Concentration dependent different action of progesterone on the order, dynamics and hydration states of the head group of dipalmitoyl-phosphatidylcholine membrane

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Date

2005

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Hindawi Ltd

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Physics Group
Atılım University Physics Division was established with the purpose of educating the first-year students of the Engineering and other Departments by providing the general physics courses and, in addition, to make scientific and technological researches at the universal level. Now adays, Physics Division provide the students of Engineering, School of Aviation and Mathematics Departments with the general physics lectures having international education quality. We have in the Group the facilities of the mechanics and electricity laboratories, where the students have the opportunity to realize the practice of the theoretical knowledge in physics. Beside the compulsory courses (General Physics I and General Physics II) there are also elective courses offered by the Group. The faculty members in the Group, whose research interests and fields are given in web-page of the Group in details, perform theoretical as well as experimental researches and make publications in SSC-index journals. Graduate program, with master of sciences and doctorate degree courses and theses, is offered in different scientific areas (for details, see the web-page of the Division). In the Physcis Division there are 6 faculty members, five research assistants, and one technician.

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Abstract

Interactions of progesterone with zwitterionic dipalmitoyl phosphatidylcholine (DPPC) multilamellar liposomes (MLVs) were investigated as a function of progesterone concentration at selected temperatures monitoring both the gel and liquid crystalline phase, by using Fourier Transform Infrared spectroscopy (FTIR). It has been show that the effect of progesterone on membrane dynamics is dependent on progesterone concentration. At 1 mol%, which is close to physiological level, progesterone behaves differently. At this concentration the decrease in dynamics is more noticeable. Additionally a dramatic decrease in the strength of hydrogen bonding in the interfacial region of the bilayer is also observed. When concentration increases up to 12 mol% opposite behaviour is observed at all interactions. Above 12 mol%, progesterone-DPPC interactions shows almost linear plot.

Description

Korkmaz, Filiz/0000-0003-3512-3521; Severcan, Feride/0000-0002-1717-2517

Keywords

DPPC liposome, progesterone, FTIR, membrane fluidity, lipid order

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Citation

5

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Volume

19

Issue

4

Start Page

213

End Page

219

URI

https://doi.org/10.1155/2005/641043
 https://hdl.handle.net/20.500.14411/1227

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