Determinants of Mortality in a Large Group of Hemodialysis Patients Hospitalized for Covid-19

dc.authorid sezer, siren/0000-0002-7326-8388
dc.authorid Ozturk, Savas/0000-0002-0961-3810
dc.authorid Ayar, Yavuz/0000-0003-4607-9220
dc.authorid Kazancıoğlu, Rümeyza/0000-0003-1217-588X
dc.authorid islam, Mahmud/0000-0003-1284-916X
dc.authorid Ayar, Yavuz/0000-0003-4607-9220
dc.authorid turgutalp, kenan/0000-0003-0245-1844
dc.authorscopusid 36085801700
dc.authorscopusid 35264796700
dc.authorscopusid 36338307600
dc.authorscopusid 55974394500
dc.authorscopusid 26648679600
dc.authorscopusid 57220973674
dc.authorscopusid 6701485435
dc.authorwosid sezer, siren/JYQ-2550-2024
dc.authorwosid Ozturk, Savas/AAE-6049-2021
dc.authorwosid Ayar, Yavuz/GSE-0029-2022
dc.authorwosid Kazancıoğlu, Rümeyza/AAH-7666-2019
dc.authorwosid islam, Mahmud/HHS-1422-2022
dc.authorwosid Ayar, Yavuz/O-9948-2015
dc.authorwosid SENGUL, Erkan/J-8295-2012
dc.contributor.author Turgutalp, Kenan
dc.contributor.author Ozturk, Savas
dc.contributor.author Arici, Mustafa
dc.contributor.author Eren, Necmi
dc.contributor.author Gorgulu, Numan
dc.contributor.author Islam, Mahmut
dc.contributor.author Ates, Kenan
dc.date.accessioned 2024-07-05T15:18:38Z
dc.date.available 2024-07-05T15:18:38Z
dc.date.issued 2021
dc.department Atılım University en_US
dc.department-temp [Turgutalp, Kenan] Mersin Univ, Dept Nephrol, Fac Med, Mersin, Turkey; [Ozturk, Savas; Uzun, Sami] Haseki Training & Res Hosp, Dept Nephrol, Istanbul, Turkey; [Arici, Mustafa] Hacettepe Univ, Dept Nephrol, Fac Med, Ankara, Turkey; [Eren, Necmi] Kocaeli Univ, Dept Nephrol, Fac Med, Kocaeli, Turkey; [Gorgulu, Numan] Univ Hlth Sci, Bagcilar Training & Res Hosp, Div Nephrol, Dept Internal Med, Istanbul, Turkey; [Islam, Mahmut] Zonguldak Ataturk State Hosp, Dept Nephrol, Zonguldak, Turkey; [Sakaci, Tamer] Hlth Sci Univ, Sisli Hamidiye Etfal Educ & Res Hosp, Dept Nephrol, Istanbul, Turkey; [Aydin, Zeki] Darica Farabi Training & Res Hosp, Dept Nephrol, Kocaeli, Turkey; [Sengul, Erkan] Hlth Sci Univ, Kocaeli Derince Educ & Res Hosp, Div Nephrol, Kocaeli, Turkey; [Demirelli, Bulent] Univ Hlth Sci, Haydarpasa Numune Educ & Res Hosp, Dept Nephrol, Istanbul, Turkey; [Ayar, Yavuz] Bursa City Hosp, Dept Nephrol, Bursa, Turkey; [Altiparmak, Mehmet Riza] Istanbul Univ Cerrahpasa, Dept Internal Med, Div Nephrol, Cerrahpasa Fac Med, Istanbul, Turkey; [Sipahi, Savas] Sakarya Univ, Dept Internal Med, Div Nephrol, Fac Med Educ & Res Hosp, Sakarya, Turkey; [Mentes, Ilay Berke] Marmara Univ, Dept Internal Med, Div Nephrol, Sch Med,Pendik Educ & Res Hosp, Istanbul, Turkey; [Ozler, Tuba Elif] Kanuni Sultan Suleyman Res & Training Hosp, Dept Internal Med, Div Nephrol, Istanbul, Turkey; [Oguz, Ebru Gok] Univ Hlth Sci, Dept Nephrol, Diskapi Yildirim Beyazit Educ & Res Hosp, Ankara, Turkey; [Huddam, Bulent] Mugla Sitki Kocman Univ, Dept Internal Med, Div Nefrol, Fac Med Educ & Res Hosp, Mugla, Turkey; [Hur, Ender] Manisa Merkezefendi State Hosp, Dept Nephrol, Manisa, Turkey; [Kazancioglu, Rumeyza] Bezmialem Vakif Univ, Dept Internal Med, Div Nephrol, Istanbul, Turkey; [Gungor, Ozkan] Kahramanmaras Sutcu Imam Univ, Dept Nephrol, Fac Med, Kahramanmaras, Turkey; [Tokgoz, Bulent] Erciyes Univ, Sch Med, Dept Nephrol, Kayseri, Turkey; [Tonbul, Halil Zeki] Necmettin Erbakan Univ, Div Nephrol, Dept Internal Med, Konya, Turkey; [Yildiz, Alaattin] Istanbul Univ, Dept Internal Med, Div Nephrol, Istanbul Sch Med, Istanbul, Turkey; [Sezer, Siren] Atilim Univ, Dept Internal Med & Nephrol, Fac Med, Ankara, Turkey; [Odabas, Ali Riza] Univ Hlth Sci, Dept Nephrol, Sultan Abdulhamid Han Training & Res Hosp, Istanbul, Turkey; [Ates, Kenan] Ankara Univ, Fac Med, Dept Nephrol, Ankara, Turkey en_US
dc.description sezer, siren/0000-0002-7326-8388; Ozturk, Savas/0000-0002-0961-3810; Ayar, Yavuz/0000-0003-4607-9220; Kazancıoğlu, Rümeyza/0000-0003-1217-588X; islam, Mahmud/0000-0003-1284-916X; Ayar, Yavuz/0000-0003-4607-9220; Ayar, Yavuz/0000-0003-4607-9220; ARICI, MUSTAFA/0000-0002-4055-7896; berke, ilay/0000-0001-7610-7830; uzun, sami/0000-0002-7843-164X; hur, ender/0000-0002-8066-4629; Altiparmak, Mehmet Riza/0000-0002-3579-1100; turgutalp, kenan/0000-0003-0245-1844 en_US
dc.description.abstract Background: Maintenance hemodialysis (MHD) patients are at increased risk for coronavirus disease 2019 (COVID-19). The aim of this study was to describe clinical, laboratory, and radiologic characteristics and determinants of mortality in a large group of MHD patients hospitalized for COVID-19. Methods: This multicenter, retrospective, observational study collected data from 47 nephrology clinics in Turkey. Baseline clinical, laboratory and radiological characteristics, and COVID-19 treatments during hospitalization, need for intensive care and mechanical ventilation were recorded. The main study outcome was in-hospital mortality and the determinants were analyzed by Cox regression survival analysis. Results: Of 567 MHD patients, 93 (16.3%) patients died, 134 (23.6%) patients admitted to intensive care unit (ICU) and 91 of the ones in ICU (67.9%) needed mechanical ventilation. Patients who died were older (median age, 66 [57-74] vs. 63 [52-71] years, p = 0.019), had more congestive heart failure (34.9% versus 20.7%, p = 0.004) and chronic obstructive pulmonary disease (23.6% versus 12.7%, p = 0.008) compared to the discharged patients. Most patients (89.6%) had radiological manifestations compatible with COVID-19 pulmonary involvement. Median platelet (166 x 10(3) per mm(3) versus 192 x 10(3) per mm(3), p = 0.011) and lymphocyte (800 per mm(3) versus 1000 per mm(3), p < 0.001) counts and albumin levels (median, 3.2 g/dl versus 3.5 g/dl, p = 0.001) on admission were lower in patients who died. Age (HR: 1.022 [95% CI, 1.003-1.041], p = 0.025), severe-critical disease clinical presentation at the time of diagnosis (HR: 6.223 [95% CI, 2.168-17.863], p < 0.001), presence of congestive heart failure (HR: 2.247 [95% CI, 1.228-4.111], p = 0.009), ferritin levels on admission (HR; 1.057 [95% CI, 1.006-1.111], p = 0.028), elevation of aspartate aminotransferase (AST) (HR; 3.909 [95% CI, 2.143-7.132], p < 0.001) and low platelet count (< 150 x 10(3) per mm(3)) during hospitalization (HR; 1.864 [95% CI, 1.025-3.390], p = 0.041) were risk factors for mortality. Conclusion: Hospitalized MHD patients with COVID-19 had a high mortality rate. Older age, presence of heart failure, clinical severity of the disease at presentation, ferritin level on admission, decrease in platelet count and increase in AST level during hospitalization may be used to predict the mortality risk of these patients. en_US
dc.description.sponsorship Turkish Society of Nephrology en_US
dc.description.sponsorship The study was funded by Turkish Society of Nephrology. en_US
dc.identifier.citationcount 45
dc.identifier.doi 10.1186/s12882-021-02233-0
dc.identifier.issn 1471-2369
dc.identifier.issue 1 en_US
dc.identifier.pmid 33446135
dc.identifier.scopus 2-s2.0-85099383830
dc.identifier.uri https://doi.org/10.1186/s12882-021-02233-0
dc.identifier.uri https://hdl.handle.net/20.500.14411/1880
dc.identifier.volume 22 en_US
dc.identifier.wos WOS:000607858600001
dc.identifier.wosquality Q3
dc.language.iso en en_US
dc.publisher Bmc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 54
dc.subject Hemodialysis en_US
dc.subject COVID-19 en_US
dc.subject Radiological manifestations en_US
dc.subject Mortality en_US
dc.subject Clinical findings en_US
dc.title Determinants of Mortality in a Large Group of Hemodialysis Patients Hospitalized for Covid-19 en_US
dc.type Article en_US
dc.wos.citedbyCount 46
dspace.entity.type Publication

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