Comparison of Nat1, Nat2 & Gstt2-2 Activities in Normal and Neoplastic Human Breast Tissues

dc.authorid Isgor, belgin S/0000-0001-5716-3159
dc.authorscopusid 12239760700
dc.authorscopusid 57190741107
dc.authorscopusid 6603745283
dc.authorscopusid 6603125065
dc.authorscopusid 6603039843
dc.authorscopusid 57208659022
dc.authorscopusid 57195247877
dc.authorwosid ISGOR, Belgin/B-7829-2013
dc.authorwosid Guray, N.Tulin/AAZ-6727-2020
dc.contributor.author Geylan-SU, YS
dc.contributor.author Isgör, B
dc.contributor.author Coban, T
dc.contributor.author Kapucuoglu, N
dc.contributor.author Aydintug, S
dc.contributor.author Iscan, M
dc.contributor.author Güray, T
dc.contributor.other Chemical Engineering
dc.contributor.other Chemical Engineering
dc.date.accessioned 2024-10-06T10:57:32Z
dc.date.available 2024-10-06T10:57:32Z
dc.date.issued 2006
dc.department Atılım University en_US
dc.department-temp Middle E Tech Univ, Fac Arts & Sci, Dept Biol Sci, TR-06531 Ankara, Turkey; Atilim Univ, Fac Engn, Chem Grp, Ankara, Turkey; Ankara Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey; Oncol Hosp, Dept Pathol, Ankara, Turkey; Hacettepe Univ, Fac Med, Dept Gen Surg, TR-06100 Ankara, Turkey en_US
dc.description Isgor, belgin S/0000-0001-5716-3159 en_US
dc.description.abstract In this study, arylamine N-acetyltransferases, NATs (E.C.2.3.1.5) and glutathione-S-transferase-T2-2, GSTT2-2 (E.C.2.5.1.18) enzyme activities in the breast tumor and surrounding tumor-free tissues of 22 female breast cancer patients with infiltrating ductal carcinoma were measured. The possible impacts of grade of malignancy, chemotherapy treatment, estrogen receptor status and menopausal status on all enzyme activities were evaluated. The results showed that, both NAT2 and GSTT2-2 display significant differences between tumor and tumor-free breast tissues, while no difference was observed in NAT1. Grade of malignancy seems to be positively associated with NAT1 and negatively associated with GSTT2-2. Though, both NAT2 and GSTT2-2 have increased mean tumor activities, the grade of malignancy, chemotherapy status, menopausal status or estrogen receptor status are not correlated statistically. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 6
dc.identifier.endpage 78 en_US
dc.identifier.issn 0028-2685
dc.identifier.issn 1338-4317
dc.identifier.issue 1 en_US
dc.identifier.pmid 16416017
dc.identifier.scopus 2-s2.0-32144444515
dc.identifier.scopusquality Q3
dc.identifier.startpage 73 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14411/8740
dc.identifier.volume 53 en_US
dc.identifier.wos WOS:000235118800013
dc.identifier.wosquality Q3
dc.institutionauthor İşgör, Sultan Belgin
dc.institutionauthor İşgör, Sultan Belgin
dc.language.iso en en_US
dc.publisher Aepress Sro en_US
dc.relation.ispartof Neoplasma en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 7
dc.subject breast cancer en_US
dc.subject arylamine N-acetyltransferases en_US
dc.subject NAT1 en_US
dc.subject NAT2 en_US
dc.subject GSTT2-2 en_US
dc.title Comparison of Nat1, Nat2 & Gstt2-2 Activities in Normal and Neoplastic Human Breast Tissues en_US
dc.type Article en_US
dc.wos.citedbyCount 5
dspace.entity.type Publication
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relation.isOrgUnitOfPublication.latestForDiscovery bebae599-17cc-4f0b-997b-a4164a19b94b

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