Quantification of the Effects of Transcutaneous Electrical Nerve Stimulation With Functional Magnetic Resonance Imaging: a Double-Blind Randomized Placebo-Controlled Study

dc.authorid Ozcelik, Erol/0000-0003-0370-8517
dc.authorid Gokcay, Didem/0000-0002-1101-0306
dc.authorscopusid 7006159444
dc.authorscopusid 7005706041
dc.authorscopusid 6603223092
dc.authorscopusid 26424777100
dc.authorscopusid 9243603000
dc.authorscopusid 36466376400
dc.authorscopusid 7003868980
dc.authorwosid TAN, FATMA AYSEN AKINCI/I-9210-2013
dc.authorwosid Ozcelik, Erol/AAD-4252-2019
dc.authorwosid Gokcay, Didem/AAT-4112-2020
dc.contributor.author Kara, Murat
dc.contributor.author Ozcakar, Levent
dc.contributor.author Gokcay, Didem
dc.contributor.author Ozcelik, Erol
dc.contributor.author Yorubulut, Mehmet
dc.contributor.author Guneri, Sinem
dc.contributor.author Cetin, Alp
dc.contributor.other Computer Engineering
dc.date.accessioned 2024-07-05T15:16:01Z
dc.date.available 2024-07-05T15:16:01Z
dc.date.issued 2010
dc.department Atılım University en_US
dc.department-temp [Kara, Murat; Ozcakar, Levent; Guneri, Sinem; Kaymak, Bayram; Akinci, Aysen; Cetin, Alp] Hacettepe Univ, Sch Med, Dept Phys Med & Rehabil, Ankara, Turkey; [Gokcay, Didem] Middle E Tech Univ, Inst Informat, TR-06531 Ankara, Turkey; [Ozcelik, Erol] Atilim Univ, Dept Comp Engn, Ankara, Turkey; [Yorubulut, Mehmet] Primer Imaging Ctr, Ankara, Turkey en_US
dc.description Ozcelik, Erol/0000-0003-0370-8517; Gokcay, Didem/0000-0002-1101-0306 en_US
dc.description.abstract Objective: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) by using functional magnetic resonance imaging (fMRI) in patients with carpal tunnel syndrome (CTS). Design: Randomized controlled trial. Settings: University medical center and an outpatient imaging center. Participants: Female patients with CTS (n=20) were randomized into 2 groups receiving either TENS (n=10) or sham TENS (n=10). In both groups, an initial baseline fMRI session was performed via stimulating digits 2, 5, and 3 in turn, I scan run for each. TENS versus sham TENS treatment was given, and a repeat imaging was performed starting 20 minutes after the treatment as follows: second finger on the 20th minute, fifth finger on the 25th minute (ulnar nerve innervated control finger), and third finger on the 30th min. Interventions: Not applicable. Main Outcome Measure: Differences in fMRI activation between the 2 groups were evaluated. Results: Our results demonstrated that 20 to 25 minutes after TENS treatment-but not in the sham TENS group-a significant fMRI signal decrease for digit 2 (post-TENS vs baseline) was observed in the secondary somatosensory regions, ipsilateral primary motor cortex (M1), contralateral supplementary motor cortex (SMA), contralateral parahippocampal gyrus, contralateral lingual gyrus, and bilateral superior temporal gyrus. Measurements on the 25th to 30th minutes for digit 5 were similar between the groups, with presence of activities in areas other than generally activated regions because of painful stimuli. Thirty to 35 minutes after TENS treatment, a significant fMRI signal decrease for digit 3 was detected in the contralateral M1 and contralateral SMA only in the TENS group. Conclusions: Our findings showed that TENS treatment significantly decreased the pain-related cortical activations caused by stimulation of the median nerve innervated fingers up to 35 minutes after treatment. en_US
dc.identifier.citationcount 21
dc.identifier.doi 10.1016/j.apmr.2010.04.023
dc.identifier.endpage 1165 en_US
dc.identifier.issn 0003-9993
dc.identifier.issn 1532-821X
dc.identifier.issue 8 en_US
dc.identifier.pmid 20684895
dc.identifier.scopus 2-s2.0-77955623495
dc.identifier.startpage 1160 en_US
dc.identifier.uri https://doi.org/10.1016/j.apmr.2010.04.023
dc.identifier.uri https://hdl.handle.net/20.500.14411/1578
dc.identifier.volume 91 en_US
dc.identifier.wos WOS:000281178900002
dc.identifier.wosquality Q1
dc.institutionauthor Özçelik, Erol
dc.language.iso en en_US
dc.publisher W B Saunders Co-elsevier inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 29
dc.subject Carpal tunnel syndrome en_US
dc.subject Magnetic resonance imaging en_US
dc.subject Rehabilitation en_US
dc.subject Transcutaneous electric nerve stimulation en_US
dc.title Quantification of the Effects of Transcutaneous Electrical Nerve Stimulation With Functional Magnetic Resonance Imaging: a Double-Blind Randomized Placebo-Controlled Study en_US
dc.type Article en_US
dc.wos.citedbyCount 20
dspace.entity.type Publication
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