Synthesis and characterization of antibacterial drug loaded β-tricalcium phosphate powders for bone engineering applications

The main fields of operation for Metallurgical and Materials Engineering are production of engineering materials, defining and improving their features, as well as developing new materials to meet the expectations at every aspect of life and the users from these aspects. Founded in 2004 and graduated its 10th-semester alumni in 2018, our Department also obtained MÜDEK accreditation in the latter year. Offering the opportunity to hold an internationally valid diploma through the accreditation in question, our Department has highly qualified and experienced Academic Staff. Many of the courses offered at our Department are supported with various practice sessions, and internship studies in summer. This way, we help our students become better-equipped engineers for their future professional lives. With the Cooperative Education curriculum that entered into effect in 2019, students may volunteer to work at contracted companies for a period of six months with no extensions to their period of study.

Abstract

Powders of beta-tricalcium phosphate [beta-TCP, beta-Ca-3(PO4)(2)] and composite powders of beta-TCP and polyvinyl alcohol (PVA) were synthesized by using wet precipitation methods. First, the conditions for the preparation of single phase beta-TCP have been delineated. In the co-precipitation procedure, calcium nitrate and diammonium hydrogen phosphate were used as calcium and phosphorous precursors, respectively. The pH of the system was varied in the range 7-11 by adding designed amounts of ammonia solution. The filtered cakes were desiccated at 80 degrees C and subsequently calcined at different temperatures in the range between 700-1100 degrees C. Later on, rifampicin form II was used to produce drug-loaded beta-TCP and PVA/beta-TCP powders. All the synthesized materials have been characterized from morphological (by scanning electron microscopy) and structural-chemical (by X-ray diffraction and Fourier transform infrared spectroscopy) point of view. The drug loading capacity of the selected pure beta-TCP powder has been assessed. The biological performance (cytocompatibility in fibroblast cell culture and antibacterial efficacy against Escherichia coli and Staphylococcus aureus) has been tested with promising results. Application perspectives of the designed drug-bioceramic-polymer blends are advanced and discussed. [GRAPHICS] .

Description

Stan, George E./0000-0003-0289-8988; Chirica, Maria-Iuliana/0000-0003-4698-9857; Gunduz, Oguzhan/0000-0002-4926-6489; Turkoglu Sasmazel, Hilal/0000-0002-0254-4541; Kilic, Osman/0000-0002-4560-5527; Gunduz, Oguzhan/0000-0002-9427-7574