Hybrid Polymeric Scaffolds Prepared by Micro and Macro Approaches

dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorid Ozkan, Ozan/0000-0002-9050-1583
dc.authorscopusid 57189848353
dc.authorscopusid 16680382000
dc.contributor.author Ozkan, Ozan
dc.contributor.author Sasmazel, Hilal Turkoglu
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T15:16:17Z
dc.date.available 2024-07-05T15:16:17Z
dc.date.issued 2017
dc.department Atılım University en_US
dc.department-temp [Ozkan, Ozan] Hacettepe Univ, Bioengn Div, Ankara, Turkey; [Sasmazel, Hilal Turkoglu] Atilim Univ, Dept Met & Mat Engn, TR-06836 Ankara, Turkey en_US
dc.description Turkoglu Sasmazel, Hilal/0000-0002-0254-4541; Ozkan, Ozan/0000-0002-9050-1583 en_US
dc.description.abstract Polymeric scaffolds with complex porous structures were fabricated with two different polymers by combining three fabrication methods in three steps, in which, nonwoven poly(e-caprolactone) microfibers were obtained with electrospinning and immersed in solvent cast chitosan solution poured in Petri dish to fabricate hybrid polymers, and finally the combined structure was freeze-dried with two different predrying techniques to obtain macropores in the structure. The resulting hybrid polymeric mats were found to have both microfibers and macroporosity due to the electrospinning as well as freeze-drying processes, which resemble the natural extracellular matrix. The optimized scaffolds that predried in the incubator at 40 degrees C for 5 h and then freeze-dried for 24 h exhibited contact angle value of 68.93 +/- 2.18 degrees with 3.252 +/- 0.783 MPa Young's modulus and 0.260 +/- 0.002 MPa yield strength as well as 1.35-fold cell yield in MRC5 fibroblast cell culture, compared to the commercial tissue culture polystyrene. [GRAPHICS] . en_US
dc.identifier.citationcount 7
dc.identifier.doi 10.1080/00914037.2016.1278218
dc.identifier.endpage 860 en_US
dc.identifier.issn 0091-4037
dc.identifier.issn 1563-535X
dc.identifier.issue 16 en_US
dc.identifier.scopus 2-s2.0-85028598704
dc.identifier.startpage 853 en_US
dc.identifier.uri https://doi.org/10.1080/00914037.2016.1278218
dc.identifier.uri https://hdl.handle.net/20.500.14411/1622
dc.identifier.volume 66 en_US
dc.identifier.wos WOS:000416503300006
dc.institutionauthor Özkan, Ozan
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Taylor & Francis As en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 7
dc.subject Chitosan en_US
dc.subject electrospinning en_US
dc.subject freeze-drying en_US
dc.subject MRC5 fibroblasts en_US
dc.subject PCL en_US
dc.subject solvent casting en_US
dc.title Hybrid Polymeric Scaffolds Prepared by Micro and Macro Approaches en_US
dc.type Article en_US
dc.wos.citedbyCount 6
dspace.entity.type Publication
relation.isAuthorOfPublication 741bfc12-0d53-48d4-bfa2-08290dbfcbeb
relation.isAuthorOfPublication 89a1446a-af3c-4bd3-a3f6-5f29625b68fd
relation.isAuthorOfPublication.latestForDiscovery 741bfc12-0d53-48d4-bfa2-08290dbfcbeb
relation.isOrgUnitOfPublication 7cf7435b-3e8e-404e-adee-0f6f7dc8e070
relation.isOrgUnitOfPublication.latestForDiscovery 7cf7435b-3e8e-404e-adee-0f6f7dc8e070

Files

Collections