Development of Amoxicillin-Loaded Electrospun Polyurethane/Chitosan/ β-Tricalcium Phosphate Scaffold for Bone Tissue Regeneration
dc.authorid | Gunduz, Oguzhan/0000-0002-4926-6489 | |
dc.authorid | Uzun, Muhammet/0000-0001-8669-7686 | |
dc.authorid | Altun, Esra/0000-0002-5446-1465 | |
dc.authorid | Ikram, Fakhera/0000-0001-7796-4746 | |
dc.authorid | Gunduz, Oguzhan/0000-0002-9427-7574 | |
dc.authorid | Turkoglu Sasmazel, Hilal/0000-0002-0254-4541 | |
dc.authorscopusid | 57202390255 | |
dc.authorscopusid | 37032986900 | |
dc.authorscopusid | 57202395225 | |
dc.authorscopusid | 57202390232 | |
dc.authorscopusid | 57200305151 | |
dc.authorscopusid | 6603890996 | |
dc.authorscopusid | 16680382000 | |
dc.authorwosid | Gunduz, Oguzhan/AAA-3212-2019 | |
dc.authorwosid | Uzun, Muhammet/AAD-9551-2019 | |
dc.authorwosid | Altun, Esra/KIA-4323-2024 | |
dc.authorwosid | Gunduz, Oguzhan/E-5292-2011 | |
dc.contributor.author | Uzun, Muhammet | |
dc.contributor.author | Uzun, Muhammet | |
dc.contributor.author | Ugar, Gaye | |
dc.contributor.author | Ozcan, Aslihan | |
dc.contributor.author | Altun, Esra | |
dc.contributor.author | Oktar, Faik Nuzhet | |
dc.contributor.author | Gunduz, Oguzhan | |
dc.date.accessioned | 2024-07-05T15:27:01Z | |
dc.date.available | 2024-07-05T15:27:01Z | |
dc.date.issued | 2018 | |
dc.department | Atılım University | en_US |
dc.department-temp | [Topsakal, Aysenur; Altun, Esra; Gunduz, Oguzhan] Marmara Univ, Fac Technol, Met & Mat Engn Dept, Goztepe Campus, TR-34722 Istanbul, Turkey; [Topsakal, Aysenur; Altun, Esra; Gunduz, Oguzhan] Marmara Univ, Fac Technol, Adv Nanomat Res Lab, Goztepe Campus, TR-34722 Istanbul, Turkey; [Uzun, Muhammet; Oktar, Faik Nuzhet] Marmara Univ, Fac Technol, Text Engn Dept, Goztepe Campus, TR-34722 Istanbul, Turkey; [Ugar, Gaye; Ozcan, Aslihan; Oktar, Faik Nuzhet] Marmara Univ, Fac Engn, Bioengn Dept, Goztepe Campus, TR-34722 Istanbul, Turkey; [Ikram, Fakhera] COMSATS Inst Informat Technol, Interdisciplinary Res Ctr Biomed Mat, Lahore 45550, Pakistan; [Ozkan, Ozan] Hacettepe Univ, Grad Sch Sci & Engn, Bioengn Div, TR-06800 Ankara, Turkey; [Sasmazel, Hilal Turkoglu] Atilim Univ, Fac Engn, Met & Mat Engn Dept, TR-06830 Ankara, Turkey | en_US |
dc.description | Gunduz, Oguzhan/0000-0002-4926-6489; Uzun, Muhammet/0000-0001-8669-7686; Altun, Esra/0000-0002-5446-1465; Ikram, Fakhera/0000-0001-7796-4746; Gunduz, Oguzhan/0000-0002-9427-7574; Turkoglu Sasmazel, Hilal/0000-0002-0254-4541 | en_US |
dc.description.abstract | Biocompatible nanocomposite electrospun fibers containing Polyurethane/Chitosan/beta-Tri calcium phosphate with diverse concentrations were designed and produced through the electrospinning process for bone tissue engineering applications. After the production process, density measurement, viscosity, electrical conductivity, and tensile strength measurement tests were carried out as physical analyses of blended solutions. The chemical structural characterization was scrutinized using Fourier transform infrared spectrometer (FTIR), and scanning electron microscopy (SEM) was used to observe the morphological details of developed electrospun scaffolds. Cell viability, attachment, and proliferation were performed using a L929 fibroblast cell line. Based on the physical, SEM, FTIR analysis, and cell culture studies, preferable nanofiber composition was selected for further studies. Amoxicillin (AMX) was loaded to that selected nanofiber composition for examination of the drug release. In comparison with other studies on similar AMX controlled products, higher drug loading and encapsulation efficiencies were obtained. It has been clearly found that the developed nanofiber composites have potential for bone tissue engineering applications. | en_US |
dc.description.sponsorship | BAPKO, Marmara University [SAG-B-09022017-0036] | en_US |
dc.description.sponsorship | This work was founded by BAPKO, Marmara University, under Grant SAG-B-09022017-0036. | en_US |
dc.identifier.citation | 17 | |
dc.identifier.doi | 10.1109/TNB.2018.2844870 | |
dc.identifier.endpage | 328 | en_US |
dc.identifier.issn | 1536-1241 | |
dc.identifier.issn | 1558-2639 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 29994218 | |
dc.identifier.scopus | 2-s2.0-85048172338 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 321 | en_US |
dc.identifier.uri | https://doi.org/10.1109/TNB.2018.2844870 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14411/2631 | |
dc.identifier.volume | 17 | en_US |
dc.identifier.wos | WOS:000440680400018 | |
dc.identifier.wosquality | Q2 | |
dc.language.iso | en | en_US |
dc.publisher | Ieee-inst Electrical Electronics Engineers inc | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Bone tissue engineering | en_US |
dc.subject | chitosan | en_US |
dc.subject | electrospinning | en_US |
dc.subject | polyurethane | en_US |
dc.subject | tricalcium phosphate | en_US |
dc.title | Development of Amoxicillin-Loaded Electrospun Polyurethane/Chitosan/ β-Tricalcium Phosphate Scaffold for Bone Tissue Regeneration | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 2d529904-f2a0-4c48-bc92-81abcf9b96e9 | |
relation.isAuthorOfPublication.latestForDiscovery | 2d529904-f2a0-4c48-bc92-81abcf9b96e9 |