Poly(ε-Caprolactone) Composites Containing Gentamicin-Loaded Β-Tricalcium Phosphate/Gelatin Microspheres as Bone Tissue Supports
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Date
2013
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Publisher
Wiley
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Abstract
In this work, novel antibacterial composites were prepared by using poly(epsilon-caprolactone) (PCL) as the main matrix material, and gentamicin-loaded microspheres composed of beta-tricalcium phosphate (beta-TCP) and gelatin. The purpose is to use this biodegradable material as a support for bone tissue. This composite system is expected to enhance bone regeneration by the presence of beta-TCP and prevent a possible infection that might occur around the defected bone region by the release of gentamicin. The effects of the ratio of the beta-TCP/gelatin microspheres on the morphological, mechanical, and degradation properties of composite films as well as in vitro antibiotic release and antibacterial activities against Escherichia coli and Staphylococcus aureus were investigated. The results showed that the composites of PCL and beta-TCP/gelatin microspheres had antibacterial activities for both bacteria. (C) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Description
Aksoy, Eda Ayse/0000-0003-4977-0412; Hasirci, Nesrin/0000-0002-4497-0194
Keywords
poly(epsilon-caprolactone), beta-tricalcium phosphate, gelatin, fillers, biodegradable, controlled release, antibacterial activity
Turkish CoHE Thesis Center URL
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Citation
15
WoS Q
Q2
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Source
Volume
127
Issue
3
Start Page
2132
End Page
2139