Novel poly(ε-caprolactone)/gelatin wound dressings prepared by emulsion electrospinning with controlled release capacity of Ketoprofen anti-inflammatory drug

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Date

2017

Authors

Şaşmazel, Hilal Türkoğlu
Castro, S.
Torres-Giner, S.
Lagaron, J. M.
Sasmazel, H. Turkoglu

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Elsevier

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Metallurgical and Materials Engineering
(2004)
The main fields of operation for Metallurgical and Materials Engineering are production of engineering materials, defining and improving their features, as well as developing new materials to meet the expectations at every aspect of life and the users from these aspects. Founded in 2004 and graduated its 10th-semester alumni in 2018, our Department also obtained MÜDEK accreditation in the latter year. Offering the opportunity to hold an internationally valid diploma through the accreditation in question, our Department has highly qualified and experienced Academic Staff. Many of the courses offered at our Department are supported with various practice sessions, and internship studies in summer. This way, we help our students become better-equipped engineers for their future professional lives. With the Cooperative Education curriculum that entered into effect in 2019, students may volunteer to work at contracted companies for a period of six months with no extensions to their period of study.

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Abstract

In the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared by solution electrospinning of poly(e-caprolactone) (PCL) with Ketoprofen at a weight ratio of 5 wt%. This Ketoprofen-containing PCL solution was also used as the oil phase in a 7:3 (wt/wt) emulsion with gelatin dissolved in acidified water. The resultant stable oil-in-water (O/W) emulsion of PCL-in-gelatin, also containing Ketoprofen at 5 wt%, was electrospun to produce the binary mat. Cross-linking process was performed by means of glutaraldehyde vapor on the electrospun binary mat to prevent dissolution of the hydrophilic gelatin phase. The performed characterization indicated that Ketoprofen was successfully embedded in the single and binary electrospun mats, i.e. PCL and PCL/gelatin, and both mats showed high hydrophobicity but poor thermal resistance. In vitro release studies interestingly revealed that, in comparison to the single PCL electrospun mat, the binary PCL/gelatin mat significantly hindered Ketoprofen burst release and exhibited a sustained release capacity of the drug for up to 4 days. In addition, the electrospun Ketoprofen-loaded mats showed enhanced attachment and proliferation of L929 mouse fibroblast cells, presenting the binary mat the highest cell growth yield due to its improved porosity. The here-developed electrospun materials clearly show a great deal of potential as novel wound dressings with an outstanding controlled capacity to release drugs.

Description

Torres-Giner, Sergio/0000-0001-9071-9542; Turkoglu Sasmazel, Hilal/0000-0002-0254-4541; LAGARON, Jose/0000-0002-0502-359X

Keywords

Drug delivery, Emulsion electrospinning, Gelatin, Ketoprofen, PCL, Wound dressings

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113

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Volume

81

Issue

Start Page

459

End Page

468

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