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Citation - WoS: 5
Citation - Scopus: 5
Adaptation of Food Craving Inventory To Turkish Culture: a Validity and Reliability Study
(Bmc, 2022) Ozel, Irem Cagla; Yabanci Ayhan, Nurcan; Cetiner, Ozlem; Nutrition and Dietetics; 07. School of Health Sciences; 01. Atılım University
Plain English Summary This study was carried out to adapt the Food Craving Inventory to Turkish. The English version of inventory consists of 4 sub-factors that measure cravings for high-fat foods, carbohydrates/starches, sweets, and fast food fats, and creates a total score. The sample of the study consists of 621 individuals between the ages of 19-50 who voluntarily agree to participate in an online survey. This study revealed that FCI-TR is a valid instrument of specific food cravings in the Turkish adult population. Turkish version of the FCI also consist of 4 sub-factors. Women experienced more food craving for sweets than men. While the most craved food by women was chocolate, men scored significantly higher on bread than women. In addition, a relationship was found between food craving and body weight. Introduction The Food Craving Inventory is a 28-item self-report measure of specific food cravings. The inventory consists of 4 factors: high fats, sweets, carbohydrates/starches and fast-food fats. Purpose This study was carried out to evaluate the Turkish validity and reliability of the Food Craving Inventory, and to determine the psychometric properties and factor structure of the Turkish version. Methods The sample of the study consists of 621 individuals between the ages of 19-50 who voluntarily agree to participate in online survey. Validity and reliability analyses were performed for the Turkish version of Food Craving Inventory (FCI-TR). Confirmatory factor analysis was performed to evaluate the factor structure of the Turkish version of FCI. Results Confirmatory factor analysis yielded a four-factor structure as "sweets," "high-fats," "carbohydrates/starches" and "fast food fats". The Cronbach-alpha coefficient for the total score was 0.84; subfactors were calculated as 0.74 for "sweets", 0.64 for "high-fat foods", 0.65 for "carbohydrates/starches", and 0.66 for "fast-food fats". The scores of the FCI-TR factors and its total score significantly correlated with the sub-factors of Three Factor Eating Questionnaire (TFEQ). A significant correlation was found between body mass index (BMI) and high fats and fast-food fats factor score. Also total and factor scores of the FCI-TR were different between BMI groups. Conclusions This study demonstrates that the Turkish version of the FCI is a valid and reliable tool to measure food cravings in the Turkish population. FCI is also correlated with sub-factors of TFEQ.
Citation - WoS: 1
Citation - Scopus: 1
Adaptive Stimulus Design for Dynamic Recurrent Neural Network Models
(Frontiers Media Sa, 2019) Doruk, R. Ozgur; Zhang, Kechen; Electrical-Electronics Engineering; 06. School Of Engineering; 01. Atılım University
We present an adaptive stimulus design method for efficiently estimating the parameters of a dynamic recurrent network model with interacting excitatory and inhibitory neuronal populations. Although stimuli that are optimized for model parameter estimation should, in theory, have advantages over nonadaptive random stimuli, in practice it remains unclear in what way and to what extent an optimal design of time-varying stimuli may actually improve parameter estimation for this common type of recurrent network models. Here we specified the time course of each stimulus by a Fourier series whose amplitudes and phases were determined by maximizing a utility function based on the Fisher information matrix. To facilitate the optimization process, we have derived differential equations that govern the time evolution of the gradients of the utility function with respect to the stimulus parameters. The network parameters were estimated by maximum likelihood from the spike train data generated by an inhomogeneous Poisson process from the continuous network state. The adaptive design process was repeated in a closed loop, alternating between optimal stimulus design and parameter estimation from the updated stimulus-response data. Our results confirmed that, compared with random stimuli, optimally designed stimuli elicited responses with significantly better likelihood values for parameter estimation. Furthermore, all individual parameters, including the time constants and the connection weights, were recovered more accurately by the optimal design method. We also examined how the errors of different parameter estimates were correlated, and proposed heuristic formulas to account for the correlation patterns by an approximate parameter-confounding theory. Our results suggest that although adaptive optimal stimulus design incurs considerable computational cost even for the simplest excitatory-inhibitory recurrent network model, it may potentially help save time in experiments by reducing the number of stimuli needed for network parameter estimation.
Citation - WoS: 80
Citation - Scopus: 82
Amine Grafted Silica Supported Craupd Alloy Nanoparticles: Superb Heterogeneous Catalysts for the Room Temperature Dehydrogenation of Formic Acid
(Royal Soc Chemistry, 2015) Yurderi, Mehmet; Bulut, Ahmet; Caner, Nurdan; Celebi, Metin; Kaya, Murat; Zahmakiran, Mehmet; Chemical Engineering; 06. School Of Engineering; 01. Atılım University
Herein we show that a previously unappreciated combination of CrAuPd alloy nanoparticles and amine-grafted silica support facilitates the liberation of CO-free H-2 from dehydrogenation of formic acid with record activity in the absence of any additives at room temperature. Furthermore, their excellent catalytic stability makes them isolable and reusable heterogeneous catalysts in the formic acid dehydrogenation.
Citation - WoS: 9
Citation - Scopus: 11
Analysis of Publications on Health Information Management Using the Science Mapping Method: a Holistic Perspective
(Mdpi, 2024) Tengilimoglu, Dilaver; Orhan, Fatih; Tekin, Perihan Senel; Younis, Mustafa; Business; 05. School of Business; 01. Atılım University
Objective: In the age of digital transformation, there is a need for a sustainable information management vision in health. Understanding the accumulation of health information management (HIM) knowledge from the past to the present and building a new vision to meet this need reveals the importance of understanding the available scientific knowledge. With this research, it is aimed to examine the scientific documents of the last 40 years of HIM literature with a holistic approach using science mapping techniques and to guide future research. Methods: This study used a bibliometric analysis method for science mapping. Co-citation and co-occurrence document analyses were performed on 630 academic publications selected from the Web of Science core collection (WoSCC) database using the keyword "Health Information Management" and inclusion criteria. The analyses were performed using the R-based software Bibliometrix (Version 4.0; K-Synth Srl), Python (Version 3.12.1; The Python Software Foundation), and Microsoft (R) Excel (R) 2016. Results: Co-occurrence analyses revealed the themes of personal health records, clinical coding and data quality, and health information management. The HIM theme consisted of five subthemes: "electronic records", "medical informatics", "e-health and telemedicine", "health education and awareness", and "health information systems (HISs)". As a result of the co-citation analysis, the prominent themes were technology acceptance, standardized clinical coding, the success of HISs, types of electronic records, people with HIM, health informatics used by consumers, e-health, e-mobile health technologies, and countries' frameworks and standards for HISs. Conclusions: This comprehensive bibliometric study shows that structured information can be helpful in understanding research trends in HIM. This study identified critical issues in HIM, identified meaningful themes, and explained the topic from a holistic perspective for all health system actors and stakeholders who want to work in the field of HIM.
Citation - WoS: 7
Citation - Scopus: 9
Analysis of the Hall Effect in Tlgate₂ Single Crystals
(Iop Publishing Ltd, 2009) Qasrawi, A. F.; Gasanly, N. M.; Department of Electrical & Electronics Engineering; 15. Graduate School of Natural and Applied Sciences; 01. Atılım University
The electrical resistivity and Hall coefficient of p-type TlGaTe2 crystals were measured in the temperature range of 110-320 K. The electrical resistivity, charge carrier density and Hall mobility data for the crystals have been analyzed by means of existing theories and models to determine the extrinsic energy levels, the carrier effective mass, the donor and acceptor concentrations and the dominant scattering mechanism in the crystal as well. The analysis of the temperature-dependent electrical resistivity recorded parallel and perpendicular to the crystal's axis ( c-axis) reflected the existence of energy levels located at 0.26 and at 0.20 eV, respectively. The difference of these two energy levels is due to crystal anisotropy. The energy level at 0.26 eV was found to represent an acceptor level, as confirmed from Hall data analysis. The temperature dependence of the carrier density was analyzed by using the single-donor-single-acceptor model. The latter analysis revealed the carrier effective mass and the acceptor and donor concentrations as 0.73m(0), 4.10 x 10(17) cm(-3) and 1.20 x 10(17) cm(-3), respectively. The Hall mobility of TlGaTe2 is found to be limited by the scattering of hole-acoustic phonon interactions. The calculated theoretical mobility fits to the experimental one under the condition that the acoustic deformation potential is 11.0 eV, which is the energy position of the top of valence band maximum that is formed by the Te 5s states.
Citation - WoS: 3
Citation - Scopus: 4
Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients With Fmf-Related Aa Amyloidosis: a Non-Randomized 24-Week Open-Label Interventional Study
(Mdpi, 2022) Romano, Micol; Garcia-Bournissen, Facundo; Piskin, David; Rodoplu, Ulkumen; Piskin, Lizzy; Elzagallaai, Abdelbaset A.; Demirkaya, Erkan; 01. Atılım University
We aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were >18 years and had proteinuria (>3500 mg/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21-66)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis.
Citation - WoS: 1
Citation - Scopus: 1
Anticipatory Effect of Execution on Observation: an Approach Using Exopinch Finger Robot
(Tubitak Scientific & Technological Research Council Turkey, 2019) Arıkan, Kutluk Bilge; Zadeh, Hassan Gol Mohammad; Turgut, Ali Emre; Zinnuroğlu, Murat; Bayer, Gözde; Günendi, Zafer; Cengiz, Bülent; Department of Mechatronics Engineering; 01. Atılım University
Background/aim: This study aims to explore the mirror neuron system (MNS) involvement using mu (8–12 Hz)/beta (15–25 Hz) bandsuppression in an action observation-execution paradigm.Materials and methods: Electrophysiological (EEG) data from 16 electrodes were recorded while 8 participants observed video clips ofa hand squeezing a spring. Specifically, the effect of anticipated execution on observation was studied. For this purpose, a fully actuatedfinger exoskeleton robot was utilized to synchronize observation and execution and to control the execution condition for the participants. Anticipatory effect was created with a randomized robot accompany session.Results: The results showed that the observational condition (with or without anticipation) interacted with hemisphere at central channels near somatosensory cortex. Additionally, we explored the response of MNS on the kinetics features of visual stimuli (hard or softspring).Conclusion: The results showed an interaction effect of kinetics features and hemisphere at frontal channels corresponding nearly tothe ventral premotor cortex area of the brain. The activation of mirror neurons in this area plays a crucial role in observational learning.Based on our results, we propose that specific type of visual stimuli can be combined with the functional abilities of the MNS in the action observation based treatment of hand motor dysfunction of stroke patients to have a positive additional impact.
Citation - WoS: 2
Citation - Scopus: 2
Antiproliferative Activity of Platinum(ii) and Copper(ii) Complexes Containing Novel Biquinoxaline Ligands
(Oxford Univ Press, 2024) El-Beshti, Hager Sadek; Gercek, Zuhal; Kayi, Hakan; Yildizhan, Yasemin; Cetin, Yuksel; Adiguzel, Zelal; Ozalp-Yaman, Seniz; Chemical Engineering; 06. School Of Engineering; 01. Atılım University
Nowadays, cancer represents one of the major causes of death in humans worldwide, which renders the quest for new and improved antineoplastic agents to become an urgent issue in the field of biomedicine and human health. The present research focuses on the synthesis of 2,3,2MODIFIER LETTER PRIME,3MODIFIER LETTER PRIME-tetra(pyridin-2-yl)-6,6MODIFIER LETTER PRIME-biquinoxaline) and (2,3,2MODIFIER LETTER PRIME,3MODIFIER LETTER PRIME-tetra(thiophen-2-yl)-6,6MODIFIER LETTER PRIME-biquinoxaline) containing copper(II) and platinum(II) compounds as prodrug candidates. The binding interaction of these compounds with calf thymus DNA (CT-DNA) and human serum albumin were assessed with UV titration, thermal decomposition, viscometric, and fluorometric methods. The thermodynamical parameters and the temperature-dependent binding constant (KMODIFIER LETTER PRIMEb) values point out to spontaneous interactions between the complexes and CT-DNA via the van der Waals interactions and/or hydrogen bonding, except Cu(ttbq)Cl2 for which electrostatic interaction was proposed. The antitumor activity of the complexes against several human glioblastomata, lung, breast, cervix, and prostate cell lines were investigated by examining cell viability, oxidative stress, apoptosis-terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, in vitro migration and invasion, in vitro-comet DNA damage, and plasmid DNA interaction assays. The U87 and HeLa cells were investigated as the cancer cells most sensitive to our complexes. The exerted cytotoxic effect of complexes was attributed to the formation of the reactive oxygen species in vitro. It is clearly demonstrated that Cu(ttbq)Cl2, Pt(ttbq)Cl2, and Pt(tpbq)Cl2 have the highest DNA degradation potential and anticancer effect among the tested complexes by leading apoptosis. The wound healing and invasion analysis results also supported the higher anticancer activity of these two compounds. Graphical Abstract Antitumor activity of biqunoxaline complexes.
Citation - WoS: 6
Citation - Scopus: 8
Applying Emmert's Law To the Poggendorff Illusion
(Frontiers Research Foundation, 2015) Talasli, Umur; Inan, Asli Bahar; Department of Psychology; 02. School of Arts and Sciences; 01. Atılım University
The Poggendorff illusion was approached with a novel perspective, that of applying Emmert's Law to the situation. The extensities between the verticals and the transversals happen to be absolutely equal in retinal image size, whereas the registered distance for the verticals must be smaller than that of the transversals due to the fact that the former is assumed to occlude the latter. This combination of facts calls for the operation of Emmert's Law, which results in the shrinkage of the occluding space between the verticals. Since the retinal image shows the transversals to be in contact with the verticals, the shrinkage must drag the transversals inwards in the cortical representation in order to eliminate the gaps. Such dragging of the transversals produces the illusory misalignment, which is a dictation of geometry. Some of the consequences of this new explanation were tested in four different experiments. In Experiment 1, a new illusion, the tilting of an occluded continuation of an oblique line, was predicted and achieved. In Experiments 2 and 3, perceived nearness of the occluding entity was manipulated via texture density variations and the predicted misalignment variations were confirmed by using a between-subjects and within-subjects designs, respectively. In Experiment 4, tilting of the occluded segment of the transversal was found to vary in the predicted direction as a result of being accompanied by the same texture cues used in Experiments 2 and 3.
Citation - WoS: 16
Citation - Scopus: 20
Assessing the Coverage of E-Health Services in Sub-Saharan Africa a Systematic Review and Analysis
(Georg Thieme verlag Kg, 2017) Adeloye, Davies; Adigun, Taiwo; Misra, Sanjay; Omoregbe, Nicholas; Computer Engineering; 06. School Of Engineering; 01. Atılım University
Background: E-Health has attracted growing interests globally. The relative lack of facilities, skills, funds and information on existing e-Health initiatives has affected progress on e-Health in Africa. Objectives: To review publicly available literature on e-Health in sub-Saharan Africa (sSA) towards providing information on existing and ongoing e-Health initiatives in the region. Methods: Searches of relevant literature were conducted on Medline, EMBASE and Global Health, with search dates set from 1990 to 2016. We included studies on e-Health initiatives (prototypes, designs, or completed projects) targeting population groups in sSA. Results: Our search returned 2322 hits, with 26 studies retained. Included studies were conducted in 14 countries across the four sub-regions in sSA (Central, East, South and West) and spreading over a 12-year period, 2002-2014. Six types of e-Health interventions were reported, with 17 studies (65%) based on telemedicine, followed by mHealth with 5 studies (19%). Other e-Health types include expert system, electronic medical records, e-mails, and online health module. Specific medical specialties covered include dermatology (19%), pathology (12%) and radiology (8%). Successes were 'widely reported' (representing 50% overall acceptance or positive feedbacks in a study) in 10 studies (38%). The prominent challenges reported were technical problems, poor inter net and connectivity, participants' selection biases, contextual issues, and lack of funds. Conclusion: E-Health is evolving in sSA, but with poorly published evidence. While we call for more quality research in the region, it is also important that population-wide policies and on-going e-Health initiatives are contextually feasible, acceptable, and sustainable.
Citation - WoS: 1
Citation - Scopus: 1
Assessment of Anticancer Effects of Aloe Vera on 3D Liver Tumor Spheroids in a Microfluidic Platform
(Wiley, 2025) Tevlek, Atakan; Kibar, Gunes; Cetin, Barbaros; Basic Sciences; 08. Medical School; 01. Atılım University
The search for effective anticancer therapies has increasingly focused on natural compounds like Aloe vera, renowned for its therapeutic properties. This study investigates the anticancer properties of Aloe vera on 3D liver tumor spheroids via a PDMS-based microfluidic device, providing a more physiologically realistic model compared to traditional 2D cultures. HepG2 cells were cultivated to generate 3D spheroids on-chip, thereafter subjected to different concentrations of Aloe vera and the chemotherapeutic drug Doxorubicin to evaluate cytotoxic effects. The microfluidic system, validated by COMSOL simulations, facilitated continuous perfusion and real-time assessment of cell viability over a duration of 10 days. The results indicated that Aloe vera markedly diminished cell viability by triggering apoptosis at concentrations over 12.5 mg/mL. IC50 values were determined at 72 h: 25 +/- 0.10 mg/mL for Aloe vera and 5.47 +/- 0.03 mu g/mL for Doxorubicin in 2D cultures, but in 3D cultures, the IC50 values were 31.25 +/- 0.14 mg/mL for Aloe vera and 8.33 +/- 0.05 mu g/mL for Doxorubicin. This study underscores the promise of Aloe vera as a natural anticancer agent and illustrates the efficacy of microfluidic platforms for enhanced drug screening and customized medicine applications.
Citation - WoS: 5
Citation - Scopus: 5
Assessment of Nitrogen Excess in an Agricultural Area Using a Nitrogen Balance Approach
(I W A Publishing, 2005) Muhammetoglu, H; Muhammetoglu, A; Soyupak, S; 01. Atılım University
A pilot study has been initiated to develop an approach for quantification of nitrogen excesses from agricultural activities that involve greenhouse farming in Kumluca Plain, Turkey. Detailed calculations utilizing the nitrogen balance method (NBM) were carried out at nine different locations within the plain over a time period of one year. The major contributing factors and governing operative mechanisms taken into consideration were nitrogen application rates both as organic and chemical fertilizers, irrigation water to application practices, and nitrogen uptake by plants. The adopted approach yielded valuable information such as plant nitrogen uptake efficiencies, excess nitrogen, leaching rates and leachate nitrogen concentrations. Further, a site specific multiple linear regression model has been developed to estimate the ratio (N-leachate/N-groundwater) as a function of independent variables: farming age, excess nitrogen application and SEEPAGE Index Number. The negative sign of the model parameters implies that the ratio (N-leachate/N-groundwater) decreases as values of the independent variables increase. The adopted approach and the obtained results can beneficially be applied to similar sites to establish basic parameters of irrigation and fertilizer application operations.
Citation - WoS: 2
Citation - Scopus: 3
Assessment of Surrogate Markers for Cardiovascular Disease in Familial Mediterranean Fever-Related Amyloidosis Patients Homozygous for M694v Mutation in mefv Gene
(Mdpi, 2022) Sahin, Sezgin; Romano, Micol; Guzel, Ferhat; Piskin, David; Poddighe, Dimitri; Sezer, Siren; Demirkaya, Erkan; 01. Atılım University
Cardiovascular disease (CVD) remains underestimated in familial Mediterranean fever-associated AA amyloidosis (FMF-AA). We aimed to compare early markers of endothelial dysfunction and atherosclerosis in FMF-AA with a homozygous M694V mutation (Group 1 = 76 patients) in the Mediterranean fever (MEFV) gene and in patients with other genotypes (Group 2 = 93 patients). Measures of increased risk for future CVD events and endothelial dysfunction, including flow-mediated dilatation (FMD), pentraxin-3 (PTX3), and carotid intima-media thickness (cIMT), and fibroblast growth factor 23 (FGF23) as a marker of atherosclerotic vascular disease were compared between groups. The frequency of clinical FMF manifestations did not differ between the two groups apart from arthritis (76.3% in Group 1 and 59.1% in Group 2, p < 0.05). FMD was significantly lower in Group 1 when compared with Group 2 (MD [95% CI]: -0.6 [(-0.89)-(-0.31)]). cIMT, FGF23, and PTX3 levels were higher in Group 1 (cIMT MD [95% CI]: 0.12 [0.08-0.16]; FGF23 MD [95% CI]: 12.8 [5.9-19.6]; PTX3 MD [95% CI]: 13.3 [8.9-17.5]). In patients with FMF-AA, M694V homozygosity is associated with lower FMD values and higher cIMT, FGF23, and PTX3 levels, suggesting increased CVD risk profiles. These data suggest that a genotype-phenotype association exists in terms of endothelial dysfunction and atherosclerosis in patients with FMF-AA.
Citation - WoS: 3
Citation - Scopus: 3
Assessments of World and National Level Wrestling Teams at a Pre World Championship Competition: Hydration, Body Composition and Body Mass Alterations
(Edizioni Minerva Medica, 2015) Kutlu, M.; Demirkan, E.; Ozbek, M. E.; Department of Electrical & Electronics Engineering; Department of Electrical & Electronics Engineering; 15. Graduate School of Natural and Applied Sciences; 01. Atılım University
Aim. This study examined the changes in hydration status, body composition and body mass alterations during the camping period a pre world championship, World (N.=14) and National (N.=38) senior wrestlers (N.=52) preparing for the World Championships. Methods. Urine specific gravity, conductivity and color measurements with, body composition analyses were conducted at the beginning of the camp and the end of the camp. Results. In general, no significant differences were obtained between the world and national wrestlers in body mass and fat percentage (83.3 +/- 20-84.9 +/- 18 kg; 12 +/- 6%-11.2 +/- 4%, respectively). However, a significant difference was detected in the changes of body mass between groups (world decreased [800 +/- 1 g] - national increased [600 +/- 1 g] [P<0.05]). Body fat percentage was also observed to have a similar bias with a decrease and increase, but the changes were not significantly different (P>0.05). No significant differences (P>0.05) were observed between pre- and post-test values of urine specific gravity, conductivity or color for both national team wrestlers. Conclusion. Wrestlers achieved to adjust to weight category in a close of period through competition weigh in. Dehydration training programs should be sustained during the whole camp seasons including the last days before the weighing process for matches.
The Association Between Digital Device Usage Behaviors and the Incidence of De Quervain’s Tenosynovitis Among University Students
(Taylor and Francis Ltd., 2025) Jamil, Y.; Öktem, H.; Sever, S.N.; Basic Sciences; 08. Medical School; 01. Atılım University
Background: The extensive use of mobile and digital devices has been implicated in various musculoskeletal disorders, including de Quervain’s tenosynovitis (dQD), a condition affecting the thumb. Purpose: The present study investigates the relationship between digital device usage patterns and the prevalence of dQD among university students. Methods: A cross-sectional study was conducted with 508 participants (255 females and 253 males), collecting data on daily device use time, wrist positions, hand dominance, and stretching practices via a questionnaire. Data collection was carried out through a supervised, face-to-face survey. Diagnosis of dQD was determined using Finkelstein’s test, all data were analyzed using SPSS software. Results: Out of 508 participants, 187 (36.8%) tested positive for dQD, with 152 (95.6)% occurring in the dominant hand (p =.006, Cramér’s (Formula presented.) = 0.121). 250 participants used their devices with wrists in ulnar deviation (49.2%), which was strongly linked to a positive Finkelstein test result (p =.004, Cramér’s (Formula presented.) = 0.175). Finkelstein’s test showed increasing positivity with device use, ranging from 12.5% for < 2 hours to 46.2% for ≥ 8 hours, with a statistically significant association (p <.001, Cramér’s (Formula presented.) = 0.234). Device usage varied, with the highest test positivity rates among those using devices 6–8 hours per day suggesting a significant association with dQD (p =.001). No significant relationship was found between dQD and the practice of stretching or relieving movements (p =.146). Conclusion: The findings indicate that prolonged digital device usage, specific wrist positions such as ulnar deviation, and dominant-hand use are significantly associated with an increased risk of de Quervain’s tenosynovitis among college students. © 2025 Taylor & Francis Group, LLC.
Citation - Scopus: 1
Association Between Fragmented Qrs and Postprocedural Rhythm Disturbances in Patients Who Underwent Transcatheter Aortic Valve Implantation
(Assoc Medica Brasileira, 2021) Duran, Mustafa; Ziyrek, Murat; Alsancak, Yakup; Ayhan, Huseyin; 01. Atılım University
INTRODUCTION: According to recent studies, the rate of atrioventricular block requiring permanent pacing in patients following transcatheter aortic valve implantation varied between 5.7% and 42.5%. Fragmented QRS is a useful marker of myocardial scar and can predict adverse cardiac events. In this study, we examined association between fragmented QRS and postprocedural rhythm disturbances and the need for permanent pacing in patients who underwent transcatheter aortic valve implantation. OBJECTIVE: In this study, we examined association between fragmented QRS and postprocedural rhythm disturbances and the need for permanent pacing in patients who underwent transcatheter aortic valve implantation' sentence is enough for it. METHODS: We retrospectively analyzed standard 12-lead electrocardiographic recordings of 124 consecutive patients in whom a CoreValve prosthesis was implanted. We examined 12-lead electrocardiogram before and after procedure along with one- and six-month follow-up. We documented QRS fragmentation and postprocedural rhythm disturbances. RESULTS: There was a significant increase in the frequency of left bundle branch block, (21.1 versus 0%, p<0.05) and the incidence of atrioventricular blocks requiring permanent pacing (21.1 versus 0%, p<0.05) following transcatheter aortic valve implantation in patients whose preprocedural electrocardiogram recordings revealed fragmented QRS compared to those without fragmented QRS. Based our collected data, the presence of QRS fragmentation in anterior derivations was the only independent factor associated with postprocedural rhythm disturbances (B-value 0.217; OR 0.805; 95%CI 0.136-4.78; p=0.004). CONCLUSION: Our data showed an increased risk for the development of new-onset left bundle branch block and atrioventricular blocks following transcatheter aortic valve implantation in patients whose baseline electrocardiogram recordings demonstrated QRS fragmentation.
Citation - WoS: 11
Citation - Scopus: 11
Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid\raortic valve degeneration
(Tubitak Scientific & Technological Research Council Turkey, 2020) Karaduman, Bilge Duran; Ayhan, Hüseyin; Keles, Telat; Bozkurt, Engin; 01. Atılım University
Background/aim: From a pathophysiological point of view, inflammation is thought to be more dominant in bicuspid aortic valve\r(BAV) stenosis than tricuspid aortic valve (TAV) stenosis. Our study aimed to determine the association between monocyte to highdensity lipoprotein cholesterol (HDL-C) ratio (MHR), a new inflammatory marker, and the speed of progression of stenosis and\rpathophysiology of BAV stenosis.\rMaterials and methods: A total of 210 severe aortic stenosis patients (70 consecutive BAV patients, 140 matched TAV patients) were\rretrospectively enrolled in the study. Clinical and echocardiographic data and laboratory results related to our research were collected\rretrospectively from the patients’ records. MHR was measured as the ratio of the absolute monocyte count to the HDL-C value.\rResults: Seventy BAV (mean age: 72.0 ± 9.1 years, 42.9% female) and 140 TAV patients (mean age: 77.9 ± 8.3 years, 51.4% female)\rwith severe aortic stenosis were enrolled in this study. There was no difference between the two groups in terms of another baseline\rdemographic or clinic findings except age (P < 0.001). Monocyte count, hemoglobin level, mean platelet volume was significantly\rhigher, and HDL-C level was significantly lower in the BAV group, while other lipid and CBC parameters were found to be similar. In\rthe multivariate analysis, MHR (P = 0.005, 95% CI: 0.90–0.98) and, as expected, age (P = 0.001, 95% CI: 1.02–1.11) were found to be\rsignificant as the independent predictor of BAV, after adjusting for other risk factors.\rConclusion: Our study showed a significant correlation between increased MHR and BAV. MHR was determined as a significant\rindependent predictor for the speed of progression and diagnosis of severe BAV stenosis in multivariate analysis.
Citation - WoS: 2
Citation - Scopus: 1
Association Between the Degree of Nonalcoholic Fatty Liver Disease and Nocturnal Hypertension
(Lippincott Williams & Wilkins, 2025) Astan, Ramazan; Kacmaz, Fehmi; Saricam, Ersin; Ozyer, Esref Umut; Ilkay, Erdogan; 01. Atılım University
Nighttime blood pressure (BP) decreases have prognostic significance owing to circadian patterns. The prevalence of nonalcoholic fatty liver disease (NAFLD) has rapidly increased in recent years. We aimed to investigate circadian blood pressure changes in patients with NAFLD. The present study included 114 patients diagnosed with nonalcoholic fatty liver disease and no previous hypertension diagnosis. Thirty patients comprised the control group (no hepatosteatosis and no hypertension). The patients were divided into 3 groups based on nocturnal BP dipping. Blood pressure patterns using night-day ratios were classified as dipper (ratio <= 0, 9), nondipper (0, 9 < ratio <= 1, 0), or nocturnal hypertension (ratio > 1, 0). There were no significant differences in sex, age, presence of diabetes, or biochemical test results between the groups. According to the blood pressure pattern, the nondipper rate in the hepatosteatosis group was significantly higher than that in the control group. Patients were compared in terms of the presence and severity of hepatosteatosis according to night blood pressure patterns. A significant difference was observed between the groups (P < .001 and P = .001, respectively). We found an association between hepatosteatosis severity and night blood pressure patterns. Patients with nonalcoholic fatty liver disease have a higher incidence of nocturnal hypertension. We observed impaired circadian blood pressure changes in patients with nonalcoholic fatty liver disease.
Autologous Peripheral Blood Stem Cell Mobilization and Apheresis in Pediatric Patients With Cancer: a Single-Center Report of 64 Procedures
(Wiley, 2024) Erdem, Arzu Yazal; Ozyoruk, Derya; Bozkaya, Ikbal Ok; Cakmakci, Selma; Emir, Suna; Demir, Haci Ahmet; Ozbek, Namik Yasar; 01. Atılım University
Background The published experience concerning autologous peripheral blood stem cell collection in children is very limited. Methods The data of pediatric patients who underwent autologous stem cell mobilization and apheresis between January 2011 and April 2020 were analyzed retrospectively. Results We studied retrospectively 64 mobilization and apheresis procedures in 48 pediatric patients (34 males, 14 females), mean age of 7.31 +/- 5.38 (range, 1.5-19.7) years, the underlying disease was mostly neuroblastoma (NBL). The body weight of 21 patients (43.75%) was 15 kg or less. The targeted autologous peripheral stem cell apheresis (APSCA) was successfully achieved in 98% of patients. Neuroblastoma patients were younger than the rest of the patients and underwent apheresis after receiving fewer chemotherapy cycles than others and all of them mobilized within the first session successfully. Plerixafor was added to mobilization in nine heavily pretreated patients (18.7%), median two doses (range, 1-4 doses). 11 patients (22.9%) underwent radiotherapy (RT) before mobilization with doses of median 24 Gy (range, 10.8-54.0 Gy). Patients with RT were older at the time of apheresis and had received more chemotherapy courses than patients without RT. As a result, patients with a history of RT had significantly lower peripheral CD34+ cells and CD34+ yields than those without RT. In 17 patients (35.4%), 22 different complications were noted. The most common complications were catheter-related infections (n:10, 20.8%), followed by catheter-related thrombosis in eight patients (16.7%). Conclusions Patients who had far less therapy before apheresis were more likely to mobilize successfully. Our study provides a detailed practice approach including complications during APSCA aiming to increase the success rates of apheresis in transplantation centers.
Baby Steps of Parenting: Turkish Adaptation of Infancy Parenting Styles Questionnaire and Mother- and Infant-Related Characteristics Affecting Parenting in Infancy
(Wiley, 2025) Bahtiyar-Saygan, Bahar; Department of Psychology; 02. School of Arts and Sciences; 01. Atılım University
The crucial importance of parenting for human development is well known, yet there has been little investigation, particularly regarding infancy parenting. This study investigates mother- and infant-related characteristics affecting parenting styles in the first year after birth. Additionally, adapting an Infancy Parenting Styles Questionnaire (IPSQ) to Turkish is aimed. In total, 110 mothers with babies in the first year of their lives (M age in months = 6.39, SDage in months = 3.72; 70 girls) participated in the study. Mothers filled out the IPSQ, Early Parenting Attitudes Questionnaire (EPAQ), Karitane Parental Self-Confidence Scale (KPSC), and Parental Stress Index-Short Form (PSI-SF). Four components emerged: involvement, discipline, anxiety, and routine. The IPSQ was found to be reliable (alpha = .81) and valid. The findings revealed that income, the number of children, and parental confidence were significant predictors for involvement; maternal education, parental confidence, parenting stress, and sleep wellness of the baby were significant predictors for discipline; and the number of caregivers and parental confidence were significant predictors for routine sub-components. Also, results indicated higher involvement and lower discipline in primiparous compared to multiparous mothers. The findings were discussed in light of the literature regarding the antecedents of parenting and its developmental outcomes.

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