Effect of Nutritional Support on Nutritional Status and Inflammation in Malnourished Patients Undergoing Maintenance Hemodialysis

dc.contributor.author Demirci, Bahar Gurlek
dc.contributor.author Carrero, Juan Jesus
dc.contributor.author Tutal, Emre
dc.contributor.author Bal, Zeynep
dc.contributor.author Sezer, Siren
dc.date.accessioned 2024-07-05T15:19:43Z
dc.date.available 2024-07-05T15:19:43Z
dc.date.issued 2021
dc.description sezer, siren/0000-0002-7326-8388; en_US
dc.description.abstract Introduction Protein energy wasting/malnutrition is a strong predictor of morbidity and mortality in patients on maintenance hemodialysis (MHD). We aimed to compare the effects of oral and/or intradialytic parenteral nutrition (IDPN) support on nutritional and inflammatory parameters in malnourished patients with MHD. Methods This is an observational study of 56 malnourished patients on MHD. We offered combined oral nutritional support (ONS) and IDPN for 12 months to all patients. Depending on patient choices for treatment, they were classified into four groups: group 1 (ONS only), group 2 (IDPN only), group 3 (both ONS and IDPN), and group 4 (patients who refused artificial nutrition support and only followed dietary advice). Normalized protein catabolic rate (nPCR), malnutrition inflammation score (MIS), and body composition (fat mass [FM], muscle mass [MM]) were assessed monthly. Findings The mean serum albumin levels of groups 2 and 3 significantly increased with the intervention, whereas that of group 4 significantly decreased. The mean nPCR levels of groups 2 and 3 significantly increased. Group 3 had the most significant positive change in serum albumin and nPCR levels. Mean serum C-reactive protein (CRP) levels of groups 1, 2, and 3 decreased, whereas those of group 4 increased. A increment in CRP was only identified in group 3. The MIS of groups 1, 2, and 3 significantly decreased whereas that of group 4 significantly increased. The increment % in FM was 1.1, 1.9, 9.1, and -2.9 for groups 1, 2, 3, and 4, respectively, and that in MM was -0.6, 4.4, 6.9, and -7.9 for groups 1, 2, 3, and 4, respectively. Discussion Compared to monotherapy or nutritional counseling, the choice of ONS plus IDPN is associated with improved nutritional status and decreased inflammation in malnourished patients on MHD. Nonetheless, interventional studies must be conducted to confirm these observations. en_US
dc.identifier.doi 10.1111/hdi.12936
dc.identifier.issn 1492-7535
dc.identifier.issn 1542-4758
dc.identifier.scopus 2-s2.0-85107995803
dc.identifier.uri https://doi.org/10.1111/hdi.12936
dc.identifier.uri https://hdl.handle.net/20.500.14411/2010
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject hemodialysis en_US
dc.subject malnutrition en_US
dc.title Effect of Nutritional Support on Nutritional Status and Inflammation in Malnourished Patients Undergoing Maintenance Hemodialysis en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.id sezer, siren/0000-0002-7326-8388
gdc.author.institutional Sezer, Siren
gdc.author.institutional Tutal, Emre
gdc.author.scopusid 55382803900
gdc.author.scopusid 16834646800
gdc.author.scopusid 55903409200
gdc.author.scopusid 55058022800
gdc.author.scopusid 7004935771
gdc.author.wosid Bal, Zeynep/AAZ-5795-2021
gdc.author.wosid sezer, siren/JYQ-2550-2024
gdc.author.wosid Akdoğan, Mehtap/IAO-2608-2023
gdc.coar.access metadata only access
gdc.coar.type text::journal::journal article
gdc.description.department Atılım University en_US
gdc.description.departmenttemp [Demirci, Bahar Gurlek] Ankara Yildirim Beyazit Univ, Fac Med, Dept Nephrol, Ankara, Turkey; [Carrero, Juan Jesus] Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden; [Tutal, Emre] Medicana Int Hosp, Dept Nephrol, Istanbul, Turkey; [Bal, Zeynep] Ankara Educ & Res Hosp, Dept Nephrol, Ankara, Turkey; [Sezer, Siren] Atilim Univ, Fac Med, Dept Nephrol, Ankara, Turkey en_US
gdc.description.endpage 540 en_US
gdc.description.issue 4 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q3
gdc.description.startpage 532 en_US
gdc.description.volume 25 en_US
gdc.description.wosquality Q4
gdc.identifier.pmid 34132475
gdc.identifier.wos WOS:000661796600001
gdc.scopus.citedcount 6
gdc.wos.citedcount 5
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relation.isAuthorOfPublication 29a32855-28a5-45c6-b28d-553cadba376d
relation.isAuthorOfPublication.latestForDiscovery 254017e3-7b63-4307-8f40-22a7243ff8ca

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