Long-term intermittent caloric restriction remodels the gut microbiota in mice genetically prone to breast cancer

dc.authoridBalcı, Tugce Nur/0000-0002-0569-2486
dc.authoridKavruk, Murat/0000-0001-5331-7253
dc.authoridCETINER, OZLEM/0000-0001-9872-416X
dc.authoridTuna, Bilge Guvenc/0000-0003-1348-1336
dc.authorscopusid57904334300
dc.authorscopusid7102693052
dc.authorscopusid59269748000
dc.authorscopusid24921796800
dc.authorscopusid59270254200
dc.authorscopusid57222153256
dc.authorscopusid6504450287
dc.authorwosidBalcı, Tugce Nur/JRF-3390-2023
dc.authorwosidKavruk, Murat/O-6694-2016
dc.authorwosidTuna, Bilge Guvenc/O-2215-2014
dc.contributor.authorKeles, Nazim Arda
dc.contributor.authorDogan, Soner
dc.contributor.authorDogan, Aysenur
dc.contributor.authorSudagidan, Mert
dc.contributor.authorBalci, Tugce Nur
dc.contributor.authorCetiner, Ozlem
dc.contributor.authorTuna, Bilge Guvenc
dc.contributor.otherNutrition and Dietetics
dc.date.accessioned2024-09-10T21:33:30Z
dc.date.available2024-09-10T21:33:30Z
dc.date.issued2024
dc.departmentAtılım Universityen_US
dc.department-temp[Keles, Nazim Arda; Dogan, Soner; Dogan, Aysenur] Yeditepe Univ, Sch Med, Dept Med Biol, Istanbul, Turkiye; [Sudagidan, Mert; Ozalp, Veli Cengiz] Atilim Univ, Sch Med, Dept Med Biol, Ankara, Turkiye; [Balci, Tugce Nur; Cetiner, Ozlem] Atilim Univ, Sch Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye; [Kavruk, Murat] Istanbul Aydin Univ, Sch Med, Dept Med Biol, Istanbul, Turkiye; [Tuna, Bilge Guvenc] Yeditepe Univ, Sch Med, Dept Biophys, Istanbul, Turkiyeen_US
dc.descriptionBalcı, Tugce Nur/0000-0002-0569-2486; Kavruk, Murat/0000-0001-5331-7253; CETINER, OZLEM/0000-0001-9872-416X; Tuna, Bilge Guvenc/0000-0003-1348-1336en_US
dc.description.abstractObjectives: Gut microbiota dysbiosis is among the risk factors for breast cancer development, together with genetic background and dietary habits. However, caloric restriction has been shown to remodel the gut microbiota and slow tumor growth. Here, we investigated whether the gut microbiota mediates the preventive effects of long-term chronic or intermittent caloric restriction on breast cancer predisposition. Methods: 10-week-old transgenic breast cancer-prone mice were randomly assigned to dietary groups (ad libitum, chronic caloric restriction, and intermittent caloric restriction groups) and fed up to week 81. Stool samples were collected at weeks 10 (baseline), 17 (young), 49 (adult), and 81 (old). 16S rRNA gene sequencing was performed to identify the gut microbiota profile of the different groups. In order to investigate the breast cancer gut microbiota profile within genetically predisposed individuals regardless of diet, mammary tumor-bearing mice and mammary tumor-free but genetically prone mice were selected from the ad libitum group (n = 6). Results: Intermittent caloric restriction increased the microbial diversity of adult mice and modified age- related compositional changes. A total of 13 genera were differentially abundant over time. Pathogenic Mycoplasma was enriched in the re-feeding period of the old intermittent caloric restriction group compared with baseline. Furthermore, mammary tumor-free mice showed shared gut microbiota characteristics with mammary tumor-bearing mice, suggesting an early link between genetic predisposition, gut microbiota, and breast cancer development. Conclusions: Our study revealed the role of gut microbes in the preventive effects of caloric restriction against breast cancer development, implying the significance of diet and microbiome interplay. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.en_US
dc.description.sponsorshipScientific and Tech-nological Research Council of Turkiye (TUBITAK)en_US
dc.description.sponsorshipThe authors thank Dr. Margot P. Cleary (University of Minne-sota, MN, USA) for generously donating the breeding colony of the MMTV-TGF-a a transgenic mice. The authors thank both graduate and undergraduate students who helped with the daily feeding and handling of mice. The authors also thank Yeditepe University Animal Facility (Istanbul, Turkey) staff for taking care of the ani-mals. This work was partly supported by The Scientific and Tech-nological Research Council of Turkiye (TUBITAK) .en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.citation0
dc.identifier.doi10.1016/j.nut.2024.112525
dc.identifier.issn0899-9007
dc.identifier.issn1873-1244
dc.identifier.pmid39168040
dc.identifier.scopus2-s2.0-85201506246
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.nut.2024.112525
dc.identifier.urihttps://hdl.handle.net/20.500.14411/7289
dc.identifier.volume126en_US
dc.identifier.wosWOS:001299282600001
dc.identifier.wosqualityQ2
dc.institutionauthorBalcı, Tuğçe Nur
dc.institutionauthorÇetiner, Özlem
dc.language.isoenen_US
dc.publisherElsevier Science incen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntermittent fastingen_US
dc.subjectMammary tumoren_US
dc.subjectPredispositionen_US
dc.subjectMicrobiomeen_US
dc.subjectDietary interventionen_US
dc.subjectAgingen_US
dc.titleLong-term intermittent caloric restriction remodels the gut microbiota in mice genetically prone to breast canceren_US
dc.typeArticleen_US
dspace.entity.typePublication
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