The Effect of Sevoflurane and Fullerenol C 60 on the Liver and Kidney in Lower Extremity Ischemia-Reperfusion Injury in Mice With Streptozocin-Induced Diabetes

dc.authorid Küçük, Ayşegül/0000-0001-9316-9574
dc.authorid Sengel, Necmiye/0000-0001-8591-3658
dc.authorid Dursun, Ali Dogan/0000-0001-9056-0025
dc.authorid Ozdemir, Cagri/0000-0002-1266-8054
dc.authorid Arslan, Mustafa/0000-0003-4882-5063
dc.authorid Er, Fatma/0000-0003-3008-1764
dc.authorscopusid 57214248522
dc.authorscopusid 14627520900
dc.authorscopusid 57201724167
dc.authorscopusid 6601943232
dc.authorscopusid 56177530300
dc.authorscopusid 58310078200
dc.authorscopusid 6701424167
dc.authorwosid Küçük, Ayşegül/AFO-6819-2022
dc.authorwosid Sengel, Necmiye/KEH-6754-2024
dc.authorwosid Dursun, Ali Dogan/AAH-7617-2019
dc.authorwosid Ozdemir, Cagri/HTP-3022-2023
dc.contributor.author Sengel, Necmiye
dc.contributor.author Kucuk, Ayseguel
dc.contributor.author Ozdemir, Cagri
dc.contributor.author Sezen, Saban Cem
dc.contributor.author Kip, Gulay
dc.contributor.author Er, Fatma
dc.contributor.author Arslan, Mustafa
dc.date.accessioned 2024-07-05T15:25:29Z
dc.date.available 2024-07-05T15:25:29Z
dc.date.issued 2023
dc.department Atılım University en_US
dc.department-temp [Sengel, Necmiye] Gazi Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Ankara, Turkiye; [Kucuk, Ayseguel] Kutahya Hlth Sci Univ, Fac Med, Dept Physiol, Kutahya, Turkiye; [Ozdemir, Cagri] Mamak State Hosp, Dept Anesthesiol & Reanimat, Ankara, Turkiye; [Sezen, Saban Cem] Kirikkale Univ, Fac Med, Dept Histol & Embryol, Kirikkale, Turkiye; [Kip, Gulay; Arslan, Mustafa] Gazi Univ, Fac Med, Dept Anesthesiol & Reanimat, Ankara, Turkiye; [Er, Fatma; Kavutcu, Mustafa] Gazi Univ, Fac Med, Dept Med Biochem, Ankara, Turkiye; [Dursun, Ali Dogan] Atilim Univ, Fac Med, Dept Physiol, Ankara, Turkiye; [Polat, Yucel] Tekirdag Dr Ismail Fehmi Cumalioglu City Hosp, Cardiovasc Surg, Tekirdag, Turkiye; [Arslan, Mustafa] Gazi Univ, Life Sci Applicat & Res Ctr, Ankara, Turkiye; [Arslan, Mustafa] Gazi Univ, Lab Anima Breeding, Ankara, Turkiye; [Arslan, Mustafa] Gazi Univ, Expt Res Ctr GUDAM, Ankara, Turkiye; [Arslan, Mustafa] Gazi Univ, Fac Med, Dept Anesthesiol & Reanimat, TR-06510 Ankara, Turkiye en_US
dc.description Küçük, Ayşegül/0000-0001-9316-9574; Sengel, Necmiye/0000-0001-8591-3658; Dursun, Ali Dogan/0000-0001-9056-0025; Ozdemir, Cagri/0000-0002-1266-8054; Arslan, Mustafa/0000-0003-4882-5063; Er, Fatma/0000-0003-3008-1764 en_US
dc.description.abstract Objective: This study aimed to demonstrate whether fullerenol C60, sevoflurane anesthesia, or a combination of both had protective effects on the liver and kidneys in lower extremity ischemia-reperfusion injury (IRI) in mice with streptozocin-induced diabetes. Methods: A total of 46 Swiss albino mice were divided into six groups as follows: control group (group C, n=7), diabetes group (group D, n=7), diabetes-ischemia/reperfusion (group DIR, n=8), diabetes-ischemia/reperfusion-fullerenol C60 (group DIR-FC60, n=8), diabetes-ischemia/reperfusion-sevoflurane (group DIR-S, n=8), and the diabetes-ischemia/reperfusion-fullerenol C60-sevoflurane (group DIR-S-FC60, n=8). Fullerenol C60 (100mg/kg) was administered intraperitoneally 30 min before the ischemia-reperfusion procedure to the fullerenol groups (DIR-FC60 and DIR-S-FC60). In the DIR groups, 2 hours (h) ischemia-2h reperfusion periods were performed. In the sevoflurane groups, sevoflurane was applied during the ischemia-reperfusion period with 100% O2. Liver and kidney tissues were removed at the end of the reperfusion procedure for biochemical and histopathological examinations.Results: In liver tissue, hydropic degeneration, sinusoidal dilatation, pycnotic nuclei, prenecrotic cells, and mononuclear cell infiltration in parenchyma were significantly more frequent in group DIR than in groups D and group C. In terms of the histopathologic criteria examined, more positive results were seen in group DIR-FC60, and when group DIR-FC60 was compared with group DIR, the difference was significant. The best results in AST, ALT, glucose, TBARS levels, and SOD enzyme activities in liver tissue were in group DIR-FC60 compared with group DIR, followed by groups DIR-S-FC60 and DIR-S, respectively. Regarding TBARS levels and SOD enzyme activities in kidney tissue, the best results were in groups DIR-FC60, DIR-S-FC60, and DIR-S, respectively.Conclusion: According to our findings, it is clear that fullerenol C60 administered intraperitoneally 30 min before ischemia, alone or together with sevoflurane, reduces oxidative stress in distant organ damage caused by lower extremity IRI, and reduces liver and kidney tissue damage in histopathologic examinations. en_US
dc.description.sponsorship Gazi University BAP coordination unit [TCD- 2022-8210] en_US
dc.description.sponsorship This study was supported by the Gazi University BAP coordination unit within the scope of this project numbered TCD- 2022-8210. en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.2147/IJN.S432924
dc.identifier.endpage 7557 en_US
dc.identifier.issn 1178-2013
dc.identifier.pmid 38111848
dc.identifier.scopus 2-s2.0-85179692754
dc.identifier.startpage 7543 en_US
dc.identifier.uri https://doi.org/10.2147/IJN.S432924
dc.identifier.uri https://hdl.handle.net/20.500.14411/2546
dc.identifier.volume 18 en_US
dc.identifier.wos WOS:001125067900001
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Dove Medical Press Ltd en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 8
dc.subject lower extremity en_US
dc.subject ischemia-reperfusion en_US
dc.subject diabetes en_US
dc.subject fullerenol C60 en_US
dc.subject sevoflurane en_US
dc.subject kidney en_US
dc.subject liver en_US
dc.subject mice en_US
dc.title The Effect of Sevoflurane and Fullerenol C 60 on the Liver and Kidney in Lower Extremity Ischemia-Reperfusion Injury in Mice With Streptozocin-Induced Diabetes en_US
dc.type Article en_US
dc.wos.citedbyCount 8
dspace.entity.type Publication

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