Impact of Vaccination on the Presence and Severity of Symptoms in Hospitalized Patients With an Infection of the Omicron Variant (b.1.1.529) of the Sars-Cov (subvariant Ba.1)

dc.authorid Beraud, Guillaume/0000-0002-4705-0916
dc.authorid Epaulard, Olivier/0000-0001-8282-9522
dc.authorid Civljak, Rok/0000-0001-8766-7438
dc.authorid Velikov, Petar/0000-0002-7436-4064
dc.authorid Yarimoglu, Saliha/0000-0001-7081-9474
dc.authorid Blanchi, Sophie/0009-0008-9323-5947
dc.authorid Svitek, Luka/0000-0003-0208-5821
dc.authorscopusid 26532350500
dc.authorscopusid 57743402000
dc.authorscopusid 7801604292
dc.authorscopusid 36646442100
dc.authorscopusid 6602738477
dc.authorscopusid 57213152361
dc.authorscopusid 57531748500
dc.authorwosid Beraud, Guillaume/O-6062-2017
dc.authorwosid Epaulard, Olivier/AHD-4798-2022
dc.authorwosid Civljak, Rok/AAL-4002-2020
dc.authorwosid Velikov, Petar/IRZ-9215-2023
dc.authorwosid Abgrall, Sophie/HTQ-2825-2023
dc.contributor.author Beraud, Guillaume
dc.contributor.author Bouetard, Laura
dc.contributor.author Civljak, Rok
dc.contributor.author Michon, Jocelyn
dc.contributor.author Tulek, Necla
dc.contributor.author Lejeune, Sophie
dc.contributor.author Epaulard, Olivier
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:25:17Z
dc.date.available 2024-07-05T15:25:17Z
dc.date.issued 2023
dc.department Atılım University en_US
dc.department-temp [Beraud, Guillaume; Millot, Romain] Univ Hosp Poitiers, Dept Infect Dis, 2 Rue Miletrie, F-86000 Poitiers, France; [Bouetard, Laura; Abgrall, Sophie] Hop Antoine Beclere, Assistance Publ Hop Paris, Serv Med Interne, Clamart, France; [Bouetard, Laura; Abgrall, Sophie] Univ Versailles St Quentin En Yvelines, Univ Paris Saclay, INSERM U1018, Ctr Rech Epidemiol & Sante Populat, Le Kremlin Bicetre, France; [Civljak, Rok; Lizatovic, Ivan K.] Univ Hosp Infect Dis Dr Fran Mihaljevic Zagreb, Zagreb, Croatia; [Civljak, Rok] Univ Zagreb, Sch Med, Zagreb, Croatia; [Michon, Jocelyn; Boldolli, Aurelie] Univ Hosp Caen, Dept Infect Dis, Caen, France; [Tulek, Necla; Esmer, Huseyin] Atilim Univ, Dept Infect Dis & Clin Microbiol, Ankara Training & Res Hosp, Ankara, Turkiye; [Lejeune, Sophie; Epaulard, Olivier] Ctr Hosp Univ Grenoble Alpes, Infect Dis, Grenoble, France; [Garchet-Beaudron, Aurelie; Blanchi, Sophie] Ctr Hosp, Dept Infect Dis, Le Mans, France; [Lefebvre, Maeva; Froidevaux, Gabrielle] Ctr Hosp Univ Nantes, Dept Infect Dis, Ctr Prevent Infect & Transmissible Dis, Nantes, France; [Lefebvre, Maeva] Nantes Univ, INSERM, Ctr Invest Clin 1413, Nantes, France; [Velikov, Petar; Kapincheva, Nikol] Med Univ Sofia, Infect Dis Hosp Prof Ivan Kirov, Sofia, Bulgaria; [Festou, Benjamin; Faucher, Jean-Francois] Ctr Hosp Univ Limoges, Dept Infect Dis & Trop Med, Limoges, France; [Faucher, Jean-Francois] INSERM U1094, Limoges, France; [Duvnjak, Mario; Svitek, Luka] Univ Hosp Ctr Osijek, Clin Infect Dis, Osijek, Croatia; [Duvnjak, Mario; Svitek, Luka] JJ Strossmayer Univ Osijek, Fac Med Osijek, Osijek, Croatia; [Afsar, Elcin] Atilim Univ, Vocat Sch Hlth Serv, Ankara, Turkiye; [Yarimoglu, Saliha; Yarimoglu, Rafet] Karaman Training & Res Hosp, Karaman, Turkiye; [Janssen, Cecile] Ctr Hosp Annecy Genevois, Infect Dis Unit, Annecy, France en_US
dc.description Beraud, Guillaume/0000-0002-4705-0916; Epaulard, Olivier/0000-0001-8282-9522; Civljak, Rok/0000-0001-8766-7438; Velikov, Petar/0000-0002-7436-4064; Yarimoglu, Saliha/0000-0001-7081-9474; Blanchi, Sophie/0009-0008-9323-5947; Svitek, Luka/0000-0003-0208-5821 en_US
dc.description.abstract Objectives: The emergence of SARS-CoV-2 variants raised questions about the extent to which vaccines designed in 2020 have remained effective. We aimed to assess whether vaccine status was associated with the severity of Omicron SARS-CoV-2 infection in hospitalized patients.Methods: We conducted an international, multi-centric, retrospective study in 14 centres (Bulgaria, Croatia, France, and Turkey). We collected data on patients hospitalized for >= 24 hours between 1 December 2021 and 3 March 2022 with PCR-confirmed infection at a time of exclusive Omicron circu-lation and hospitalization related or not related to the infection. Patients who had received prophylaxis by monoclonal antibodies were excluded. Patients were considered fully vaccinated if they had received at least two injections of either mRNA and/or ChAdOx1-S or one injection of Ad26.CoV2-S vaccines. Results: Among 1215 patients (median age, 73.0 years; interquartile range, 57.0-84.0; 51.3% men), 746 (61.4%) were fully vaccinated. In multivariate analysis, being vaccinated was associated with lower 28 -day mortality (Odds Ratio [95% Confidence Interval] (OR [95CI]) = 0.50 [0.32-0.77]), intensive care unit admission (OR [95CI] = 0.40 [0.26-0.62]), and oxygen requirement (OR [95CI] = 0.34 [0.25-0.46]), independent of age and comorbidities. When co-analysing these patients with Omicron infection with 948 patients with Delta infection from a study we recently conducted, Omicron infection was associated with lower 28-day mortality (OR [95CI] = 0.53 [0.37-0.76]), intensive care unit admission (OR [95CI] = 0.19 [0.12-0.28]), and oxygen requirements (OR [95CI] = 0.50 [0.38-0.67]), independent of age, comorbidities, and vaccination status.Discussion: Originally designed vaccines have remained effective on the severity of Omicron SARS-CoV-2 infection. Omicron is associated with a lower risk of severe forms, independent of vaccination and pa-tient characteristics. Guillaume Beraud, Clin Microbiol Infect 2023;29:642 (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/). en_US
dc.identifier.citationcount 4
dc.identifier.doi 10.1016/j.cmi.2022.12.020
dc.identifier.endpage 650 en_US
dc.identifier.issn 1198-743X
dc.identifier.issn 1469-0691
dc.identifier.issue 5 en_US
dc.identifier.pmid 36587737
dc.identifier.scopus 2-s2.0-85147890026
dc.identifier.scopusquality Q1
dc.identifier.startpage 642 en_US
dc.identifier.uri https://doi.org/10.1016/j.cmi.2022.12.020
dc.identifier.uri https://hdl.handle.net/20.500.14411/2529
dc.identifier.volume 29 en_US
dc.identifier.wos WOS:000986698700001
dc.identifier.wosquality Q1
dc.institutionauthor Tülek, Necla
dc.language.iso en en_US
dc.publisher Elsevier Sci Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 9
dc.subject Breakthrough infection en_US
dc.subject Omicron en_US
dc.subject SARS-CoV-2 en_US
dc.title Impact of Vaccination on the Presence and Severity of Symptoms in Hospitalized Patients With an Infection of the Omicron Variant (b.1.1.529) of the Sars-Cov (subvariant Ba.1) en_US
dc.type Article en_US
dc.wos.citedbyCount 8
dspace.entity.type Publication
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