Poly(ε-Caprolactone) Composites Containing Gentamicin-Loaded Β-Tricalcium Phosphate/Gelatin Microspheres as Bone Tissue Supports
| dc.contributor.author | Sezer, Umran Aydemir | |
| dc.contributor.author | Aksoy, Eda Ayse | |
| dc.contributor.author | Hasirci, Vasif | |
| dc.contributor.author | Hasirci, Nesrin | |
| dc.date.accessioned | 2024-07-05T14:28:48Z | |
| dc.date.available | 2024-07-05T14:28:48Z | |
| dc.date.issued | 2013 | |
| dc.description | Aksoy, Eda Ayse/0000-0003-4977-0412; Hasirci, Nesrin/0000-0002-4497-0194 | en_US |
| dc.description.abstract | In this work, novel antibacterial composites were prepared by using poly(epsilon-caprolactone) (PCL) as the main matrix material, and gentamicin-loaded microspheres composed of beta-tricalcium phosphate (beta-TCP) and gelatin. The purpose is to use this biodegradable material as a support for bone tissue. This composite system is expected to enhance bone regeneration by the presence of beta-TCP and prevent a possible infection that might occur around the defected bone region by the release of gentamicin. The effects of the ratio of the beta-TCP/gelatin microspheres on the morphological, mechanical, and degradation properties of composite films as well as in vitro antibiotic release and antibacterial activities against Escherichia coli and Staphylococcus aureus were investigated. The results showed that the composites of PCL and beta-TCP/gelatin microspheres had antibacterial activities for both bacteria. (C) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 | en_US |
| dc.description.sponsorship | [METU-BAP-07-02-2011-101] | en_US |
| dc.description.sponsorship | The authors gratefully acknowledge the support provided by Dr. Nusret Tahari and Osman Aytuzlar of the Middle East Technical University Medical Center during the microbiological analyses, METU Central Laboratory for SEM analysis, and Assoc. Prof. Caner Durucan for guidance during beta-TCP synthesis. This study was supported by a grant from METU-BAP-07-02-2011-101. | en_US |
| dc.identifier.doi | 10.1002/app.37770 | |
| dc.identifier.issn | 0021-8995 | |
| dc.identifier.issn | 1097-4628 | |
| dc.identifier.scopus | 2-s2.0-84868490088 | |
| dc.identifier.uri | https://doi.org/10.1002/app.37770 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14411/438 | |
| dc.language.iso | en | en_US |
| dc.publisher | Wiley | en_US |
| dc.relation.ispartof | Journal of Applied Polymer Science | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | poly(epsilon-caprolactone) | en_US |
| dc.subject | beta-tricalcium phosphate | en_US |
| dc.subject | gelatin | en_US |
| dc.subject | fillers | en_US |
| dc.subject | biodegradable | en_US |
| dc.subject | controlled release | en_US |
| dc.subject | antibacterial activity | en_US |
| dc.title | Poly(ε-Caprolactone) Composites Containing Gentamicin-Loaded Β-Tricalcium Phosphate/Gelatin Microspheres as Bone Tissue Supports | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Aksoy, Eda Ayse/0000-0003-4977-0412 | |
| gdc.author.id | Hasirci, Nesrin/0000-0002-4497-0194 | |
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| gdc.author.wosid | Aksoy, Eda Ayse/AAN-5519-2020 | |
| gdc.author.wosid | Hasirci, Vasif Nejat/N-5285-2018 | |
| gdc.author.wosid | Hasirci, Nesrin/I-4754-2018 | |
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| gdc.description.department | Atılım University | en_US |
| gdc.description.departmenttemp | [Sezer, Umran Aydemir; Aksoy, Eda Ayse; Hasirci, Vasif; Hasirci, Nesrin] Middle E Tech Univ, Ctr Excellence Biomat & Tissue Engn, BIOMATEN, TR-06800 Ankara, Turkey; [Sezer, Umran Aydemir; Hasirci, Vasif; Hasirci, Nesrin] Middle E Tech Univ, Grad Dept Biomed Engn, TR-06800 Ankara, Turkey; [Sezer, Umran Aydemir] Atilim Univ, Dept Chem Engn & Appl Chem, Fac Engn, TR-06836 Ankara, Turkey; [Aksoy, Eda Ayse] Middle E Tech Univ, Cent Lab, TR-06800 Ankara, Turkey; [Hasirci, Vasif] Middle E Tech Univ, Dept Biol Sci, Fac Arts & Sci, TR-06800 Ankara, Turkey; [Hasirci, Nesrin] Middle E Tech Univ, Dept Chem, Fac Arts & Sci, TR-06800 Ankara, Turkey | en_US |
| gdc.description.endpage | 2139 | en_US |
| gdc.description.issue | 3 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.startpage | 2132 | en_US |
| gdc.description.volume | 127 | en_US |
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| gdc.virtual.author | Aydemir, Ümran | |
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