Comparison of Hematopoietic and Spermatogonial Stem Cell Niches From the Regenerative Medicine Aspect

dc.authorid KORKUSUZ, PETEK/0000-0002-7553-3915
dc.authorid Onen, Selin/0000-0002-3255-3035
dc.authorid köse, sevil/0000-0003-2188-9534
dc.authorscopusid 56494407000
dc.authorscopusid 57191626691
dc.authorscopusid 57204933836
dc.authorscopusid 6602104436
dc.authorwosid KORKUSUZ, PETEK/JCD-9195-2023
dc.authorwosid Yersal, Nilgun/AAB-1958-2020
dc.authorwosid Yersal, Nilgun/JCD-4862-2023
dc.authorwosid Onen, Selin/IWU-4803-2023
dc.authorwosid köse, sevil/ABI-5227-2020
dc.authorwosid KORKUSUZ, PETEK/I-8321-2013
dc.contributor.author Kose, Sevil
dc.contributor.author Yersal, Nilgun
dc.contributor.author Onen, Selin
dc.contributor.author Korkusuz, Petek
dc.contributor.other Basic Sciences
dc.contributor.other Nutrition and Dietetics
dc.date.accessioned 2024-07-05T15:29:59Z
dc.date.available 2024-07-05T15:29:59Z
dc.date.issued 2018
dc.department Atılım University en_US
dc.department-temp [Kose, Sevil] Atilim Univ, Dept Nutr & Dietet, Fac Hlth Sci, Ankara, Turkey; [Yersal, Nilgun; Korkusuz, Petek] Hacettepe Univ, Dept Histol & Embryol, Fac Med, Ankara, Turkey; [Onen, Selin] Hacettepe Univ, Inst Hlth Sci, Dept Stem Cell Sci, Ankara, Turkey en_US
dc.description KORKUSUZ, PETEK/0000-0002-7553-3915; Onen, Selin/0000-0002-3255-3035; köse, sevil/0000-0003-2188-9534; en_US
dc.description.abstract Recent advances require a dual evaluation of germ and somatic stem cell niches with a regenerative medicine perspective. For a better point of view of the niche concept, it is needed to compare the microenvironments of those niches in respect to several components. The cellular environment of spermatogonial stem cells' niche consists of Sertoli cells, Leydig cells, vascular endothelial cells, epididymal fat cells, peritubular myoid cells while hematopoietic stem cells have mesenchymal stem cells, osteoblasts, osteoclasts, megacaryocytes, macrophages, vascular endothelial cells, pericytes and adipocytes in their microenvironment. Not only those cells', but also the effect of the other factors such as hormones, growth factors, chemokines, cytokines, extracellular matrix components, biomechanical forces (like shear stress, tension or compression) and physical environmental elements such as temperature, oxygen level and pH will be clarified during the chapter. Because it is known that the microenvironment has an important role in the stem cell homeostasis and disease conditions, it is crucial to understand the details of the microenvironment and to be able to compare the niche concepts of the different types of stem cells from each other, for the regenerative interventions. Indeed, the purpose of this chapter is to point out the usage of niche engineering within the further studies in the regenerative medicine field. Decellularized, synthetic or non-synthetic scaffolds may help to mimic the stem cell niche. However, the shared or different characteristics of germ and somatic stem cell microenvironments are necessary to constitute a proper niche model. When considered from this aspect, it is possible to produce some strategies on the personalized medicine by using those artificial models of stem cell microenvironment. en_US
dc.identifier.citationcount 12
dc.identifier.doi 10.1007/5584_2018_217
dc.identifier.endpage 40 en_US
dc.identifier.isbn 9783030041854
dc.identifier.issn 0065-2598
dc.identifier.issn 2214-8019
dc.identifier.pmid 29882209
dc.identifier.scopus 2-s2.0-85057999860
dc.identifier.startpage 15 en_US
dc.identifier.uri https://doi.org/10.1007/5584_2018_217
dc.identifier.uri https://hdl.handle.net/20.500.14411/2976
dc.identifier.volume 1107 en_US
dc.identifier.wos WOS:000458010000003
dc.institutionauthor Köse, Sevil
dc.institutionauthor Önen, Selin
dc.language.iso en en_US
dc.publisher Springer international Publishing Ag en_US
dc.relation.ispartofseries Advances in Experimental Medicine and Biology
dc.relation.publicationcategory Kitap Bölümü - Uluslararası en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 12
dc.subject Bone marrow niche en_US
dc.subject Hematopoietic stem cell en_US
dc.subject Microenvironment en_US
dc.subject Niche en_US
dc.subject Regeneration en_US
dc.subject Spermatogonial stem cell en_US
dc.title Comparison of Hematopoietic and Spermatogonial Stem Cell Niches From the Regenerative Medicine Aspect en_US
dc.type Book Part en_US
dc.wos.citedbyCount 13
dspace.entity.type Publication
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