Evaluation of Dysfunctional High-Density Lipoprotein Levels With Myeloperoxidase/Paraoxonase-1 Ratio in Rheumatoid Arthritis

dc.authorid EREL, Ozcan/0000-0002-2996-3236
dc.authorid Alisik, Murat/0000-0003-0434-3206
dc.authorid Genc, Hakan/0000-0003-2573-4564
dc.authorid Alisik, Tugba/0000-0003-1856-9513
dc.authorid Alisik, Tugba/0000-0003-1856-9513
dc.authorid Ayhan, Fikriye Figen/0000-0001-6906-991X
dc.authorscopusid 57222552569
dc.authorscopusid 55552330200
dc.authorscopusid 6505973780
dc.authorscopusid 24922867400
dc.authorscopusid 7003861683
dc.authorscopusid 7003566828
dc.authorwosid EREL, Ozcan/U-1008-2019
dc.authorwosid Alisik, Murat/O-6114-2019
dc.authorwosid Genc, Hakan/CAA-4799-2022
dc.authorwosid Alisik, Tugba/ACB-3600-2022
dc.authorwosid Alisik, Tugba/IZQ-0487-2023
dc.authorwosid Ayhan, Fikriye Figen/O-4438-2014
dc.contributor.author Alisik, Tugba
dc.contributor.author Alisik, Murat
dc.contributor.author Nacir, Baris
dc.contributor.author Ayhan, Fikriye Figen
dc.contributor.author Genc, Hakan
dc.contributor.author Erel, Ozcan
dc.date.accessioned 2024-07-05T15:21:21Z
dc.date.available 2024-07-05T15:21:21Z
dc.date.issued 2021
dc.department Atılım University en_US
dc.department-temp [Alisik, Tugba] Abant Izzet Baysal Univ, Phys Med & Rehabil, Bolu, Turkey; [Alisik, Murat] Abant Izzet Baysal Univ, Med Biochem, Bolu, Turkey; [Nacir, Baris; Genc, Hakan] Ankara Numune Training & Res Hosp, Phys Med & Rehabil, Ankara, Turkey; [Ayhan, Fikriye Figen] Atilim Univ, Phys Med & Rehabil, Ankara, Turkey; [Erel, Ozcan] Yildirim Beyazit Univ, Med Biochem, Ankara, Turkey en_US
dc.description EREL, Ozcan/0000-0002-2996-3236; Alisik, Murat/0000-0003-0434-3206; Genc, Hakan/0000-0003-2573-4564; Alisik, Tugba/0000-0003-1856-9513; Alisik, Tugba/0000-0003-1856-9513; Ayhan, Fikriye Figen/0000-0001-6906-991X en_US
dc.description.abstract Background The aim of this study is to evaluate dysfunctional high-density lipoprotein cholesterol (HDL) by measuring myeloperoxidase (MPO)/paraoxonase 1 (PON1) ratio in patients with rheumatoid arthritis (RA) and to investigate the relationship between dysfunctional HDL and cardiovascular disease (CVD) in RA patients. Methods Sixty-seven healthy individuals and 130 RA patients were included in the study. Routine lipid panels (triglyceride (TG), low-density lipoprotein cholesterol (LDL), HDL, total cholesterol (TC), PON1 and MPO levels were measured. Disease activity scores-28 (DAS28) of RA patients were calculated. Cardiological examination records of the patients were assessed to detect patients who also have CVD. Results There were no significant differences between RA and control groups in routine lipid profiles (P > .05 for all). MPO/PON1 ratios were significantly elevated in the RA group compared with the control group (P < .001). MPO/PON1 ratios were higher in RA patients with CVD history compared with those without CVD (P < .05). MPO/PON1 ratios were correlated with DAS28 scores (rho: 0.357, P < .001). Conclusion HDL dysfunction determined by the MPO/PON1 ratio may be associated with the pathophysiology of increased CVD in RA. Thus, evaluating dysfunctional HDL levels by measuring the MPO/PON1 ratio in RA patients may allow more detailed patient follow-up, as well as the reduction of CVD events in RA patients with therapeutic agents aiming to increase the functional properties of HDL by decreasing this ratio. en_US
dc.identifier.citationcount 6
dc.identifier.doi 10.1111/ijcp.14172
dc.identifier.issn 1368-5031
dc.identifier.issn 1742-1241
dc.identifier.issue 7 en_US
dc.identifier.pmid 33756027
dc.identifier.scopus 2-s2.0-85103211952
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1111/ijcp.14172
dc.identifier.uri https://hdl.handle.net/20.500.14411/2067
dc.identifier.volume 75 en_US
dc.identifier.wos WOS:000634228800001
dc.identifier.wosquality Q3
dc.institutionauthor Ayhan, Fikriye Figen
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 9
dc.subject [No Keyword Available] en_US
dc.title Evaluation of Dysfunctional High-Density Lipoprotein Levels With Myeloperoxidase/Paraoxonase-1 Ratio in Rheumatoid Arthritis en_US
dc.type Article en_US
dc.wos.citedbyCount 8
dspace.entity.type Publication
relation.isAuthorOfPublication a89d8956-de26-456d-8404-49ddb4d417bf
relation.isAuthorOfPublication.latestForDiscovery a89d8956-de26-456d-8404-49ddb4d417bf

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