Preparation of Electrospun Pcl-Based Scaffolds by Mono/Multi-functionalized Go

dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorscopusid 57195473881
dc.authorscopusid 57220874244
dc.authorscopusid 16680382000
dc.contributor.author Basar, Ahmet Ozan
dc.contributor.author Sadhu, Veera
dc.contributor.author Sasmazel, Hilal Turkoglu
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T15:40:49Z
dc.date.available 2024-07-05T15:40:49Z
dc.date.issued 2019
dc.department Atılım University en_US
dc.department-temp [Basar, Ahmet Ozan; Sasmazel, Hilal Turkoglu] Atilim Univ, Dept Met & Mat Engn, TR-06836 Ankara, Turkey; [Sadhu, Veera] Banasthali Univ, Sch Phys Sci, PO Banasthali Vidyapith, Vanasthali 304022, Rajasthan, India en_US
dc.description Turkoglu Sasmazel, Hilal/0000-0002-0254-4541 en_US
dc.description.abstract In the present study, sythetic biodegradable polymer poly(epsilon-caprolactone) (PCL) and graphene oxide (GO) were combined together to prepare 3D, composite tissue scaffolds (PCL/GO scaffolds) by using electrospinning technique. Also, the influence of Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) and/or thiophene (Th) modified GO on the composite PCL/GO mats (PCL/GO, PCL/GO-GRGDSP, PCL/ GO-Th, PCL/GO-GRGDSP-Th) was further investigated. Characteristic examinations of the scaffolds were carried out by scanning electron microscope (SEM), contact angle (CA) measurements, x-ray photoelectron spectroscopy, TGA, electrical conductivity tests, phosphate buffer saline absorption and shrinkage tests and mechanical tests. All of the scaffolds were exhibited suitable bead free and uniform morphology according to SEM images. With the addition of GO, better hydrophilicity and a slight CA decrease (similar to 5 degrees) for the PCL/GO scaffolds were observed. Mechanical properties were reinforced drastically with the addition and well-dispersion of GO into PCL matrix. The incorporation of PCL and GO exhibited enhanced electrical conductivity and the highest value was found for PCL/GO-GRGDSP-Th (2%) as 15.06 mu S cm(-1). The MG-63 osteoblast cell culture studies (MTT assay, ALP activity, Alizarin-Red staining, fluorescence and SEM analyses) showed that PCL/GO-GRGDSP-Th (1%) scaffolds exhibited the highest biocompatibility performance (1.87 fold MTT absorbance value comparing with neat PCL) due to the advanced properties of GO and the biological interfaces. en_US
dc.identifier.citationcount 16
dc.identifier.doi 10.1088/1748-605X/ab2035
dc.identifier.issn 1748-6041
dc.identifier.issn 1748-605X
dc.identifier.issue 4 en_US
dc.identifier.pmid 31067511
dc.identifier.scopus 2-s2.0-85066969252
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1088/1748-605X/ab2035
dc.identifier.uri https://hdl.handle.net/20.500.14411/3370
dc.identifier.volume 14 en_US
dc.identifier.wos WOS:000469446400002
dc.identifier.wosquality Q2
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Iop Publishing Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 20
dc.subject poly(epsilon-caprolactone) en_US
dc.subject graphene oxide en_US
dc.subject Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) en_US
dc.subject thiophene (Th) en_US
dc.subject scaffold en_US
dc.subject osteoblast en_US
dc.title Preparation of Electrospun Pcl-Based Scaffolds by Mono/Multi-functionalized Go en_US
dc.type Article en_US
dc.wos.citedbyCount 21
dspace.entity.type Publication
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