Urinalysis of individuals with renal hyperfiltration using ATR-FTIR spectroscopy

dc.authoridKorkmaz, Filiz/0000-0003-3512-3521
dc.authoridSARIGUL, NESLIHAN/0000-0002-5371-7924
dc.authorscopusid12545162400
dc.authorscopusid56658622300
dc.authorscopusid57204017811
dc.authorscopusid8664101000
dc.authorwosidKorkmaz, Filiz/GOH-1457-2022
dc.authorwosidSARIGUL, NESLIHAN/J-1564-2013
dc.contributor.authorKurultak, Ilhan
dc.contributor.authorSarigul, Neslihan
dc.contributor.authorKodal, Nil Su
dc.contributor.authorKorkmaz, Filiz
dc.contributor.otherPhysics Group
dc.date.accessioned2024-07-05T15:24:13Z
dc.date.available2024-07-05T15:24:13Z
dc.date.issued2022
dc.departmentAtılım Universityen_US
dc.department-temp[Kurultak, Ilhan] Trakya Univ, Fac Med, Dept Nephrol, TR-22000 Edirne, Turkey; [Sarigul, Neslihan] Hacettepe Univ, Inst Nucl Sci, Ankara, Turkey; [Kodal, Nil Su] Trakya Univ, Fac Med, Dept Internal Med, Edirne, Turkey; [Korkmaz, Filiz] Atilim Univ, Fac Engn, Biophys Lab, Ankara, Turkeyen_US
dc.descriptionKorkmaz, Filiz/0000-0003-3512-3521; SARIGUL, NESLIHAN/0000-0002-5371-7924en_US
dc.description.abstractAbnormal increased glomerular filtration rate (GFR), otherwise known as renal hyperfiltration (RHf), is associated with an increased risk of chronic kidney disease and cardiovascular mortality. Although it is not considered as a disease alone in medicine today, early detection of RHf is essential to reducing risk in a timely manner. However, detecting RHf is a challenge since it does not have a practical biochemical marker that can be followed or quantified. In this study, we tested the ability of ATR-FTIR spectroscopy to distinguish 17 individuals with RHf (hyperfiltraters; RHf (+)), from 20 who have normal GFR (normofiltraters; RHf(-)), using urine samples. Spectra collected from hyperfiltraters were significantly different from the control group at positions 1621, 1390, 1346, 933 and 783/cm. Intensity changes at these positions could be followed directly from the absorbance spectra without the need for pre-processing. They were tentatively attributed to urea, citrate, creatinine, phosphate groups, and uric acid, respectively. Using principal component analysis (PCA), major peaks of the second derivative forms for the classification of two groups were determined. Peaks at 1540, 1492, 1390, 1200, 1000 and 840/cm were significantly different between the two groups. Statistical analysis showed that the spectra of normofiltraters are similar; however, those of hyperfiltraters show diversity at multiple positions that can be observed both from the absorbance spectra and the second derivative profiles. This observation implies that RHf can simultaneously affect the excretion of many substances, and that a spectroscopic analysis of urine can be used as a rapid and non-invasive pre-screening tool.en_US
dc.identifier.citation2
dc.identifier.doi10.1038/s41598-022-25535-1
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid36463336
dc.identifier.scopus2-s2.0-85143157080
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1038/s41598-022-25535-1
dc.identifier.urihttps://hdl.handle.net/20.500.14411/2409
dc.identifier.volume12en_US
dc.identifier.wosWOS:000969757300064
dc.identifier.wosqualityQ2
dc.institutionauthorKorkmaz Özkan, Filiz
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword Available]en_US
dc.titleUrinalysis of individuals with renal hyperfiltration using ATR-FTIR spectroscopyen_US
dc.typeArticleen_US
dspace.entity.typePublication
relation.isAuthorOfPublication1ebbd479-dfc4-411f-8702-e06ba4616da2
relation.isAuthorOfPublication.latestForDiscovery1ebbd479-dfc4-411f-8702-e06ba4616da2
relation.isOrgUnitOfPublication2682824b-512d-4a4e-8498-5b5719f606fe
relation.isOrgUnitOfPublication.latestForDiscovery2682824b-512d-4a4e-8498-5b5719f606fe

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