Long-Term Intermittent Caloric Restriction Remodels the Gut Microbiota in Mice Genetically Prone To Breast Cancer

dc.authorid Balcı, Tugce Nur/0000-0002-0569-2486
dc.authorid Kavruk, Murat/0000-0001-5331-7253
dc.authorid CETINER, OZLEM/0000-0001-9872-416X
dc.authorid Tuna, Bilge Guvenc/0000-0003-1348-1336
dc.authorscopusid 57904334300
dc.authorscopusid 7102693052
dc.authorscopusid 59269748000
dc.authorscopusid 24921796800
dc.authorscopusid 59270254200
dc.authorscopusid 57222153256
dc.authorscopusid 6504450287
dc.authorwosid Balcı, Tugce Nur/JRF-3390-2023
dc.authorwosid Kavruk, Murat/O-6694-2016
dc.authorwosid Tuna, Bilge Guvenc/O-2215-2014
dc.contributor.author Keles, Nazim Arda
dc.contributor.author Dogan, Soner
dc.contributor.author Dogan, Aysenur
dc.contributor.author Sudagidan, Mert
dc.contributor.author Balci, Tugce Nur
dc.contributor.author Cetiner, Ozlem
dc.contributor.author Tuna, Bilge Guvenc
dc.contributor.other Nutrition and Dietetics
dc.date.accessioned 2024-09-10T21:33:30Z
dc.date.available 2024-09-10T21:33:30Z
dc.date.issued 2024
dc.department Atılım University en_US
dc.department-temp [Keles, Nazim Arda; Dogan, Soner; Dogan, Aysenur] Yeditepe Univ, Sch Med, Dept Med Biol, Istanbul, Turkiye; [Sudagidan, Mert; Ozalp, Veli Cengiz] Atilim Univ, Sch Med, Dept Med Biol, Ankara, Turkiye; [Balci, Tugce Nur; Cetiner, Ozlem] Atilim Univ, Sch Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye; [Kavruk, Murat] Istanbul Aydin Univ, Sch Med, Dept Med Biol, Istanbul, Turkiye; [Tuna, Bilge Guvenc] Yeditepe Univ, Sch Med, Dept Biophys, Istanbul, Turkiye en_US
dc.description Balcı, Tugce Nur/0000-0002-0569-2486; Kavruk, Murat/0000-0001-5331-7253; CETINER, OZLEM/0000-0001-9872-416X; Tuna, Bilge Guvenc/0000-0003-1348-1336 en_US
dc.description.abstract Objectives: Gut microbiota dysbiosis is among the risk factors for breast cancer development, together with genetic background and dietary habits. However, caloric restriction has been shown to remodel the gut microbiota and slow tumor growth. Here, we investigated whether the gut microbiota mediates the preventive effects of long-term chronic or intermittent caloric restriction on breast cancer predisposition. Methods: 10-week-old transgenic breast cancer-prone mice were randomly assigned to dietary groups (ad libitum, chronic caloric restriction, and intermittent caloric restriction groups) and fed up to week 81. Stool samples were collected at weeks 10 (baseline), 17 (young), 49 (adult), and 81 (old). 16S rRNA gene sequencing was performed to identify the gut microbiota profile of the different groups. In order to investigate the breast cancer gut microbiota profile within genetically predisposed individuals regardless of diet, mammary tumor-bearing mice and mammary tumor-free but genetically prone mice were selected from the ad libitum group (n = 6). Results: Intermittent caloric restriction increased the microbial diversity of adult mice and modified age- related compositional changes. A total of 13 genera were differentially abundant over time. Pathogenic Mycoplasma was enriched in the re-feeding period of the old intermittent caloric restriction group compared with baseline. Furthermore, mammary tumor-free mice showed shared gut microbiota characteristics with mammary tumor-bearing mice, suggesting an early link between genetic predisposition, gut microbiota, and breast cancer development. Conclusions: Our study revealed the role of gut microbes in the preventive effects of caloric restriction against breast cancer development, implying the significance of diet and microbiome interplay. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. en_US
dc.description.sponsorship Scientific and Tech-nological Research Council of Turkiye (TUBITAK) en_US
dc.description.sponsorship The authors thank Dr. Margot P. Cleary (University of Minne-sota, MN, USA) for generously donating the breeding colony of the MMTV-TGF-a a transgenic mice. The authors thank both graduate and undergraduate students who helped with the daily feeding and handling of mice. The authors also thank Yeditepe University Animal Facility (Istanbul, Turkey) staff for taking care of the ani-mals. This work was partly supported by The Scientific and Tech-nological Research Council of Turkiye (TUBITAK) . en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.citationcount 0
dc.identifier.doi 10.1016/j.nut.2024.112525
dc.identifier.issn 0899-9007
dc.identifier.issn 1873-1244
dc.identifier.pmid 39168040
dc.identifier.scopus 2-s2.0-85201506246
dc.identifier.scopusquality Q1
dc.identifier.uri https://doi.org/10.1016/j.nut.2024.112525
dc.identifier.uri https://hdl.handle.net/20.500.14411/7289
dc.identifier.volume 126 en_US
dc.identifier.wos WOS:001299282600001
dc.identifier.wosquality Q2
dc.institutionauthor Balcı, Tuğçe Nur
dc.institutionauthor Çetiner, Özlem
dc.language.iso en en_US
dc.publisher Elsevier Science inc en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 1
dc.subject Intermittent fasting en_US
dc.subject Mammary tumor en_US
dc.subject Predisposition en_US
dc.subject Microbiome en_US
dc.subject Dietary intervention en_US
dc.subject Aging en_US
dc.title Long-Term Intermittent Caloric Restriction Remodels the Gut Microbiota in Mice Genetically Prone To Breast Cancer en_US
dc.type Article en_US
dc.wos.citedbyCount 1
dspace.entity.type Publication
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