Effects of Carbon Dioxide Pneumoperitoneum on Renal Function in Obstructive Jaundice: an Experimental Study in a Rat Model

dc.authorscopusid 40261432600
dc.authorscopusid 6604060451
dc.authorscopusid 56364593500
dc.authorscopusid 57209093849
dc.authorscopusid 16244695100
dc.authorscopusid 6602928897
dc.authorscopusid 6602928897
dc.authorwosid Deger, Serpil Muge/Abg-5774-2021
dc.authorwosid Senes, Mehmet/Aag-6802-2019
dc.authorwosid Kozan, Ramazan/A-2266-2019
dc.contributor.author Gulen, Merter
dc.contributor.author Sare, Mustafa
dc.contributor.author Kozan, Ramazan
dc.contributor.author Yuksel, Seher
dc.contributor.author Deger, Serpil Muge
dc.contributor.author Senes, Mehmet
dc.contributor.author Cayci, Ayse Banu
dc.date.accessioned 2025-03-05T20:46:59Z
dc.date.available 2025-03-05T20:46:59Z
dc.date.issued 2023
dc.department Atılım University en_US
dc.department-temp [Gulen, Merter] Atilim Univ, Fac Med, Dept Gen Surg, Ankara, Turkiye; [Sare, Mustafa; Kozan, Ramazan] Gazi Univ, Fac Med, Dept Gen Surg, Ankara, Turkiye; [Yuksel, Seher] UT Southwestern Med Ctr, Dept Ophthalmol, Dallas, TX USA; [Deger, Serpil Muge] Dokuz Eylul Univ, Fac Med, Dept Nephrol, Izmir, Turkiye; [Senes, Mehmet] Ankara Numune Training & Res Hosp, Dept Biochem, Ankara, Turkiye; [Cayci, Ayse Banu] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkiye en_US
dc.description.abstract Introduction: Both pneumoperitoneum (PNP) and obstructive jaundice (OJ) are known to lead to acute kidney injury (AKI) potentially, but the combined effect has not been investigated. Aim: This study aimed to investigate the effects of PNP on renal functions in a rat model of OJ. Methods: We divided forty-eight rats into eight groups of six rats. Group 1 was the control (sham-operated) group; Groups 2, 3, and 4 were induced 5, 10, and 15 mmHg of CO2 PNP, respectively (Groups 1-4: "non-OJ Groups"); Group 5 was the OJ group; and Groups 6, 7 and 8 were OJ groups that were induced with 5, 10, and 15 mmHg CO2 PNP was respectively (Groups 5-8: "OJ Groups"). The common bile duct was ligated and divided into OJ Groups. After 48 hours, a 5-10-15 mmHg PNP was induced by mini-laparotomy with a Veress needle in Groups 6, 7, and 8, maintained for 60 minutes. Results: There were no statistically significant differences between groups regarding blood urea Nitrogen and Creatinin levels (p> 0.05). Neutrophil gelatinase-associated lipocalin (NGAL) values were significantly higher in OJ Groups than in non-OJ Groups (p< 0.05). Serum Cystatin-C values were significantly higher in OJ Groups with 10 and 15 mmHg PNP than in nonOJ Groups (p< 0.05). Conclusion: In the early stage of AKI, NGAL and Cystatin-C levels might be higher, while standard renal function tests were normal. Our findings highlight the apparent unfavorable effect of OJ with PNP on renal functions and early recognition of AKI with the measurement of NGAL and Cystatin-C in these conditions. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.endpage 147 en_US
dc.identifier.issn 0326-3428
dc.identifier.issn 2346-8548
dc.identifier.issue 3 en_US
dc.identifier.scopus 2-s2.0-85172407287
dc.identifier.scopusquality Q4
dc.identifier.startpage 138 en_US
dc.identifier.uri https://hdl.handle.net/20.500.14411/10451
dc.identifier.volume 43 en_US
dc.identifier.wos WOS:001163662800003
dc.identifier.wosquality Q4
dc.language.iso en en_US
dc.publisher Asoc Regional Dialisis Trasplantes Renales en_US
dc.relation.ispartof Revista de Nefrologia, Dialisis y Trasplante en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 1
dc.subject Acute Kidney Injury (Aki) en_US
dc.subject Cystatin-C en_US
dc.subject Laparoscopy en_US
dc.subject Neutrophil Gelatinase Associated Lipocalin (Ngal) en_US
dc.subject Obstructive Jaundice (Oj) en_US
dc.subject Pneumoperitoneum (Pnp) en_US
dc.title Effects of Carbon Dioxide Pneumoperitoneum on Renal Function in Obstructive Jaundice: an Experimental Study in a Rat Model en_US
dc.title.alternative Efectos Del Neumoperitoneo Por Dióxido De Carbono Sobre La Función Renal En La Ictericia Obstructiva: Un Estudio Experimental En Un Modelo De Rata en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

Files

Collections