Şaşmazel, Hilal Türkoğlu
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S.,Hilal Turkoglu
Sasmazel, Hilal Tuerkoglu
Sasmazel, Hilal Turkoglu
H. T. Şaşmazel
Turkoglu Sasmazel H.
Sasmazel,H.T.
Şaşmazel,H.T.
Hilal Türkoğlu, Şaşmazel
H., Sasmazel
Şasmazel H.
S., Hilal Turkoglu
Ş.,Hilal Türkoğlu
Ş., Hilal Türkoğlu
Turkoğlu Şaşmazel H.
Hilal Turkoglu, Sasmazel
H.T.Sasmazel
H.T.Şaşmazel
Sasmazel H.
Sasmazel, H. T.
Türkoglu, H
Turkoglu, Hilal
Sasmazel, H. Turkoglu
Sasmazel, Hilal T.
H. T. Sasmazel
Şaşmazel, Hilal Türkoğlu
H.,Şaşmazel
Şaşmazel H.
Sasmazel, H. Tuerkodlu
Türkoǧlu Şaşmazel,H.
Şaşmazel, Hilal
Sasmazel, Hilal Tuerkoglu
Sasmazel, Hilal Turkoglu
H. T. Şaşmazel
Turkoglu Sasmazel H.
Sasmazel,H.T.
Şaşmazel,H.T.
Hilal Türkoğlu, Şaşmazel
H., Sasmazel
Şasmazel H.
S., Hilal Turkoglu
Ş.,Hilal Türkoğlu
Ş., Hilal Türkoğlu
Turkoğlu Şaşmazel H.
Hilal Turkoglu, Sasmazel
H.T.Sasmazel
H.T.Şaşmazel
Sasmazel H.
Sasmazel, H. T.
Türkoglu, H
Turkoglu, Hilal
Sasmazel, H. Turkoglu
Sasmazel, Hilal T.
H. T. Sasmazel
Şaşmazel, Hilal Türkoğlu
H.,Şaşmazel
Şaşmazel H.
Sasmazel, H. Tuerkodlu
Türkoǧlu Şaşmazel,H.
Şaşmazel, Hilal
Job Title
Profesor Doktor
Email Address
hilal.sasmazel@atilim.edu.tr
Main Affiliation
Metallurgical and Materials Engineering
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
52
Articles
33
Citation Count
750
Supervised Theses
9
49 results
Scholarly Output Search Results
Now showing 1 - 10 of 49
Article Citation - WoS: 21Citation - Scopus: 20Preparation of Electrospun Pcl-Based Scaffolds by Mono/Multi-functionalized Go(Iop Publishing Ltd, 2019) Basar, Ahmet Ozan; Sadhu, Veera; Sasmazel, Hilal Turkoglu; Metallurgical and Materials EngineeringIn the present study, sythetic biodegradable polymer poly(epsilon-caprolactone) (PCL) and graphene oxide (GO) were combined together to prepare 3D, composite tissue scaffolds (PCL/GO scaffolds) by using electrospinning technique. Also, the influence of Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) and/or thiophene (Th) modified GO on the composite PCL/GO mats (PCL/GO, PCL/GO-GRGDSP, PCL/ GO-Th, PCL/GO-GRGDSP-Th) was further investigated. Characteristic examinations of the scaffolds were carried out by scanning electron microscope (SEM), contact angle (CA) measurements, x-ray photoelectron spectroscopy, TGA, electrical conductivity tests, phosphate buffer saline absorption and shrinkage tests and mechanical tests. All of the scaffolds were exhibited suitable bead free and uniform morphology according to SEM images. With the addition of GO, better hydrophilicity and a slight CA decrease (similar to 5 degrees) for the PCL/GO scaffolds were observed. Mechanical properties were reinforced drastically with the addition and well-dispersion of GO into PCL matrix. The incorporation of PCL and GO exhibited enhanced electrical conductivity and the highest value was found for PCL/GO-GRGDSP-Th (2%) as 15.06 mu S cm(-1). The MG-63 osteoblast cell culture studies (MTT assay, ALP activity, Alizarin-Red staining, fluorescence and SEM analyses) showed that PCL/GO-GRGDSP-Th (1%) scaffolds exhibited the highest biocompatibility performance (1.87 fold MTT absorbance value comparing with neat PCL) due to the advanced properties of GO and the biological interfaces.Article Citation - WoS: 12Citation - Scopus: 13Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization(Mdpi, 2021) Alazzawi, Marwa; Alsahib, Nabeel Kadim Abid; Sasmazel, Hilal Turkoglu; Metallurgical and Materials EngineeringGlycine (Gly), which is the simplest amino acid, induces the inflammation response and enhances bone mass density, and particularly its beta polymorph has superior mechanical and piezoelectric properties. Therefore, electrospinning of Gly with any polymer, including polyvinyl alcohol (PVA), has a great potential in biomedical applications, such as guided bone regeneration (GBR) application. However, their application is limited due to a fast degradation rate and undesirable mechanical and physical properties. Therefore, encapsulation of Gly and PVA fiber within a poly(epsilon-caprolactone) (PCL) shell provides a slower degradation rate and improves the mechanical, chemical, and physical properties. A membrane intended for GBR application is a barrier membrane used to guide alveolar bone regeneration by preventing fast-proliferating cells from growing into the bone defect site. In the present work, a core/shell nanofibrous membrane, composed of PCL as shell and PVA:Gly as core, was developed utilizing the coaxial electrospinning technique and characterized morphologically, mechanically, physically, chemically, and thermally. Moreover, the characterization results of the core/shell membrane were compared to monolithic electrospun PCL, PVA, and PVA:Gly fibrous membranes. The results showed that the core-shell membrane appears to be a good candidate for GBR application with a nano-scale fiber of 412 +/- 82 nm and microscale pore size of 6.803 +/- 0.035 mu m. Moreover, the wettability of 47.4 +/- 2.2 degrees contact angle (C.A) and mechanical properties of 135 +/- 3.05 MPa average modulus of elasticity, 4.57 +/- 0.04 MPa average ultimate tensile stress (UTS), and 39.43% +/- 0.58% average elongation at break are desirable and suitable for GBR application. Furthermore, the X-ray diffraction (XRD) and transmission electron microscopy (TEM) results exhibited the formation of beta-Gly.Article Citation - WoS: 36Citation - Scopus: 40A Novel Treatment Strategy for Preterm Birth: Intra-Vaginal Progesterone-Loaded Fibrous Patches(Elsevier, 2020) Cam, Muhammet Emin; Hazar-Yavuz, Ayse Nur; Cesur, Sumeyye; Ozkan, Ozan; Alenezi, Hussain; Sasmazel, Hilal Turkoglu; Edirisinghe, Mohan; Metallurgical and Materials EngineeringProgesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for infra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.Article Citation - WoS: 5Citation - Scopus: 5A Drug-Eluting Nanofibrous Hyaluronic Acid-Keratin Mat for Diabetic Wound Dressing(Springernature, 2022) Su, Sena; Bedir, Tuba; Kalkandelen, Cevriye; Sasmazel, Hilal Turkoglu; Basar, Ahmet Ozan; Chen, Jing; Gunduz, Oguzhan; Metallurgical and Materials EngineeringDiabetes mellitus is a chronic metabolic disease associated with long-term multisystem complications, among which are non-healing diabetic foot ulcers (DFUs). Electrospinning is a sophisticated technique for the preparation of polymeric nanofibers impregnated with drugs for wound healing, burns, and diabetic ulcers. This study describes the fabrication and characterization of a novel drug-eluting dressing made of core-shell structured hyaluronic acid (HA)-keratin (KR)-polyethylene oxide (PEO) and polycaprolactone (PCL) nanofibers to treat diabetic wounds. The core-shell nanofibers produced by the emulsion electrospinning technique provide loading of metformin hydrochloride (MH), HA, and KR in the core of nanofibers, which in return improves the sustained long term release of the drug and prolongs the bioactivity. Morphological and chemical properties of the fibers were examined by SEM, FTIR, and XRD studies. It was observed that the fibers which contain HA and KR showed thin fiber structure, greater swelling capacity, fast degradation and increased cumulative drug release amount than neat emulsion fibers due to the hydrophilic nature of HA and KR. MH showed a sustained release from all fiber samples over 20 days and followed the first-order and Higuchi model kinetics and Fickian diffusion mechanism according to kinetic analysis results. In vitro cell culture studies showed that the developed mats exhibited enhanced biocompatibility performance with HA and KR incorporation. The results show that HA and KR-based emulsion electrospun fiber mats are potentially useful new nanofiber-based biomaterials in their use as drug carriers to treat diabetic wounds.Article Citation - WoS: 0Citation - Scopus: 1Surface Patterning of Poly(ε-Caprolactone) Scaffolds by Electrospinning for Monitoring Cell Biomass Behavior(Springer, 2022) Albayrak, Deniz; Sasmazel, Hilal Turkoglu; Metallurgical and Materials EngineeringThe aim of this work was to produce three-dimensional fibrous surface patterns of poly(epsilon-caprolactone) (PCL), onto two-dimensional smooth solvent cast PCL surfaces with an electrospinning method by using a mask/stencil for monitoring cell biomass behavior. The characterizations of produced scaffolds were done by thickness measurements, scanning electron microscopy (SEM) analyses, contact angle (CA) measurements, Fourier-transform infrared spectroscopy (FTIR), and mechanical tests. According to SEM micrographs, all of the electrospun scaffold surfaces exhibited bead-free and uniform morphology while solvent cast surfaces were smooth and nonporous. CA measurements revealed that the solvent cast surfaces had moderate hydrophilicity (similar to 60 degrees) while electrospun regions had a more hydrophobic character (similar to 110 degrees for fully electrospun surfaces and similar to 85 degrees for electrospun patterns). Mechanical testing showed the produced scaffolds had a brittle character. Moreover, cell culture studies were performed with mouse fibroblast (L929) cells for 7 days period, and cell attachment assay, MTT assay, fluorescence, and SEM analyses were done. Cell culture studies indicated that the solvent cast and electrospun patterns have different characteristics for cell behavior. Thus, cell movement, attachment, and proliferation can be directed and monitored by obtaining different surface topographies in a single substrate surface. Based on the results of this study, it was found that patterns consisting of polymeric nanofiber structures can also be created directly by the electrospinning method.Article Citation - WoS: 17Citation - Scopus: 19Mechanical and Biological Properties of Al2o3< and Tio2 Co-Doped Zirconia Ceramics(Elsevier Sci Ltd, 2017) Agac, Ozlem; Gozutok, Melike; Sasmazel, Hilal Turkoglu; Ozturk, Abdullah; Park, Jongee; Metallurgical and Materials EngineeringVarious amounts (ranging from 0 to 2 wt%) of TiO2 and Al2O3 were mono and co-doped to tetragonal zirconia ceramic containing 3 mol% yttria (3Y-TZP) by mechanical ball milling. Powders were compacted by uniaxial pressing at a pressure of 23 MPa. The compacts were pressureless sintered at 1450 degrees C for 2 h. Density, hardness, fracture toughness, and cell attachment of the co-doped 3Y-TZP ceramics were measured with respect to dopant addition to determine the effects of the kind and amount of dopants on the properties. The results show that density decreased gradually as the amount of dopant was increased. The mechanical properties showed the maximum value when 0.5 wt% TiO2 and 1.0 wt% Al2O3 were co-doped to 3Y-TZP. Crystalline phase formation and microstructural morphology were investigated by XRD and SEM analyses to explain the variations in the properties. Co-doping of TiO2 and Al2O3 to 3Y-TZP did not have an influence on the phases present, but decreased the grain size. The co-doping also affected the cell attachment and the growth on the surface of the zirconia ceramics.Master Thesis Eşeksenli Elektroeğrilmiş Çekirdek-kabuk Tipi Kompozit Pcl Kitosan Yara İyileşme Malzemeleri(2016) Sürücü, Seda; Şaşmazel, Hilal Türkoğlu; Metallurgical and Materials EngineeringBu çalışma, sentetik poly(ε-caprolactone) (PCL) ve doğal kitosan polimerlerinin doku mühendisliği uygulamaları için 3 boyutlu PCL/kitosan/PCL çekirdek-kabuk yapıları oluşturmak üzere bir araya getirilmesi ile ilgilidir. Doku iskeleleri elektroeğirme yöntemi ile üretilmiştir. Numunelerin karakterizasyon özellikleri temas açısı ölçümü (CA), Taramalı Elektron Mikroskopu (SEM), Transmisyon Elektron Mikroskopu (TEM), X-ışını Fotoelektron Spektrometresi (XPS) analizleri ile belirlenmiş ve ayrıca doku iskeleleri için gaz geçirgenlik testi, kalınlık ölçümleri, PBS emme ve büzüşme testleri yapılmıştır. Ortalama fiberler arası çap değerleri PCL için 0.717±0.198 µm, kitosan için 0.660±0.070 µm ve PCL/kitosan çekirdek-kabuk yapısı için 0.412±0.339 µm olarak hesaplanmıştır. Ayrıca ortalama gözenek boyutları PCL/kitosan çekirdek-kabuk yapısına kıyasla sırasıyla PCL için %66.91 ve kitosan için %61.90 kadar düşüş göstermiştir. PCL/kitosan çekirdek-kabuk yapısının XPS analizi PCL ve kitosan polimerlerinin karakteristik tepe değerlerini göstermiştir. Hücre kültürü çalışması L929 ATCC CCL-1 fare deri hücre hattı ile yürütülmüştür. Doku iskelelerinin biyouyumluluk performansı MTT tahlili, floresan mikrosbu, Lazer Taramalı Konfokal Mikroskobu (CLSM) analizleri ile saptanmıştır. Sonuçlar göstermiştir ki bu araştırmadaki üretilen mikro/nano lifli PCL/kitosan çekirdek-kabuk doku iskelelerinin üzerinde ve içine doğru hücre canlılığı ve yayılması artmıştır.Article Citation - WoS: 115Citation - Scopus: 120Novel Poly(ε-caprolactone)/Gelatin Wound Dressings Prepared by Emulsion Electrospinning With Controlled Release Capacity of Ketoprofen Anti-Inflammatory Drug(Elsevier, 2017) Basar, A. O.; Castro, S.; Torres-Giner, S.; Lagaron, J. M.; Sasmazel, H. Turkoglu; Metallurgical and Materials EngineeringIn the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared by solution electrospinning of poly(e-caprolactone) (PCL) with Ketoprofen at a weight ratio of 5 wt%. This Ketoprofen-containing PCL solution was also used as the oil phase in a 7:3 (wt/wt) emulsion with gelatin dissolved in acidified water. The resultant stable oil-in-water (O/W) emulsion of PCL-in-gelatin, also containing Ketoprofen at 5 wt%, was electrospun to produce the binary mat. Cross-linking process was performed by means of glutaraldehyde vapor on the electrospun binary mat to prevent dissolution of the hydrophilic gelatin phase. The performed characterization indicated that Ketoprofen was successfully embedded in the single and binary electrospun mats, i.e. PCL and PCL/gelatin, and both mats showed high hydrophobicity but poor thermal resistance. In vitro release studies interestingly revealed that, in comparison to the single PCL electrospun mat, the binary PCL/gelatin mat significantly hindered Ketoprofen burst release and exhibited a sustained release capacity of the drug for up to 4 days. In addition, the electrospun Ketoprofen-loaded mats showed enhanced attachment and proliferation of L929 mouse fibroblast cells, presenting the binary mat the highest cell growth yield due to its improved porosity. The here-developed electrospun materials clearly show a great deal of potential as novel wound dressings with an outstanding controlled capacity to release drugs.Article Citation - WoS: 26Citation - Scopus: 32Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering(Elsevier, 2021) Topsakal, Aysenur; Midha, Swati; Yuca, Esra; Tukay, Ari; Sasmazel, Hilal Turkoglu; Kalaskar, Deepak M.; Gunduz, Oguzhan; Metallurgical and Materials EngineeringOver the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.Article Citation - WoS: 10Development of Antibacterial Composite Electrospun Chitosan-Coated Polypropylene Materials(Amer Scientific Publishers, 2018) Gozutok, Melike; Basar, Ahmet Ozan; Sasmazel, Hilal Turkoglu; Metallurgical and Materials EngineeringIn this study, a natural antibacterial substance chitosan was coated with/without potassium sorbate (KS) (0.8% (w/w) of KS, 8% (w/v) chitosan) onto the polypropylene (PP) film by using electrospinning technique to obtain novel antibacterial composite materials for various applications such as wound dressing, tissue engineering, drug delivery and food packaging. Atmospheric pressure plasma surface treatment was applied onto polypropylene films in order to increase its wettability thus enhancing the adhesion capacity of the films and the optimum CA value was determined as 42.75 +/- 0.80 degrees. Scanning Electron Microscope (SEM) and X-ray Photoelectron Spectroscopy (XPS) analyses were realized to observe the morphological changes and chemical properties of the samples, respectively. Contact angle measurements, tensile testing, oxygen and water vapor transmission rate analyses were performed to obtain wettability values, mechanical properties and WVTRs, respectively. The WVTR was increased by plasma treatment and addition of KS (from 14.264 +/- 0.214% to 21.020 +/- 0.659%). The desired antibacterial performance of the samples was assessed with Staphylococcus aureus and Escherichia coli by inhibition ratio calculation and disc diffusion assay. The highest inhibition ratios were found as 64% for S. aureus and 92% for E. coli for plasma-treated CS-KS-PP films.
