000-0001-9071-9542; Turkoglu Sasmazel, Hilal/0000-0002-0254-4541; LAGARON, Jose/0000-0002-0502-359X en_US
dc.description.abstract In the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared by solution electrospinning of poly(e-caprolactone) (PCL) with Ketoprofen at a weight ratio of 5 wt%. This Ketoprofen-containing PCL solution was also used as the oil phase in a 7:3 (wt/wt) emulsion with gelatin dissolved in acidified water. The resultant stable oil-in-water (O/W) emulsion of PCL-in-gelatin, also containing Ketoprofen at 5 wt%, was electrospun to produce the binary mat. Cross-linking process was performed by means of glutaraldehyde vapor on the electrospun binary mat to prevent dissolution of the hydrophilic gelatin phase. The performed characterization indicated that Ketoprofen was successfully embedded in the single and binary electrospun mats, i.e. PCL and PCL/gelatin, and both mats showed high hydrophobicity but poor thermal resistance. In vitro release studies interestingly revealed that, in comparison to the single PCL electrospun mat, the binary PCL/gelatin mat significantly hindered Ketoprofen burst release and exhibited a sustained release capacity of the drug for up to 4 days. In addition, the electrospun Ketoprofen-loaded mats showed enhanced attachment and proliferation of L929 mouse fibroblast cells, presenting the binary mat the highest cell growth yield due to its improved porosity. The here-developed electrospun materials clearly show a great deal of potential as novel wound dressings with an outstanding controlled capacity to release drugs. en_US
dc.description.sponsorship Spanish Ministry of Economy and Competitiveness (MINECO) [AGL2015-63855-C2-1-R] en_US
dc.description.sponsorship The authors would like to acknowledge the Spanish Ministry of Economy and Competitiveness (MINECO) project AGL2015-63855-C2-1-R for financial support. The authors would also like to thank the European Cooperation Science & Technology (COST) Action MP1206 for their Short Term Scientific Mission (STSM) at IATA-CSIC, Valencia, and the Academic Writing Advisory Center (AWAC) of Atilim University for English language revision. en_US
dc.identifier.citationcount 113
dc.identifier.doi 10.1016/j.msec.2017.08.025
dc.identifier.endpage 468 en_US
dc.identifier.issn 0928-4931
dc.identifier.issn 1873-0191
dc.identifier.pmid 28887998
dc.identifier.scopus 2-s2.0-85028313476
dc.identifier.startpage 459 en_US
dc.identifier.uri https://doi.org/10.1016/j.msec.2017.08.025
dc.identifier.uri https://hdl.handle.net/20.500.14411/2988
dc.identifier.volume 81 en_US
dc.identifier.wos WOS:000410253800056
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 123
dc.subject Drug delivery en_US
dc.subject Emulsion electrospinning en_US
dc.subject Gelatin en_US
dc.subject Ketoprofen en_US
dc.subject PCL en_US
dc.subject Wound dressings en_US
dc.title Novel Poly(ε-caprolactone)/Gelatin Wound Dressings Prepared by Emulsion Electrospinning With Controlled Release Capacity of Ketoprofen Anti-Inflammatory Drug en_US
dc.type Article en_US
dc.wos.citedbyCount 117
dspace.entity.type Publication
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