Şaşmazel, Hilal Türkoğlu
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H. T. Şaşmazel
Turkoglu Sasmazel H.
Sasmazel,H.T.
Şaşmazel,H.T.
Hilal Türkoğlu, Şaşmazel
H., Sasmazel
Şasmazel H.
S., Hilal Turkoglu
Ş.,Hilal Türkoğlu
Ş., Hilal Türkoğlu
Turkoğlu Şaşmazel H.
Hilal Turkoglu, Sasmazel
H.T.Sasmazel
H.T.Şaşmazel
Sasmazel H.
Sasmazel, H. T.
Türkoglu, H
Turkoglu, Hilal
Sasmazel, H. Turkoglu
Sasmazel, Hilal T.
H. T. Sasmazel
Şaşmazel, Hilal Türkoğlu
H.,Şaşmazel
Şaşmazel H.
Sasmazel, H. Tuerkodlu
Türkoǧlu Şaşmazel,H.
Şaşmazel, Hilal
Sasmazel, Hilal Tuerkoglu
Sasmazel, Hilal Turkoglu
H. T. Şaşmazel
Turkoglu Sasmazel H.
Sasmazel,H.T.
Şaşmazel,H.T.
Hilal Türkoğlu, Şaşmazel
H., Sasmazel
Şasmazel H.
S., Hilal Turkoglu
Ş.,Hilal Türkoğlu
Ş., Hilal Türkoğlu
Turkoğlu Şaşmazel H.
Hilal Turkoglu, Sasmazel
H.T.Sasmazel
H.T.Şaşmazel
Sasmazel H.
Sasmazel, H. T.
Türkoglu, H
Turkoglu, Hilal
Sasmazel, H. Turkoglu
Sasmazel, Hilal T.
H. T. Sasmazel
Şaşmazel, Hilal Türkoğlu
H.,Şaşmazel
Şaşmazel H.
Sasmazel, H. Tuerkodlu
Türkoǧlu Şaşmazel,H.
Şaşmazel, Hilal
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hilal.sasmazel@atilim.edu.tr
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Metallurgical and Materials Engineering
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Sustainable Development Goals
2
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0
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11
SUSTAINABLE CITIES AND COMMUNITIES
0
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14
LIFE BELOW WATER
1
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6
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1
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1
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5
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9
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16
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17
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15
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10
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7
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8
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4
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12
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0
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3
GOOD HEALTH AND WELL-BEING
27
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13
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0
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45
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1385
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20
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50
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1273
Scholarly Output
55
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38
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211/1045
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WoS Citation Count
965
Scopus Citation Count
1019
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18
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18
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WoS Citations per Publication
17.55
Scopus Citations per Publication
18.53
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11
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| Journal | Count |
|---|---|
| Journal of Nanoscience and Nanotechnology | 4 |
| Bio-Medical Materials and Engineering | 3 |
| International Journal of Biological Macromolecules | 2 |
| Molecules | 2 |
| Nanomaterials | 2 |
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Book Part Citation - Scopus: 1Materials and Processes for Treatment of Microbiological Pollution in Water(Springer, 2021) Alazzawi,M.; Turkoglu Sasmazel,H.Clean and safe water is vital for the life and health of human beings. However, there are still millions of people around the world with inadequate clean water sources. Microbiological pollution is one of the most concerned water pollutants and is the crucial cause of waterborne diseases like diarrhea, resulting in about two million deaths annually due to severe dehydration (WHO in Guidelines for drinking-water quality. Incorporating the first addendum, WHO, Geneva, 2017). It is critical to develop methods using advanced materials and process to mitigate contaminants from water resources. Production of safe water usually involves disinfection and decontamination processes. Conventional disinfection process, such as chlorination, is challenged by the formation of disinfection by-products. Furthermore, the presence of emerging pathogenic, that resist conventional water treatment techniques, raised the crucial necessity for emerging materials and techniques for treating water from microbiological pollution (Shannon et al. in Nature 452:301–310, 2008). This chapter describes bacterial, viral, and protozoal microbiological pollution in water supplies and the application of emerging materials and techniques to eliminate such contaminations. © 2021, Springer Nature Switzerland AG.Article Citation - WoS: 39Citation - Scopus: 44A Novel Treatment Strategy for Preterm Birth: Intra-Vaginal Progesterone-Loaded Fibrous Patches(Elsevier, 2020) Cam, Muhammet Emin; Hazar-Yavuz, Ayse Nur; Cesur, Sumeyye; Ozkan, Ozan; Alenezi, Hussain; Sasmazel, Hilal Turkoglu; Edirisinghe, MohanProgesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for infra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.Article Citation - WoS: 6Citation - Scopus: 6A Drug-Eluting Nanofibrous Hyaluronic Acid-Keratin Mat for Diabetic Wound Dressing(Springernature, 2022) Su, Sena; Bedir, Tuba; Kalkandelen, Cevriye; Sasmazel, Hilal Turkoglu; Basar, Ahmet Ozan; Chen, Jing; Gunduz, OguzhanDiabetes mellitus is a chronic metabolic disease associated with long-term multisystem complications, among which are non-healing diabetic foot ulcers (DFUs). Electrospinning is a sophisticated technique for the preparation of polymeric nanofibers impregnated with drugs for wound healing, burns, and diabetic ulcers. This study describes the fabrication and characterization of a novel drug-eluting dressing made of core-shell structured hyaluronic acid (HA)-keratin (KR)-polyethylene oxide (PEO) and polycaprolactone (PCL) nanofibers to treat diabetic wounds. The core-shell nanofibers produced by the emulsion electrospinning technique provide loading of metformin hydrochloride (MH), HA, and KR in the core of nanofibers, which in return improves the sustained long term release of the drug and prolongs the bioactivity. Morphological and chemical properties of the fibers were examined by SEM, FTIR, and XRD studies. It was observed that the fibers which contain HA and KR showed thin fiber structure, greater swelling capacity, fast degradation and increased cumulative drug release amount than neat emulsion fibers due to the hydrophilic nature of HA and KR. MH showed a sustained release from all fiber samples over 20 days and followed the first-order and Higuchi model kinetics and Fickian diffusion mechanism according to kinetic analysis results. In vitro cell culture studies showed that the developed mats exhibited enhanced biocompatibility performance with HA and KR incorporation. The results show that HA and KR-based emulsion electrospun fiber mats are potentially useful new nanofiber-based biomaterials in their use as drug carriers to treat diabetic wounds.Master Thesis Eşeksenli Elektroeğrilmiş Çekirdek-kabuk Tipi Kompozit Pcl Kitosan Yara İyileşme Malzemeleri(2016) Sürücü, Seda; Şaşmazel, Hilal TürkoğluBu çalışma, sentetik poly(ε-caprolactone) (PCL) ve doğal kitosan polimerlerinin doku mühendisliği uygulamaları için 3 boyutlu PCL/kitosan/PCL çekirdek-kabuk yapıları oluşturmak üzere bir araya getirilmesi ile ilgilidir. Doku iskeleleri elektroeğirme yöntemi ile üretilmiştir. Numunelerin karakterizasyon özellikleri temas açısı ölçümü (CA), Taramalı Elektron Mikroskopu (SEM), Transmisyon Elektron Mikroskopu (TEM), X-ışını Fotoelektron Spektrometresi (XPS) analizleri ile belirlenmiş ve ayrıca doku iskeleleri için gaz geçirgenlik testi, kalınlık ölçümleri, PBS emme ve büzüşme testleri yapılmıştır. Ortalama fiberler arası çap değerleri PCL için 0.717±0.198 µm, kitosan için 0.660±0.070 µm ve PCL/kitosan çekirdek-kabuk yapısı için 0.412±0.339 µm olarak hesaplanmıştır. Ayrıca ortalama gözenek boyutları PCL/kitosan çekirdek-kabuk yapısına kıyasla sırasıyla PCL için %66.91 ve kitosan için %61.90 kadar düşüş göstermiştir. PCL/kitosan çekirdek-kabuk yapısının XPS analizi PCL ve kitosan polimerlerinin karakteristik tepe değerlerini göstermiştir. Hücre kültürü çalışması L929 ATCC CCL-1 fare deri hücre hattı ile yürütülmüştür. Doku iskelelerinin biyouyumluluk performansı MTT tahlili, floresan mikrosbu, Lazer Taramalı Konfokal Mikroskobu (CLSM) analizleri ile saptanmıştır. Sonuçlar göstermiştir ki bu araştırmadaki üretilen mikro/nano lifli PCL/kitosan çekirdek-kabuk doku iskelelerinin üzerinde ve içine doğru hücre canlılığı ve yayılması artmıştır.Article Citation - WoS: 124Citation - Scopus: 130Novel Poly(ε-caprolactone)/Gelatin Wound Dressings Prepared by Emulsion Electrospinning With Controlled Release Capacity of Ketoprofen Anti-Inflammatory Drug(Elsevier, 2017) Basar, A. O.; Castro, S.; Torres-Giner, S.; Lagaron, J. M.; Sasmazel, H. TurkogluIn the present study, a single and binary Ketoprofen-loaded mats of ultrathin fibers were developed by electrospinning and their physical properties and drug release capacity was analyzed. The single mat was prepared by solution electrospinning of poly(e-caprolactone) (PCL) with Ketoprofen at a weight ratio of 5 wt%. This Ketoprofen-containing PCL solution was also used as the oil phase in a 7:3 (wt/wt) emulsion with gelatin dissolved in acidified water. The resultant stable oil-in-water (O/W) emulsion of PCL-in-gelatin, also containing Ketoprofen at 5 wt%, was electrospun to produce the binary mat. Cross-linking process was performed by means of glutaraldehyde vapor on the electrospun binary mat to prevent dissolution of the hydrophilic gelatin phase. The performed characterization indicated that Ketoprofen was successfully embedded in the single and binary electrospun mats, i.e. PCL and PCL/gelatin, and both mats showed high hydrophobicity but poor thermal resistance. In vitro release studies interestingly revealed that, in comparison to the single PCL electrospun mat, the binary PCL/gelatin mat significantly hindered Ketoprofen burst release and exhibited a sustained release capacity of the drug for up to 4 days. In addition, the electrospun Ketoprofen-loaded mats showed enhanced attachment and proliferation of L929 mouse fibroblast cells, presenting the binary mat the highest cell growth yield due to its improved porosity. The here-developed electrospun materials clearly show a great deal of potential as novel wound dressings with an outstanding controlled capacity to release drugs.Article Citation - WoS: 45Citation - Scopus: 46Novel Hybrid Scaffolds for the Cultivation of Osteoblast Cells(Elsevier, 2011) Sasmazel, Hilal TurkogluIn this study, natural biodegradable polysaccharide, chitosan, and synthetic biodegradable polymer, poly(epsilon-caprolactone) (PCL) were used to prepare 3D, hybrid polymeric tissue scaffolds (PCL/chitosan blend and PCL/chitosan/PCL layer by layer scaffolds) by using the electrospinning technique. The hybrid scaffolds were developed through HA addition to accelerate osteoblast cell growth. Characteristic examinations of the scaffolds were performed by micrometer, SEM, contact angle measurement system, ATR-FTIR, tensile machine and swelling experiments. The thickness of all electrospun scaffolds was determined in the range of 0.010 +/- 0.001-0.012 +/- 0.002 mm. In order to optimize electrospinning processes, suitable bead-free and uniform scaffolds were selected by using SEM images. Blending of PCL with chitosan resulted in better hydrophilicity for the PCL/chitosan scaffolds. The characteristic peaks of PCL and chitosan in the blend and layer by layer nanofibers were observed. The PCL/chitosan/PCL layer by layer structure had higher elastic modulus and tensile strength values than both individual PCL and chitosan structures. The layer by layer scaffolds exhibited the PBS absorption values of 184.2; 197.2% which were higher than those of PCL scaffolds but lower than those of PCL/chitosan blend scaffolds. SaOs-2 osteosarcoma cell culture studies showed that the highest ALP activities belonged to novel PCL/chitosan/PCL layer by layer scaffolds meaning better cell differentiation on the surfaces. (C) 2011 Elsevier B.V. All rights reserved.Article Citation - WoS: 58Citation - Scopus: 77Electrospun Oxygen Scavenging Films of Poly(3-Hydroxybutyrate) Containing Palladium Nanoparticles for Active Packaging Applications(Mdpi, 2018) Cherpinski, Adriane; Gozutok, Melike; Sasmazel, Hilal Turkoglu; Torres-Giner, Sergio; Lagaron, Jose M.This paper reports on the development and characterization of oxygen scavenging films made of poly(3-hydroxybutyrate) (PHB) containing palladium nanoparticles (PdNPs) prepared by electrospinning followed by annealing treatment at 160 degrees C. The PdNPs were modified with the intention to optimize their dispersion and distribution in PHB by means of two different surfactants permitted for food contact applications, i.e., hexadecyltrimethylammonium bromide (CTAB) and tetraethyl orthosilicate (TEOS). Analysis of the morphology and characterization of the chemical, thermal, mechanical, and water and limonene vapor barrier properties and the oxygen scavenging capacity of the various PHB materials were carried out. From the results, it was seen that a better dispersion and distribution was obtained using CTAB as the dispersing aid. As a result, the PHB/PdNP nanocomposites containing CTAB provided also the best oxygen scavenging performance. These films offer a significant potential as new active coating or interlayer systems for application in the design of novel active food packaging structures.Master Thesis İleri Periodontal Diş Çekimi Yara Yeri İyileşme Malzemeleri: Elektroeğirilmiş Çekirdek-kabuk Pcl Pcl Nanofiberler(2023) Tukay, Arı Kutluğ; Şaşmazel, Hilal TürkoğluBu çalışmanın amacı; elektroeğirme tekniği kullanarak çekirdek-kabuk PCL/PCL nanofiberlerin üretilmesinin sağlanması ve üretilen nanofiberlerin yüzeyleri dielektrik barrier discharge plazma yöntemi ile DAP monomeri kaplanarak, periodontal yara yeri bölgelerinin iyileşmesinin hızlandırılmasına katkı sağlanmasıdır. Nanofiber yapılı iskeletler çekirdek-kabuk elektroeğirme yöntemi ile üretilmiştir. Üretilen nanofiberler 1 dk., 3 dk. ve 5 dk. olarak DBD plazma işlemine tabi tutulmuş ve yüzey modifikasyonu sırasında yüzeyleri DAP monomeri ile kaplanmıştır. Örneklerin karakterizasyonları, temas açısı (CA) ölçümleri, taramalı elektron mikroskobu (SEM), geçirimli elektron mikroskobu (TEM), Fourier dönüşümü kızılötesi spektroskopisi (FTIR) ve ayrıca üretilen çekirdek-kabuk PCL/PCL nanofiberler için gaz geçirgenlik testi, mekanik testi, kalınlık ölçümleri, PBS emilim ve büzülme testleri gerçekleştirilmiştir. Viskozitelik bakımından daha fazla vizkoziteye sahip kloroform çözücünün kabukta kullanılması ile oluşturulan Grup-1 numuneleri ve kloroform çözücünün çekirde kullanılması ile üretilen Grup-2 numuneleri karşılaştırılmıştır. Ortalama fiber çap değerleri, elektroeğirme yöntemi ile üretilmiş PCL/PCL grup 1 için 1.252 ± 0.422 ve yüzey modifikasyonları sonrasında 1 dakikalık için 1.366 ± 0.211, 3 dakikalık için 1.369 ± 0.129 ve 5 dakikalık için 1.372 ± 0.230 olarak hesaplanmıştır. Grup 2 için ortalama fiber çap değerleri; 2.039 ± 0.503, v 1 dakikalık için 2.152 ± 0.705, 3 dakikalık için 2.156 ± 0.711 ve 5 dakikalık yüzey işlemine tutulmuş numuneler için 2.160 ± 0.602 olarak hesaplanmıştır. Çekirdek- kabuk PCL/PCL nanofiberlerin FTIR analizleri, DAP monomeri eklenerek DBD plazma yüzey kaplaması öncesinde ve sonrasında oluşan karakteristik polimer zirvelerini de göstermiştir. Hücre kültürü çalışmalarında L929 fare fibroblast hücre hattı ile çalışılmıştır. Nanofiberlerin biyouyumluluk performansları MTT testi, flüoresans boyama testi ve SEM analizi ile belirlenmiştir. Sonuç olarak; bu çalışmada oluşturulan Grup-2'nin elektroeğirme yöntemi ile üretilmiş ve yüzeyleri 5 dakika boyunca DBD plazma yöntemi kullanılarak DAP monomeri ile kaplanmış PCL/PCL nanofiberlerin, nanofiber yapılar üzerinde/arasında hücre canlılığını ve proliferasyonunu arttırdığı gösterilmiştir.Master Thesis Grafen Oksit (go) Modifiye Elektroeğrilmiş Poli (ε-kaprolakton) (pcl) Nanomalzemeler(2019) Başar, Ahmet Ozan; Şaşmazel, Hilal TürkoğluÇalışmanın amacı, sentetik biyobozunur polimer poli(ε-kaprolakton) (PCL) ve grafen oksit (GO) birleşiminin elektroeğrilmesiyle üç boyutlu, kompozit bir doku iskelesi elde etmektir. Ayrıca, kompozit PCL/GO yapılarının Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) ve/veya tiyofen (Th) (PCL/GO, PCL/GO-GRGDSP, PCL/GO-Th, PCL/GO-GRGDSP-Th) ile birlikte etkileşimleri incelenmiştir. Toz GO örneklerinin karakterizasyon özellikleri ATR-FTIR ve Raman analizleri ile tayin edilmiştir. Elektroeğrilmiş doku iskelelerinin karakterizasyon özellikleri ise; kalınlık ölçümleri, taramalı elektron mikroskobu (SEM), yüzey temas açısı (CA) ölçümleri, X-ışını fotoelektron spektroskopi (XPS), termogravimetrik analiz (TGA), iletkenlik ölçümleri, PBS şişme ve büzüşme davranış testleri, in vitro degradasyon (bozunma) çalışmaları ve mekanik testleri ile yapılmıştır. Bu analizler sonucunda, bütün doku iskelelerinde eşdağılımlı homojen morfoloji gözlemlenmiştir. GO eklenmesiyle PCL/GO doku iskelelerinde daha iyi hidrofilisite ve yaklaşık 5° temas açısı düşüşü gözlenmiştir. PCL ve GO birleşimi ile elektriksel iletkenlikte artış gözlenmiş ve ölçülen en yüksek değer PCL/GO-GRGDSP-Th (2%) için bulunmuştur (15.06 μS.cm-1). Doku iskelelerinin mekanik performansı ise iyi disperse (dağılmış) olmuş GO'nun PCL matriksine eklenmesiyle artmıştır. Ayrıca, üretilen doku iskelelerinin hücre-materyal etkileşimleri MG-63 hücre hattı kullanılarak; MTT tayini, ALP aktivitesi, Alizarin red boyaması, Floresan ve SEM analizleri ile incelenmiştir. Yapılan hücre kültürü çalışmaları sonucunda, GO'nun ileri düzey özellikleri ve biyolojik arayüzleri sayesinde PCL/GO-GRGDSP-Th (0.5%) doku iskelesi en yüksek biyouyumluluk (saf PCL doku iskelesine kıyasla 1.87 kat daha fazla MTT absorbansı) göstermiştir.Article Citation - WoS: 37Citation - Scopus: 45Study on the Cytocompatibility, Mechanical and Antimicrobial Properties of 3d Printed Composite Scaffolds Based on Pva/ Gold Nanoparticles (aunp)/ Ampicillin (amp) for Bone Tissue Engineering(Elsevier, 2021) Topsakal, Aysenur; Midha, Swati; Yuca, Esra; Tukay, Ari; Sasmazel, Hilal Turkoglu; Kalaskar, Deepak M.; Gunduz, OguzhanOver the years, gold nanoparticles (AuNP) have been widely used in several biomedical applications related to the diagnosis, drug delivery, bio-imaging, photo-thermal therapy and regenerative medicine, owing to their unique features such as surface plasmon resonance, fluorescence and easy surface functionality. Recent studies showed that gold nanoparticles display positive effect on osteogenic differentiation. In line with this effect, 3-Dimesional (3D) scaffolds that can be used in bone tissue were produced by exploiting the properties of gold nanoparticles that increase biocompatibility and support bone tissue development. In addition, ampicillin was added to the scaffolds containing gold nanoparticles as a model drug to improve its antimicrobial properties. The scaffolds were produced as composites of polyvinyl alcohol (PVA) main matrix as PVA, PVA/AuNP, PVA/Ampicillin (AMP) and PVA/AuNP/AMP. Scanning Electron Microscopy (SEM) Fourier Transform Infrared Spectroscopy (FTIR), tensile measurement tests, and in vitro applications of 3D scaffolds were performed. As depicted by SEM, scaffolds were produced at pore sizes appropriate for bone tissue regeneration. According to FTIR results, there was no modification observed in the AMP, PVA and gold nanoparticles due to mixing in the resultant scaffolds. In vitro results show that 3D printed composite scaffold based on PVA/AuNP/AMP are biocompatible, osteo-inductive and exhibit antimicrobial properties, compared to PVA scaffolds. This study has implications for addressing infections during orthopedic surgeries. The PVA-based gold nanoparticle 3D tissue scaffold study containing ampicillin covers a new study compared to other articles based on gold nanoparticles.
