Poly(ε-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing β-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications
dc.authorid | Hasirci, Nesrin/0000-0002-4497-0194 | |
dc.authorid | Aksoy, Eda Ayse/0000-0003-4977-0412 | |
dc.authorscopusid | 55361015700 | |
dc.authorscopusid | 55759949800 | |
dc.authorscopusid | 16302853300 | |
dc.authorscopusid | 7006131933 | |
dc.authorscopusid | 7003969314 | |
dc.authorwosid | Hasirci, Nesrin/I-4754-2018 | |
dc.authorwosid | Hasirci, Vasif Nejat/N-5285-2018 | |
dc.authorwosid | Aksoy, Eda Ayse/AAN-5519-2020 | |
dc.contributor.author | Aydemir, Ümran | |
dc.contributor.author | Arslantunali, Damla | |
dc.contributor.author | Aksoy, Eda Ayse | |
dc.contributor.author | Hasirci, Vasif | |
dc.contributor.author | Hasirci, Nesrin | |
dc.contributor.other | Chemical Engineering | |
dc.date.accessioned | 2024-07-05T14:27:34Z | |
dc.date.available | 2024-07-05T14:27:34Z | |
dc.date.issued | 2014 | |
dc.department | Atılım University | en_US |
dc.department-temp | [Sezer, Umran Aydemir; Arslantunali, Damla; Aksoy, Eda Ayse; Hasirci, Vasif; Hasirci, Nesrin] Middle E Tech Univ, Ctr Excellence Biomat & Tissue Engn, BIOMATEN, TR-06800 Ankara, Turkey; [Sezer, Umran Aydemir; Hasirci, Vasif; Hasirci, Nesrin] Middle E Tech Univ, Fac Arts & Sci, Grad Dept Biomed Engn, TR-06800 Ankara, Turkey; [Sezer, Umran Aydemir] Atilim Univ, Dept Chem Engn & Appl Chem, Fac Engn, TR-06836 Ankara, Turkey; [Arslantunali, Damla] Gumushane Univ, Dept Bioengn, Fac Engn, TR-29100 Gumushane, Turkey; [Arslantunali, Damla; Hasirci, Vasif; Hasirci, Nesrin] Middle E Tech Univ, Fac Arts & Sci, Dept Biotechnol, TR-06800 Ankara, Turkey; [Aksoy, Eda Ayse] Hacettepe Univ, Dept Basic Pharmaceut Sci, Fac Pharm, TR-06100 Ankara, Turkey; [Hasirci, Vasif] Middle E Tech Univ, Fac Arts & Sci, Dept Biol Sci, TR-06800 Ankara, Turkey; [Hasirci, Nesrin] Middle E Tech Univ, Fac Arts & Sci, Dept Chem, TR-06800 Ankara, Turkey | en_US |
dc.description | Hasirci, Nesrin/0000-0002-4497-0194; Aksoy, Eda Ayse/0000-0003-4977-0412 | en_US |
dc.description.abstract | In this study, novel poly(epsilon-caprolactone) (PCL) composite scaffolds were prepared for bone tissue engineering applications, where gentamicin-loaded -tricalcium phosphate (-TCP)/gelatin microspheres were added to PCL. The effects of the amount of -TCP/gelatin microspheres added to the PCL scaffold on various properties, such as the gentamicin release rate, biodegradability, morphology, mechanical strength, and pore size distribution, were investigated. A higher amount of filler caused a reduction in the mechanical properties and an increase in the pore size and led to a faster release of gentamicin. Human osteosarcoma cells (Saos-2) were seeded on the prepared composite scaffolds, and the viability of cells having alkaline phosphatase (ALP) activity was observed for all of the scaffolds after 3 weeks of incubation. Cell proliferation and differentiation enhanced the mechanical strength of the scaffolds. Promising results were obtained for the development of bone cells on the prepared biocompatible, biodegradable, and antimicrobial composite scaffolds. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40110. | en_US |
dc.description.sponsorship | [METU-BAP-07-02-2011-101] | en_US |
dc.description.sponsorship | This study was supported by grant METU-BAP-07-02-2011-101. | en_US |
dc.identifier.citation | 18 | |
dc.identifier.doi | 10.1002/app.40110 | |
dc.identifier.issn | 0021-8995 | |
dc.identifier.issn | 1097-4628 | |
dc.identifier.issue | 8 | en_US |
dc.identifier.scopus | 2-s2.0-84901719383 | |
dc.identifier.uri | https://doi.org/10.1002/app.40110 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14411/253 | |
dc.identifier.volume | 131 | en_US |
dc.identifier.wos | WOS:000333806100001 | |
dc.identifier.wosquality | Q2 | |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | biodegradable | en_US |
dc.subject | biomaterials | en_US |
dc.subject | composites | en_US |
dc.subject | foams | en_US |
dc.title | Poly(ε-caprolactone) Composite Scaffolds Loaded with Gentamicin-Containing β-Tricalcium Phosphate/Gelatin Microspheres for Bone Tissue Engineering Applications | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
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