Laboratory and Imaging Evaluation of Cardiac Involvement in Patients With Post-Acute Covid-19

dc.contributor.author Saricam, Ersin
dc.contributor.author Dursun, Ali Dogan
dc.contributor.author Sariyildiz, Gulcin Turkmen
dc.contributor.author Can, Nalan
dc.contributor.author Bozkurt, Engin
dc.contributor.author Gonullu, Ugur
dc.contributor.author Unlu, Mustafa
dc.contributor.other Anesthesia Program
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:19:27Z
dc.date.available 2024-07-05T15:19:27Z
dc.date.issued 2021
dc.description Dursun, Ali Dogan/0000-0001-9056-0025; GONULLU, UGUR/0000-0002-4360-7297 en_US
dc.description.abstract Background: In the post-acute COVID-19 syndrome, many patients suffer from palpitations, effort-associated fatigue, and even sudden death. The mechanism of heart involvement in this syndrome is uncertain. The main purpose of the study was to identify possible cardiac involvement causes in patients with post-acute COVID-19 by using biomarkers such as NT-proBNP and nitric oxide (NO) and cardiac imaging modalities. Methods: In this cross-sectional study, a total of 105 participants were included according to the existence of symptoms, and 40 of these participants were asymptomatic patients. The ages of the participants ranged from 20 to 50 years. All patients were healthy before COVID-19. The symptoms were defined as palpitations and/or fatigue association with exercise in post-acute COVID-19 term. The comparison of the two groups was made by using biochemical parameters (NT-proBNP, Troponin I, NO) and imaging techniques (echocardiography, cardiovascular magnetic resonance (CMR) and cardiac positron emission tomography (PET)). Results: The symptomatic patients had higher NT-proBNP levels compared with asymptomatic patients (132.30 +/- 35.15; 76.86 +/- 16.79, respectively; p < 0.001). Interestingly, the symptomatic patients had lower NO levels than asymptomatic patients (9.20 +/- 3.08; 16.15 +/- 6.02, respectively; p < 0.001). Echocardiography and CMR were normal. However, we found regional increased 18F-FDG uptake on cardiac PET to be compatible with myocardial fatigue. Conclusion: We found elevated NT-proNBP levels, low serum NO levels, and increased 18F-FDG uptake on cardiac PET in post-acute COVID syndrome. Cardiac PET could replace or be added to CMR for detecting subtle subacute/chronic myocarditis. The follow-up of patients with post-acute COVID-19 could target the possibility of risk of heart failure. en_US
dc.description.sponsorship Medicana International Ankara Hospital; Atilim University School of medicine en_US
dc.description.sponsorship This work was supported by Medicana International Ankara Hospital and Atilim University School of medicine. None of the funding sources had an influence on the design or production of the article. en_US
dc.identifier.doi 10.2147/IJGM.S321153
dc.identifier.issn 1178-7074
dc.identifier.uri https://doi.org/10.2147/IJGM.S321153
dc.identifier.uri https://hdl.handle.net/20.500.14411/1949
dc.language.iso en en_US
dc.publisher Dove Medical Press Ltd en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject post-acute COVID-19 en_US
dc.subject cardiac involvement en_US
dc.subject laboratory tests en_US
dc.subject imaging en_US
dc.title Laboratory and Imaging Evaluation of Cardiac Involvement in Patients With Post-Acute Covid-19 en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.id Dursun, Ali Dogan/0000-0001-9056-0025
gdc.author.id GONULLU, UGUR/0000-0002-4360-7297
gdc.author.institutional Sarıçam, Ersin
gdc.author.institutional Sarıyıldız, Gülçin Türkmen
gdc.author.institutional Can, Nalan
gdc.author.institutional Dursun, Ali Doğan
gdc.author.institutional Gönüllü, Uğur
gdc.author.wosid Dursun, Ali Dogan/AAH-7617-2019
gdc.author.wosid GONULLU, UGUR/KDP-2110-2024
gdc.coar.access metadata only access
gdc.coar.type text::journal::journal article
gdc.description.department Atılım University en_US
gdc.description.departmenttemp [Saricam, Ersin; Bozkurt, Engin] Medicana Int Ankara Hosp, Dept Cardiol, Sogutozu Cd 2165 Sokak 6, TR-06520 Ankara, Turkey; [Saricam, Ersin] Atilim Univ, Dept Cardiol, Med Sch, Ankara, Turkey; [Dursun, Ali Dogan] Atilim Univ, Dept Physiol, Med Sch, Ankara, Turkey; [Dursun, Ali Dogan] Medicana Int Ankara Hosp, Check Up Ctr, Home Care Serv, Ankara, Turkey; [Sariyildiz, Gulcin Turkmen] Medicana Int Ankara Hosp, Dept Gen Surg, Ankara, Turkey; [Sariyildiz, Gulcin Turkmen] Atilim Univ, Vocat Sch Hlth Serv, Operating Room Serv, Ankara, Turkey; [Can, Nalan] Medicana Int Ankara Hosp, Dept Nucl Med, Ankara, Turkey; [Gonullu, Ugur] Atilim Univ, Dept Pulm Med, Med Sch, Ankara, Turkey; [Basay, Nihal] Medicana Int Ankara Hosp, Dept Pulm Med, Ankara, Turkey; [Turkmen, Meral] Medicana Int Ankara Hosp, Dept Internal Med, Ankara, Turkey; [Denli, Abdulaziz] Medicana Int Ankara Hosp, Dept Phys Med & Rehabil, Ankara, Turkey; [Unlu, Mustafa] Gazi Univ, Dept Nucl Med, Med Sch, Ankara, Turkey en_US
gdc.description.endpage 4985 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.startpage 4977 en_US
gdc.description.volume 14 en_US
gdc.identifier.pmid 34511982
gdc.identifier.wos WOS:000691613900011
gdc.wos.citedcount 18
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