Investigation of the Anti-Inflammatory Effects of Astaxanthin on Liver Tissue in Lipopolysaccharide-Induced Sepsis in Rats

dc.authorid YELKEN, BIRGUL BUYUKKIDAN/0000-0001-9677-9028
dc.authorid OZKURT, METE/0000-0003-4000-2345
dc.authorwosid özkurt, mete/ACM-2771-2022
dc.contributor.author Cobaner, Nurdan
dc.contributor.author Yelken, Birgul
dc.contributor.author Erkasap, Nilufer
dc.contributor.author Ozkurt, Mete
dc.contributor.author Bektur, Ezgi
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:17:22Z
dc.date.available 2024-07-05T15:17:22Z
dc.date.issued 2022
dc.department Atılım University en_US
dc.department-temp [Cobaner, Nurdan; Yelken, Birgul] Eskisehir Osmangazi Univ, Div Intens Care, Dept Anaesthesiol & Reanimat, Fac Med, Eskisehir, Turkey; [Erkasap, Nilufer; Ozkurt, Mete] Eskisehir Osmangazi Univ, Dept Physiol, Fac Med, Eskisehir, Turkey; [Bektur, Ezgi] Atilim Univ, Dept Histol & Embryol, Fac Med, Ankara, Turkey en_US
dc.description YELKEN, BIRGUL BUYUKKIDAN/0000-0001-9677-9028; OZKURT, METE/0000-0003-4000-2345 en_US
dc.description.abstract Objective: Corticosteroids are one of the treatment methods used to prevent inflammation in sepsis. This study aimed to determine the anti-inflammatory activity of astaxanthin in sepsis and compare it with dexamethasone. Materials and Methods: After approval of the local ethics committee, 40 Sprague-Dawley male rats were randomly assigned to the control group (n=8), lipopolysaccharide group (n=8), astaxanthin group (n=8), astaxanthin + lipopolysaccharide group (n=8) and dexamethasone + lipopolysaccharide group (n=8). On day 1, these groups were given dimethyl sulfoxide, Salmonella typhimurium lipopolysaccharide, astaxanthin dissolved in dimethyl sulfoxide, astaxanthin and lipopolysaccharide and dexamethasone and lipopolysaccharide, respectively. After 24 hours, rats underwent laparotomy, and liver and blood samples were taken. GraphPad Prism 6 was used for statistical analysis. P values less than 0.05 were considered significant. Results: Nuclear factor-kappa B levels in both treatment groups significantly decreased when compared with the lipopolysaccharide group. Apoptotic cells and reaction severity decreased significantly in the treatment groups compared with the lipopolysaccharide group. Conclusion: This study revealed that the use of astaxanthin had a positive effect on liver tissue undergoing treatment for sepsis. Moreover, despite some differences, measurement values were comparable when dexamethasone was administered. en_US
dc.description.sponsorship Eskisehir Osmangazi University Scientific Research Project Committee [2015-770] en_US
dc.description.sponsorship This study was funded by Eskisehir Osmangazi University Scientific Research Project Committee (project code: 2015-770). en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.4274/tybd.galenos.2021.52523
dc.identifier.endpage 85 en_US
dc.identifier.issn 2602-2974
dc.identifier.issue 2 en_US
dc.identifier.startpage 79 en_US
dc.identifier.trdizinid 1130809
dc.identifier.uri https://doi.org/10.4274/tybd.galenos.2021.52523
dc.identifier.uri https://hdl.handle.net/20.500.14411/1745
dc.identifier.volume 20 en_US
dc.identifier.wos WOS:000808581600003
dc.institutionauthor Bektur Aykanat, Nuriye Ezgi
dc.language.iso en en_US
dc.publisher Galenos Yayincilik en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Astaxanthin en_US
dc.subject dexamethasone en_US
dc.subject anti-inflammatory en_US
dc.subject liver en_US
dc.title Investigation of the Anti-Inflammatory Effects of Astaxanthin on Liver Tissue in Lipopolysaccharide-Induced Sepsis in Rats en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication
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