Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid\raortic valve degeneration

dc.authorid AYHAN, Hüseyin/0000-0002-9991-7307
dc.authorscopusid 56655177100
dc.authorscopusid 26530826900
dc.authorscopusid 6603167404
dc.authorscopusid 7003971982
dc.authorwosid AYHAN, Hüseyin/A-5176-2018
dc.authorwosid Karaduman, Bilge Duran/ABC-1759-2020
dc.contributor.author Karaduman, Bilge Duran
dc.contributor.author Ayhan, Hüseyin
dc.contributor.author Keles, Telat
dc.contributor.author Bozkurt, Engin
dc.date.accessioned 2024-07-05T15:41:02Z
dc.date.available 2024-07-05T15:41:02Z
dc.date.issued 2020
dc.department Atılım University en_US
dc.department-temp ATILIM ÜNİVERSİTESİ,ATILIM ÜNİVERSİTESİ,ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ,T.C. SAĞLIK BAKANLIĞI en_US
dc.description AYHAN, Hüseyin/0000-0002-9991-7307; en_US
dc.description.abstract Background/aim: From a pathophysiological point of view, inflammation is thought to be more dominant in bicuspid aortic valve\r(BAV) stenosis than tricuspid aortic valve (TAV) stenosis. Our study aimed to determine the association between monocyte to highdensity lipoprotein cholesterol (HDL-C) ratio (MHR), a new inflammatory marker, and the speed of progression of stenosis and\rpathophysiology of BAV stenosis.\rMaterials and methods: A total of 210 severe aortic stenosis patients (70 consecutive BAV patients, 140 matched TAV patients) were\rretrospectively enrolled in the study. Clinical and echocardiographic data and laboratory results related to our research were collected\rretrospectively from the patients’ records. MHR was measured as the ratio of the absolute monocyte count to the HDL-C value.\rResults: Seventy BAV (mean age: 72.0 ± 9.1 years, 42.9% female) and 140 TAV patients (mean age: 77.9 ± 8.3 years, 51.4% female)\rwith severe aortic stenosis were enrolled in this study. There was no difference between the two groups in terms of another baseline\rdemographic or clinic findings except age (P < 0.001). Monocyte count, hemoglobin level, mean platelet volume was significantly\rhigher, and HDL-C level was significantly lower in the BAV group, while other lipid and CBC parameters were found to be similar. In\rthe multivariate analysis, MHR (P = 0.005, 95% CI: 0.90–0.98) and, as expected, age (P = 0.001, 95% CI: 1.02–1.11) were found to be\rsignificant as the independent predictor of BAV, after adjusting for other risk factors.\rConclusion: Our study showed a significant correlation between increased MHR and BAV. MHR was determined as a significant\rindependent predictor for the speed of progression and diagnosis of severe BAV stenosis in multivariate analysis. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.3906/sag-2006-60
dc.identifier.endpage 1313 en_US
dc.identifier.issn 1300-0144
dc.identifier.issn 1303-6165
dc.identifier.issue 5 en_US
dc.identifier.pmid 32777897
dc.identifier.scopus 2-s2.0-85090078820
dc.identifier.scopusquality Q1
dc.identifier.startpage 1307 en_US
dc.identifier.uri https://doi.org/10.3906/sag-2006-60
dc.identifier.volume 50 en_US
dc.identifier.wos WOS:000566495700015
dc.identifier.wosquality Q3
dc.institutionauthor Karaduman, Bilge Duran
dc.institutionauthor Ayhan, Hüseyin
dc.language.iso en en_US
dc.publisher Tubitak Scientific & Technological Research Council Turkey en_US
dc.relation.ispartof Turkish Journal of Medical Sciences en_US
dc.relation.publicationcategory Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 8
dc.title Association between monocyte to high-density lipoprotein cholesterol ratio and bicuspid\raortic valve degeneration en_US
dc.type Article en_US
dc.wos.citedbyCount 8
dspace.entity.type Publication
relation.isAuthorOfPublication 0f73438e-c5d8-48a7-9ee7-f34c94ea2421
relation.isAuthorOfPublication e2abe0c2-2077-48dd-9867-1fcddc073f93
relation.isAuthorOfPublication.latestForDiscovery 0f73438e-c5d8-48a7-9ee7-f34c94ea2421

Files