Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorscopusid 57222728850
dc.authorscopusid 59158728000
dc.authorscopusid 16680382000
dc.contributor.author Alazzawi, Marwa
dc.contributor.author Alsahib, Nabeel Kadim Abid
dc.contributor.author Sasmazel, Hilal Turkoglu
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T15:17:00Z
dc.date.available 2024-07-05T15:17:00Z
dc.date.issued 2021
dc.department Atılım University en_US
dc.department-temp [Alazzawi, Marwa; Alsahib, Nabeel Kadim Abid] Al Nahrain Univ, Dept Biomed Engn, Baghdad 64074, Iraq; [Sasmazel, Hilal Turkoglu] Atilim Univ, Dept Met & Mat Engn, TR-06830 Incek, Golbasi, Turkey en_US
dc.description Turkoglu Sasmazel, Hilal/0000-0002-0254-4541 en_US
dc.description.abstract Glycine (Gly), which is the simplest amino acid, induces the inflammation response and enhances bone mass density, and particularly its beta polymorph has superior mechanical and piezoelectric properties. Therefore, electrospinning of Gly with any polymer, including polyvinyl alcohol (PVA), has a great potential in biomedical applications, such as guided bone regeneration (GBR) application. However, their application is limited due to a fast degradation rate and undesirable mechanical and physical properties. Therefore, encapsulation of Gly and PVA fiber within a poly(epsilon-caprolactone) (PCL) shell provides a slower degradation rate and improves the mechanical, chemical, and physical properties. A membrane intended for GBR application is a barrier membrane used to guide alveolar bone regeneration by preventing fast-proliferating cells from growing into the bone defect site. In the present work, a core/shell nanofibrous membrane, composed of PCL as shell and PVA:Gly as core, was developed utilizing the coaxial electrospinning technique and characterized morphologically, mechanically, physically, chemically, and thermally. Moreover, the characterization results of the core/shell membrane were compared to monolithic electrospun PCL, PVA, and PVA:Gly fibrous membranes. The results showed that the core-shell membrane appears to be a good candidate for GBR application with a nano-scale fiber of 412 +/- 82 nm and microscale pore size of 6.803 +/- 0.035 mu m. Moreover, the wettability of 47.4 +/- 2.2 degrees contact angle (C.A) and mechanical properties of 135 +/- 3.05 MPa average modulus of elasticity, 4.57 +/- 0.04 MPa average ultimate tensile stress (UTS), and 39.43% +/- 0.58% average elongation at break are desirable and suitable for GBR application. Furthermore, the X-ray diffraction (XRD) and transmission electron microscopy (TEM) results exhibited the formation of beta-Gly. en_US
dc.identifier.citationcount 8
dc.identifier.doi 10.3390/coatings11091130
dc.identifier.issn 2079-6412
dc.identifier.issue 9 en_US
dc.identifier.scopus 2-s2.0-85115397967
dc.identifier.uri https://doi.org/10.3390/coatings11091130
dc.identifier.uri https://hdl.handle.net/20.500.14411/1706
dc.identifier.volume 11 en_US
dc.identifier.wos WOS:000699307900001
dc.identifier.wosquality Q2
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Mdpi en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 13
dc.subject glycine en_US
dc.subject GBR en_US
dc.subject coaxial en_US
dc.subject core-shell en_US
dc.subject electrospinning en_US
dc.subject encapsulation en_US
dc.title Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization en_US
dc.type Article en_US
dc.wos.citedbyCount 12
dspace.entity.type Publication
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