Şaşmazel, Hilal Türkoğlu

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https://hdl.handle.net/20.500.14411/7080
Name Variants
S.,Hilal Turkoglu
Sasmazel, Hilal Tuerkoglu
Sasmazel, Hilal Turkoglu
H. T. Şaşmazel
Turkoglu Sasmazel H.
Sasmazel,H.T.
Şaşmazel,H.T.
Hilal Türkoğlu, Şaşmazel
H., Sasmazel
Şasmazel H.
S., Hilal Turkoglu
Ş.,Hilal Türkoğlu
Ş., Hilal Türkoğlu
Turkoğlu Şaşmazel H.
Hilal Turkoglu, Sasmazel
H.T.Sasmazel
H.T.Şaşmazel
Sasmazel H.
Sasmazel, H. T.
Türkoglu, H
Turkoglu, Hilal
Sasmazel, H. Turkoglu
Sasmazel, Hilal T.
H. T. Sasmazel
Şaşmazel, Hilal Türkoğlu
H.,Şaşmazel
Şaşmazel H.
Sasmazel, H. Tuerkodlu
Türkoǧlu Şaşmazel,H.
Şaşmazel, Hilal
Job Title
Profesor Doktor
Email Address
hilal.sasmazel@atilim.edu.tr
Main Affiliation
Metallurgical and Materials Engineering
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Website
ORCID ID
0000-0002-0254-4541
Scopus Author ID
16680382000
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
V-6900-2018

Sustainable Development Goals

14

LIFE BELOW WATER
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1

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2

ZERO HUNGER
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0

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11

SUSTAINABLE CITIES AND COMMUNITIES
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1

NO POVERTY
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12

RESPONSIBLE CONSUMPTION AND PRODUCTION
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7

AFFORDABLE AND CLEAN ENERGY
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5

GENDER EQUALITY
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3

GOOD HEALTH AND WELL-BEING
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27

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9

INDUSTRY, INNOVATION AND INFRASTRUCTURE
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13

CLIMATE ACTION
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6

CLEAN WATER AND SANITATION
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1

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10

REDUCED INEQUALITIES
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4

QUALITY EDUCATION
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15

LIFE ON LAND
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16

PEACE, JUSTICE AND STRONG INSTITUTIONS
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17

PARTNERSHIPS FOR THE GOALS
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8

DECENT WORK AND ECONOMIC GROWTH
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Documents

45

Citations

1387

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20

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Documents

50

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1276

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Scholarly Output

55

Articles

38

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9/0

Supervised MSc Theses

10

Supervised PhD Theses

0

WoS Citation Count

968

Scopus Citation Count

1022

WoS h-index

18

Scopus h-index

18

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0

WoS Citations per Publication

17.60

Scopus Citations per Publication

18.58

Open Access Source

11

Supervised Theses

10

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Journal of Nanoscience and Nanotechnology4
Bio-Medical Materials and Engineering3
International Journal of Biological Macromolecules2
Molecules2
Nanomaterials2
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Author: Gunduz, Oguzhan

Scholarly Output Search Results

Now showing 1 - 8 of 8
  • Thumbnail Image
    Article
    Citation - WoS: 6
    Citation - Scopus: 6
    A Drug-Eluting Nanofibrous Hyaluronic Acid-Keratin Mat for Diabetic Wound Dressing
    (Springernature, 2022) Su, Sena; Bedir, Tuba; Kalkandelen, Cevriye; Sasmazel, Hilal Turkoglu; Basar, Ahmet Ozan; Chen, Jing; Gunduz, Oguzhan
    Diabetes mellitus is a chronic metabolic disease associated with long-term multisystem complications, among which are non-healing diabetic foot ulcers (DFUs). Electrospinning is a sophisticated technique for the preparation of polymeric nanofibers impregnated with drugs for wound healing, burns, and diabetic ulcers. This study describes the fabrication and characterization of a novel drug-eluting dressing made of core-shell structured hyaluronic acid (HA)-keratin (KR)-polyethylene oxide (PEO) and polycaprolactone (PCL) nanofibers to treat diabetic wounds. The core-shell nanofibers produced by the emulsion electrospinning technique provide loading of metformin hydrochloride (MH), HA, and KR in the core of nanofibers, which in return improves the sustained long term release of the drug and prolongs the bioactivity. Morphological and chemical properties of the fibers were examined by SEM, FTIR, and XRD studies. It was observed that the fibers which contain HA and KR showed thin fiber structure, greater swelling capacity, fast degradation and increased cumulative drug release amount than neat emulsion fibers due to the hydrophilic nature of HA and KR. MH showed a sustained release from all fiber samples over 20 days and followed the first-order and Higuchi model kinetics and Fickian diffusion mechanism according to kinetic analysis results. In vitro cell culture studies showed that the developed mats exhibited enhanced biocompatibility performance with HA and KR incorporation. The results show that HA and KR-based emulsion electrospun fiber mats are potentially useful new nanofiber-based biomaterials in their use as drug carriers to treat diabetic wounds.
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    Article
    Citation - WoS: 37
    Citation - Scopus: 45
    Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering
    (Elsevier, 2021) Topsakal, Aysenur; Midha, Swati; Yuca, Esra; Tukay, Ari; Sasmazel, Hilal Turkoglu; Kalaskar, Deepak M.; Gunduz, Oguzhan
    Over the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.
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    Article
    Design and Fabrication of Dual-Layered PCL/PEG Theranostic Platforms Using 3D Melt Electrowriting for Targeted Delivery and Post-Treatment Monitoring
    (Springer, 2025) Ege, Zeynep Ruya; Enguven, Gozde; Ege, Hasan; Durukan, Barkan Kagan; Sasmazel, Hilal Turkoglu; Gunduz, Oguzhan
    Advanced pancreatic tumors remain highly resistant to treatment due to their dense stromal environment and poor vascularization, which limit drug penetration and efficacy. Even after surgical resection, the high recurrence rate frequently leads to poor prognosis and mortality. To address these challenges, we developed solvent-free three-dimensional (3D) melt electrowritten (MEW) theranostic microfiber patches composed of poly(epsilon-caprolactone) (PCL) and polyethylene glycol (PEG). The patches were designed as dual-layered, 10-layer structures, with gemcitabine (GEM) loaded in the bottom five layers for localized chemotherapy to suppress tumor recurrence, and indocyanine green (ICG) incorporated in the top five layers to enable fluorescence-based post-surgical monitoring. Following fabrication, the patches were characterized both materially and in vitro, with GEM loaded at 100, 250, or 500 mu g/ml. PEG incorporation improved patch flexibility, facilitating the implantation process. In vitro release analysis demonstrated an initial burst followed by sustained, pH-responsive GEM release (similar to 70% at pH 4.0 and similar to 30% at pH 7.4 for 500 mu g/mL GEM at 168 h), while ICG release reached similar to 25% (pH 7.4) and similar to 10% (pH 4.0). GEM-loaded patches significantly reduced Capan-1 cell viability in a dose- and time-dependent manner, achieving >= 50% reduction at 72 h with 500 mu g/mL. Importantly, ICG incorporation did not impair GEM cytotoxicity; confocal imaging confirmed ICG internalization in viable cells and showed a decline in ICG-positive cells with increasing GEM dose, supporting the potential for concurrent therapy and monitoring. Thus, the theranostic patches enable localized, pH-responsive GEM delivery with integrated ICG-based fluorescence imaging, achieving significant cytotoxicity against pancreatic cancer cells while providing a platform for post-surgical surveillance. This solvent-free, layer-addressable approach represents a promising strategy for personalized, locally implantable theranostic systems in pancreatic cancer treatment.
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    Article
    Citation - WoS: 7
    Citation - Scopus: 7
    Advanced 3d Printed Bone Scaffolds With Sodium Alginate/Tri-calcium Phosphate/Probiotic Bacterial Hydroxyapatite: Enhanced Mechanical and Biocompatible Properties for Bone Tissue Engineering
    (Elsevier Sci Ltd, 2024) Nouri, Sabereh; Emtiazi, Giti; Ulag, Songul; Gunduz, Oguzhan; Koyuncu, Ayse Ceren Calikoglu; Roghanian, Rasoul; Sasmazel, Hilal Turkoglu
    Introduction: The increasing prevalence of severe bone diseases, such as osteoporosis and critical bone defects, necessitates the development of more effective bone substitutes. This study addresses this need by investigating 3D-printed bone scaffolds composed of sodium alginate and tricalcium phosphate, enhanced with three distinct types of hydroxyapatite (HA): bovine-derived HA, commercially available HA, and HA enriched with probiotic bacteria. We aim to evaluate the performance of these scaffolds in terms of mechanical strength, biocompatibility, and their ability to support bone regeneration. Methods: The scaffolds were analyzed through various tests, including X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) to characterization. Scanning Electron Microscopy (SEM) was used to examine pore structure, while swelling and degradation tests evaluated the scaffold's stability. Compression testing determined mechanical strength, and in vitro cell culture assays assessed cell proliferation, osteogenic differentiation, and biomineralization. Results: SEM results indicated that 3D scaffolds with probiotic bacterial HA had the desired 472 mu m pore size. These scaffolds demonstrated a strain of 29.26 % and a compressive strength of 10 MPa, meeting the mechanical standards of human trabecular bone. Cell culture studies revealed enhanced cell proliferation by 50 %, osteogenic differentiation with 15.3 U/mg ALP activity, and 1.22-fold biomineralization, suggesting they are highly biocompatible and promote bone growth. Conclusion: Probiotic bacterial HA scaffolds exhibit ideal properties and biocompatibility, enhancing bone regeneration and serving as an ideal alternative to chemical types.
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    Article
    Citation - WoS: 24
    Citation - Scopus: 28
    Development of Amoxicillin-Loaded Electrospun Polyurethane/Chitosan Β-Tricalcium Phosphate Scaffold for Bone Tissue Regeneration
    (Ieee-inst Electrical Electronics Engineers inc, 2018) Topsakal, Aysenur; Uzun, Muhammet; Ugar, Gaye; Ozcan, Aslihan; Altun, Esra; Oktar, Faik Nuzhet; Gunduz, Oguzhan
    Biocompatible nanocomposite electrospun fibers containing Polyurethane/Chitosan/beta-Tri calcium phosphate with diverse concentrations were designed and produced through the electrospinning process for bone tissue engineering applications. After the production process, density measurement, viscosity, electrical conductivity, and tensile strength measurement tests were carried out as physical analyses of blended solutions. The chemical structural characterization was scrutinized using Fourier transform infrared spectrometer (FTIR), and scanning electron microscopy (SEM) was used to observe the morphological details of developed electrospun scaffolds. Cell viability, attachment, and proliferation were performed using a L929 fibroblast cell line. Based on the physical, SEM, FTIR analysis, and cell culture studies, preferable nanofiber composition was selected for further studies. Amoxicillin (AMX) was loaded to that selected nanofiber composition for examination of the drug release. In comparison with other studies on similar AMX controlled products, higher drug loading and encapsulation efficiencies were obtained. It has been clearly found that the developed nanofiber composites have potential for bone tissue engineering applications.
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    Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Physico-Chemical Characterization and in Vitro Biological Study of Manganese Doped Β-Tricalcium Phosphate-Based Ceramics for Bone Regeneration Applications
    (Springer, 2023) Arpak, Mehmet Can; Daglilar, Sibel; Kalkandelen, Cevriye; Balescu, Liliana-Marinela; Sasmazel, Hilal Turkoglu; Pasuk, Iuliana; Gunduz, Oguzhan
    This work evaluates the effects of manganese (Mn) doping on the morpho-structural features, mechanical performance, and in vitro biological response of beta-tricalcium phosphate (beta-TCP) derived bioceramics for bone tissue engineering applications. Five different Mn doping levels (i.e., 0.01%, 0.05%, 0.1%, 0.5%, and 1 wt.%) were investigated, with the beta-TCP-based bioceramics being sintered at four temperatures (i.e., 1000, 1100, 1200, and 1300 degrees C). A densification improvement was induced when using Mn in excess of 0.05 wt.%; the densification remained stationary in the sintering temperature range of 1200 - 1300 degrees C. The structural analyses evidenced that all samples sintered at 1000 and 1100 degrees C were composed of beta-TCP as major phase and hydroxyapatite (HA) as a minor constituent (similar to 4-6 wt.%). At the higher temperatures (1200 and 1300 degrees C), the formation of alpha-TCP was signalled at the expense of both beta-TCP and HA. The Mn doping was evidenced by lattice parameters changes. The evolution of the phase weights is linked to a complex inter-play between the capacity of the compounds to incorporate Mn and the thermal decomposition kinetics. The Mn doping induced a reduction in the mechanical performance (in terms of compressive strength, Vickers hardness and elastic modulus) of the beta-TCP-based ceramics. The metabolic activity and viability of osteoblastic cells (MC3T3-E1) for the ceramics were studied in both powder and compacted pellet form. Ceramics with Mn doping levels lower than 0.1 wt.% yielded a more favorable microenvironment for the osteoblast cells with respect to the undoped beta-TCP. No cytotoxic effects were recorded up to 21 days. The Mn-doped beta-TCPs showed a significant increase (p < 0.01) in alkaline phosphatase activity with respect to pure beta-TCP.
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    Article
    Citation - WoS: 86
    Citation - Scopus: 103
    Coaxial and Emulsion Electrospinning of Extracted Hyaluronic Acid and Keratin Based Nanofibers for Wound Healing Applications
    (Pergamon-elsevier Science Ltd, 2021) Su, Sena; Bedir, Tuba; Kalkandelen, Cevriye; Basar, Ahmet Ozan; Sasmazel, Hilal Turkoglu; Ustundag, Cem Bulent; Gunduz, Oguzhan
    Novel composites based on poly(epsilon-caprolactone)/polyethylene oxide loaded with hyaluronic acid(HA) and keratin(KR) were produced separately using emulsion and coaxial electrospinning methods. HA and KR were extracted from animal sources, characterized and loaded into coaxial fiber structures as bioactive agents, separately and together. Morphological, chemical, thermal, and mechanical characteristics of the fibers were investigated. According to the SEM results, diameters of smooth and beadless fibers fabricated via emulsion method were at nanoscale (sub-micron) while fibers of coaxial method were at micro scale. Benefitted electrospinning techniques demonstrated that hydrophobic and hydrophilic polymers can be advantageously combined. Core polymer specific FT-IR bands were not visible, their presence was proven with DSC analysis which confirms core-shell morphology of the fibers. In vitro studies exhibited spun mats did not have any cytotoxic effects and the HA and KR incorporated into the fiber structure synergistically increased cell viability and cell proliferation. This study demonstrated that the electrospun fibers containing HA and KR fabricated by both emulsion and coaxial methods can be efficient for wound healing applications.
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    Editorial
    Editorial: Biofabricated Materials for Tissue Engineering
    (Frontiers Media Sa, 2024) Sasmazel, Hilal Turkoglu; Gunduz, Oguzhan; Ramalingam, Murugan; Ulag, Songul
    [No Abstract Available]