Stimulus-Responsive Sequential Release Systems for Drug and Gene Delivery

dc.contributor.author Ahmadi, Sepideh
dc.contributor.author Rabiee, Navid
dc.contributor.author Bagherzadeh, Mojtaba
dc.contributor.author Elmi, Faranak
dc.contributor.author Fatahi, Yousef
dc.contributor.author Farjadian, Fatemeh
dc.contributor.author Hamblin, Michael R.
dc.date.accessioned 2024-07-05T15:39:38Z
dc.date.available 2024-07-05T15:39:38Z
dc.date.issued 2020
dc.description Fatahi, Yousef/0000-0003-0374-2141; Rabiee, Mohammad/0000-0003-1180-8729; Rabiee, Navid/0000-0002-6945-8541; Hamblin, Michael R/0000-0001-6431-4605; Karimi/0000-0002-7977-3940; ahmadi, sepideh/0000-0002-6178-1168; Nasseri, Behzad/0000-0003-3634-8327 en_US
dc.description.abstract In recent years, a range of studies have been conducted with the aim to design and characterize delivery systems that are able to release multiple therapeutic agents in controlled and programmed temporal sequences, or with spatial resolution inside the body. This sequential release occurs in response to different stimuli, including changes in pH, redox potential, enzyme activity, temperature gradients, light irradiation, and by applying external magnetic and electrical fields. Sequential release (SR)-based delivery systems, are often based on a range of different micro- or nanocarriers and may offer a silver bullet in the battle against various diseases, such as cancer. Their distinctive characteristic is the ability to release one or more drugs (or release drugs along with genes) in a controlled sequence at different times or at different sites. This approach can lengthen gene expression periods, reduce the side effects of drugs, enhance the efficacy of drugs, and induce an anti-proliferative effect on cancer cells due to the synergistic effects of genes and drugs. The key objective of this review is to summarize recent progress in SR-based drug/gene delivery systems for cancer and other diseases. (C) 2020 Elsevier Ltd. All rights reserved. en_US
dc.description.sponsorship US NIH [R01AI050875, R21AI121700] en_US
dc.description.sponsorship MRH was supported by US NIH Grants R01AI050875 and R21AI121700. en_US
dc.identifier.doi 10.1016/j.nantod.2020.100914
dc.identifier.issn 1748-0132
dc.identifier.issn 1878-044X
dc.identifier.scopus 2-s2.0-85087278714
dc.identifier.uri https://doi.org/10.1016/j.nantod.2020.100914
dc.identifier.uri https://hdl.handle.net/20.500.14411/3245
dc.language.iso en en_US
dc.publisher Elsevier Sci Ltd en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Sequential drug and gene release en_US
dc.subject Stimulus-responsive nanoparticles en_US
dc.subject Cancer nanomedicine en_US
dc.subject Temporal control en_US
dc.subject Synergistic combinations en_US
dc.title Stimulus-Responsive Sequential Release Systems for Drug and Gene Delivery en_US
dc.type Review en_US
dspace.entity.type Publication
gdc.author.id Fatahi, Yousef/0000-0003-0374-2141
gdc.author.id Rabiee, Mohammad/0000-0003-1180-8729
gdc.author.id Rabiee, Navid/0000-0002-6945-8541
gdc.author.id Hamblin, Michael R/0000-0001-6431-4605
gdc.author.id Karimi/0000-0002-7977-3940
gdc.author.id ahmadi, sepideh/0000-0002-6178-1168
gdc.author.id Nasseri, Behzad/0000-0003-3634-8327
gdc.author.scopusid 58189812000
gdc.author.scopusid 57201008317
gdc.author.scopusid 58070347200
gdc.author.scopusid 57217480243
gdc.author.scopusid 56560134100
gdc.author.scopusid 57205292283
gdc.author.scopusid 58948373100
gdc.author.wosid Hamblin, Mike/AAB-2511-2022
gdc.author.wosid Fatahi, Yousef/S-6193-2016
gdc.author.wosid Rabiee, Mohammad/L-9865-2018
gdc.author.wosid Rabiee, Navid/K-4407-2019
gdc.author.wosid Bagherzadeh, Mojtaba/AAE-6814-2020
gdc.author.wosid Baheiraei, Nafiseh/P-4999-2019
gdc.author.wosid Karimi/F-8405-2017
gdc.coar.access open access
gdc.coar.type text::review
gdc.description.department Atılım University en_US
gdc.description.departmenttemp [Ahmadi, Sepideh] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Cal Biotechnol, Student Res Comm, Tehran, Iran; [Ahmadi, Sepideh] Shahid Beheshti Univ Med Sci, Cellular & Mol Biol Res Ctr, Tehran, Iran; [Rabiee, Navid; Bagherzadeh, Mojtaba] Sharif Univ Technol, Dept Chem, Tehran, Iran; [Elmi, Faranak] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Biotechnol, Tabriz, Iran; [Elmi, Faranak] Islamic Azad Univ, Fac Sci, Dept Biol, Marand Branch, Marand, Iran; [Fatahi, Yousef] Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut Nanotechnol, Tehran, Iran; [Fatahi, Yousef] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran; [Fatahi, Yousef] Universal Sci Educ & Res Ctr USERN, Tehran, Iran; [Farjadian, Fatemeh] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Sch Pharm, Shiraz, Iran; [Baheiraei, Nafiseh] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol, Tissue Engn & Appl Cell Sci Div, Tehran, Iran; [Nasseri, Behzad] Hacettepe Univ, Bioengn Div, Chem Engn Dept, TR-06800 Ankara, Turkey; [Nasseri, Behzad] Hacettepe Univ, Bioengn Ctr, TR-06800 Ankara, Turkey; [Nasseri, Behzad] Atilim Univ, Chem Engn & Appl Chem Dept, TR-06830 Ankara, Turkey; [Rabiee, Mohammad] Amirkabir Univ Technol, Dept Biomed Engn, Biomat Grp, Tehran, Iran; [Dastjerd, Niloufar Tavakoli] Qazvin Univ Med Sci, Sch Allied Med Sci, Dept Med Biotechnol, Qazvin, Iran; [Valibeik, Ali] Lorestan Univ Med Sci, Sch Med, Dept Clin Biochem, Khorramabad, Iran; [Karimi, Mahdi] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran; [Karimi, Mahdi] Iran Univ Med Sci, Fac Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran; [Karimi, Mahdi] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran, Iran; [Karimi, Mahdi] Univ Tehran Med Sci, Res Ctr Sci & Technol Med, Tehran, Iran; [Karimi, Mahdi] Islamic Azad Univ, Appl Biotechnol Res Ctr, Tehran Med Sci, Tehran, Iran; [Karimi, Mahdi; Hamblin, Michael R.] Harvard Med Sch, Wellman Ctr Photomed, Massachusetts Gen Hosp, Boston, MA 02114 USA; [Hamblin, Michael R.] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein, South Africa en_US
gdc.description.publicationcategory Diğer en_US
gdc.description.scopusquality Q1
gdc.description.volume 34 en_US
gdc.description.wosquality Q1
gdc.identifier.pmid 32788923
gdc.identifier.wos WOS:000579498700005
gdc.scopus.citedcount 172
gdc.wos.citedcount 160

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