Impact of Vaccination on the Presence and Severity of Symptoms in Hospitalized Patients With an Infection of the Omicron Variant (b.1.1.529) of the Sars-Cov (subvariant Ba.1)

dc.authoridBeraud, Guillaume/0000-0002-4705-0916
dc.authoridEpaulard, Olivier/0000-0001-8282-9522
dc.authoridCivljak, Rok/0000-0001-8766-7438
dc.authoridVelikov, Petar/0000-0002-7436-4064
dc.authoridYarimoglu, Saliha/0000-0001-7081-9474
dc.authoridBlanchi, Sophie/0009-0008-9323-5947
dc.authoridSvitek, Luka/0000-0003-0208-5821
dc.authorscopusid26532350500
dc.authorscopusid57743402000
dc.authorscopusid7801604292
dc.authorscopusid36646442100
dc.authorscopusid6602738477
dc.authorscopusid57213152361
dc.authorscopusid57531748500
dc.authorwosidBeraud, Guillaume/O-6062-2017
dc.authorwosidEpaulard, Olivier/AHD-4798-2022
dc.authorwosidCivljak, Rok/AAL-4002-2020
dc.authorwosidVelikov, Petar/IRZ-9215-2023
dc.authorwosidAbgrall, Sophie/HTQ-2825-2023
dc.contributor.authorBeraud, Guillaume
dc.contributor.authorBouetard, Laura
dc.contributor.authorCivljak, Rok
dc.contributor.authorMichon, Jocelyn
dc.contributor.authorTulek, Necla
dc.contributor.authorLejeune, Sophie
dc.contributor.authorEpaulard, Olivier
dc.contributor.otherBasic Sciences
dc.date.accessioned2024-07-05T15:25:17Z
dc.date.available2024-07-05T15:25:17Z
dc.date.issued2023
dc.departmentAtılım Universityen_US
dc.department-temp[Beraud, Guillaume; Millot, Romain] Univ Hosp Poitiers, Dept Infect Dis, 2 Rue Miletrie, F-86000 Poitiers, France; [Bouetard, Laura; Abgrall, Sophie] Hop Antoine Beclere, Assistance Publ Hop Paris, Serv Med Interne, Clamart, France; [Bouetard, Laura; Abgrall, Sophie] Univ Versailles St Quentin En Yvelines, Univ Paris Saclay, INSERM U1018, Ctr Rech Epidemiol & Sante Populat, Le Kremlin Bicetre, France; [Civljak, Rok; Lizatovic, Ivan K.] Univ Hosp Infect Dis Dr Fran Mihaljevic Zagreb, Zagreb, Croatia; [Civljak, Rok] Univ Zagreb, Sch Med, Zagreb, Croatia; [Michon, Jocelyn; Boldolli, Aurelie] Univ Hosp Caen, Dept Infect Dis, Caen, France; [Tulek, Necla; Esmer, Huseyin] Atilim Univ, Dept Infect Dis & Clin Microbiol, Ankara Training & Res Hosp, Ankara, Turkiye; [Lejeune, Sophie; Epaulard, Olivier] Ctr Hosp Univ Grenoble Alpes, Infect Dis, Grenoble, France; [Garchet-Beaudron, Aurelie; Blanchi, Sophie] Ctr Hosp, Dept Infect Dis, Le Mans, France; [Lefebvre, Maeva; Froidevaux, Gabrielle] Ctr Hosp Univ Nantes, Dept Infect Dis, Ctr Prevent Infect & Transmissible Dis, Nantes, France; [Lefebvre, Maeva] Nantes Univ, INSERM, Ctr Invest Clin 1413, Nantes, France; [Velikov, Petar; Kapincheva, Nikol] Med Univ Sofia, Infect Dis Hosp Prof Ivan Kirov, Sofia, Bulgaria; [Festou, Benjamin; Faucher, Jean-Francois] Ctr Hosp Univ Limoges, Dept Infect Dis & Trop Med, Limoges, France; [Faucher, Jean-Francois] INSERM U1094, Limoges, France; [Duvnjak, Mario; Svitek, Luka] Univ Hosp Ctr Osijek, Clin Infect Dis, Osijek, Croatia; [Duvnjak, Mario; Svitek, Luka] JJ Strossmayer Univ Osijek, Fac Med Osijek, Osijek, Croatia; [Afsar, Elcin] Atilim Univ, Vocat Sch Hlth Serv, Ankara, Turkiye; [Yarimoglu, Saliha; Yarimoglu, Rafet] Karaman Training & Res Hosp, Karaman, Turkiye; [Janssen, Cecile] Ctr Hosp Annecy Genevois, Infect Dis Unit, Annecy, Franceen_US
dc.descriptionBeraud, Guillaume/0000-0002-4705-0916; Epaulard, Olivier/0000-0001-8282-9522; Civljak, Rok/0000-0001-8766-7438; Velikov, Petar/0000-0002-7436-4064; Yarimoglu, Saliha/0000-0001-7081-9474; Blanchi, Sophie/0009-0008-9323-5947; Svitek, Luka/0000-0003-0208-5821en_US
dc.description.abstractObjectives: The emergence of SARS-CoV-2 variants raised questions about the extent to which vaccines designed in 2020 have remained effective. We aimed to assess whether vaccine status was associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients.Methods: We conducted an international, multi-centric, retrospective study in 14 centres (Bulgaria, Croatia, France, and Turkey). We collected data on patients hospitalized for >= 24 hours between 1 December 2021 and 3 March 2022 with PCR-confirmed infection at a time of exclusive Omicron circu-lation and hospitalization related or not related to the infection. Patients who had received prophylaxis by monoclonal antibodies were excluded. Patients were considered fully vaccinated if they had received at least two injections of either mRNA and/or ChAdOx1-S or one injection of Ad26.CoV2-S vaccines. Results: Among 1215 patients (median age, 73.0 years; interquartile range, 57.0-84.0; 51.3% men), 746 (61.4%) were fully vaccinated. In multivariate analysis, being vaccinated was associated with lower 28 -day mortality (Odds Ratio [95% Confidence Interval] (OR [95CI]) = 0.50 [0.32-0.77]), intensive care unit admission (OR [95CI] = 0.40 [0.26-0.62]), and oxygen requirement (OR [95CI] = 0.34 [0.25-0.46]), independent of age and comorbidities. When co-analysing these patients with Omicron infection with 948 patients with Delta infection from a study we recently conducted, Omicron infection was associated with lower 28-day mortality (OR [95CI] = 0.53 [0.37-0.76]), intensive care unit admission (OR [95CI] = 0.19 [0.12-0.28]), and oxygen requirements (OR [95CI] = 0.50 [0.38-0.67]), independent of age, comorbidities, and vaccination status.Discussion: Originally designed vaccines have remained effective on the severity of Omicron SARS-CoV-2 infection. Omicron is associated with a lower risk of severe forms, independent of vaccination and pa-tient characteristics. Guillaume Beraud, Clin Microbiol Infect 2023;29:642 (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.identifier.citationcount4
dc.identifier.doi10.1016/j.cmi.2022.12.020
dc.identifier.endpage650en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue5en_US
dc.identifier.pmid36587737
dc.identifier.scopus2-s2.0-85147890026
dc.identifier.scopusqualityQ1
dc.identifier.startpage642en_US
dc.identifier.urihttps://doi.org/10.1016/j.cmi.2022.12.020
dc.identifier.urihttps://hdl.handle.net/20.500.14411/2529
dc.identifier.volume29en_US
dc.identifier.wosWOS:000986698700001
dc.identifier.wosqualityQ1
dc.institutionauthorTülek, Necla
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.scopus.citedbyCount6
dc.subjectBreakthrough infectionen_US
dc.subjectOmicronen_US
dc.subjectSARS-CoV-2en_US
dc.titleImpact of Vaccination on the Presence and Severity of Symptoms in Hospitalized Patients With an Infection of the Omicron Variant (b.1.1.529) of the Sars-Cov (subvariant Ba.1)en_US
dc.typeArticleen_US
dc.wos.citedbyCount6
dspace.entity.typePublication
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