Evaluation of Hepatosteatosis in Patients With Chronic Hepatitis B Virus Infection

dc.authorid Sayar, Merve Sefa/0000-0002-0436-4122
dc.authorid Acar, Ali/0000-0003-2008-5112
dc.authorscopusid 57222508487
dc.authorscopusid 57222439243
dc.authorscopusid 55777973900
dc.authorwosid Sayar, Merve Sefa/GVS-7640-2022
dc.authorwosid Erdim, Dilek/JAC-3222-2023
dc.contributor.author Sayar, Merve Sefa
dc.contributor.author Bulut, Dilek
dc.contributor.author Acar, Ali
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:25:08Z
dc.date.available 2024-07-05T15:25:08Z
dc.date.issued 2023
dc.department Atılım University en_US
dc.department-temp [Sayar, Merve Sefa; Bulut, Dilek] Van Training & Res Hosp, Infect Dis & Clin Microbiol, Van, Turkiye; [Sayar, Merve Sefa] Bursa Yuksek Ihtisas Training & Res Hosp, Infect Dis & Clin Microbiol, Bursa, Turkiye; [Bulut, Dilek] Diskapi Yildirim Beyazit Training & Res Hosp, Infect Dis & Clin Microbiol, Ankara, Turkiye; [Acar, Ali] Atilim Univ, Dept Microbiol, Fac Med, Ankara, Turkiye; [Sayar, Merve Sefa] Van Egitim & Arastirma Hastanesi, Blok 2 kat Hastaliklari Poliklinigi Edremit, Van, Turkiye en_US
dc.description Sayar, Merve Sefa/0000-0002-0436-4122; Acar, Ali/0000-0003-2008-5112 en_US
dc.description.abstract Background and study aims: The current study aimed to investigate the frequency of hepatic steatosis in chronic hepatitis B (CHB) patients and determine the possible risk factors associated with its presence.Patients and methods: This cross-sectional study retrospectively evaluated the medical records of 255 adult CHB patients visiting an infectious disease outpatient clinic. Patients with hepatitis B surface anti-gen positivity for >6 months and those who did not receive antiviral therapy were included in the study. The presence and stage of hepatic steatosis were determined through hepatobiliary ultrasonography.Results: The mean age of the patients was 40.6 +/- 12.7 years. Hepatic steatosis was detected in 44.4 % of the patients through ultrasound imaging. Our findings showed that the detected steatosis prevalence in our patients with CHB was significantly higher compared to the highest prevalence of non-alcoholic steatohepatitis found in the general Turkish population (19.9 %) [RR 2.23 (1.75-2.86), p < 0.001]. CHB patients with steatosis had significantly higher age, triglyceride, and gamma-glutamyl transferase levels than those without steatosis (p < 0.05). No significant association was found between the presence of steatosis, sex, liver function test results, and platelet, alkaline phosphatase, cholesterol, alpha fetoprotein, or HBV-DNA levels. No significant relationship was found between aspartate aminotransferase (AST)/platelet ratio index (APRI) and steatosis was examined (p > 0.05). Post-hoc analysis showed a sig-nificant relationship between HBV-DNA levels and ALT, AST, and APRI scores.Conclusion: Our data showed that hepatic steatosis is more common in CHB patients than in the general population. Older age and high triglyceride levels increased the risk of hepatic steatosis in CHB patients, consequently increasing GGT levels, which are indicative of liver damage, in these patients.(c) 2022 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved. en_US
dc.identifier.citationcount 2
dc.identifier.doi 10.1016/j.ajg.2022.05.002
dc.identifier.endpage 15 en_US
dc.identifier.issn 1687-1979
dc.identifier.issn 2090-2387
dc.identifier.issue 1 en_US
dc.identifier.pmid 35688683
dc.identifier.scopus 2-s2.0-85132346772
dc.identifier.scopusquality Q3
dc.identifier.startpage 11 en_US
dc.identifier.uri https://doi.org/10.1016/j.ajg.2022.05.002
dc.identifier.uri https://hdl.handle.net/20.500.14411/2511
dc.identifier.volume 24 en_US
dc.identifier.wos WOS:000953415500001
dc.identifier.wosquality Q4
dc.institutionauthor Acar, Ali
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 2
dc.subject APRI en_US
dc.subject Chronic hepatitis B en_US
dc.subject Fatty liver en_US
dc.subject Fibrosis en_US
dc.title Evaluation of Hepatosteatosis in Patients With Chronic Hepatitis B Virus Infection en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
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