Comparison of Cellular Proliferation on Dense and Porous Pcl Scaffolds

dc.authorid Turkoglu Sasmazel, Hilal/0000-0002-0254-4541
dc.authorscopusid 16680382000
dc.authorscopusid 6701671144
dc.authorscopusid 8218740800
dc.authorscopusid 7006320968
dc.authorwosid ONUR, MEHMET ALİ/G-9137-2013
dc.contributor.author Sasmazel, Hilal Tuerkoglu
dc.contributor.author Gumusderelioglu, Menemse
dc.contributor.author Gurpinar, Aylin
dc.contributor.author Onur, Mehmet Ali
dc.contributor.other Metallurgical and Materials Engineering
dc.date.accessioned 2024-07-05T14:34:09Z
dc.date.available 2024-07-05T14:34:09Z
dc.date.issued 2008
dc.department Atılım University en_US
dc.department-temp [Gumusderelioglu, Menemse] Hacettepe Univ, Dept Chem Engn, TR-06532 Ankara, Turkey; [Gumusderelioglu, Menemse] Hacettepe Univ, Dept Bioengn, TR-06532 Ankara, Turkey; [Gurpinar, Aylin; Onur, Mehmet Ali] Hacettepe Univ, Dept Biol, TR-06532 Ankara, Turkey; [Sasmazel, Hilal Tuerkoglu] Atilim Univ, Dept Mat Engn, Ankara, Turkey en_US
dc.description Turkoglu Sasmazel, Hilal/0000-0002-0254-4541 en_US
dc.description.abstract In this contribution, PCL (poly-e caprolactone) scaffolds were prepared by solvent-casting/particle-leaching technique in the presence of two pore formers, PEG(4000) or sucrose molecules in different quantities (0, 10, 20, 30, 40, 50, 55 w/w% PEG(4000)/PCL; 10, 20 w/w% Sucrose/ PCL). The surface and bulk properties of the resulting scaffolds were studied by SEM, DSC and FTIR. SEM photographs showed that, macroporosity was obtained in the PCL structures prepared with sucrose crystals while microporous structure was obtained in the presence of PEG(4000) molecules. Average pore diameters calculated from SEM photographs were 40.1 and 191.2 mu m for 40% PEG(4000)/PCL and 10% Sucrose/PCL scaffolds, respectively. The DSC and FTIR results confirmed that there is no any interaction between pore formers and PCL during structural formation, and both pore formers, PEG(4000) and sucrose, remained independently in the scaffolds. L929 mouse fibroblast cells were seeded onto PCL structures and maintained during 7 days to evaluate cell proliferation. Cell culture results showed that, 10% Sucrose/ PCL scaffold was the most promising substrate for L929 cell growth due to 3-D architecture and macroporous structure of the scaffold. en_US
dc.identifier.citationcount 27
dc.identifier.doi 10.3233/BME-2008-0515
dc.identifier.endpage 128 en_US
dc.identifier.issn 0959-2989
dc.identifier.issn 1878-3619
dc.identifier.issue 3 en_US
dc.identifier.pmid 18725692
dc.identifier.scopus 2-s2.0-50249090890
dc.identifier.startpage 119 en_US
dc.identifier.uri https://doi.org/10.3233/BME-2008-0515
dc.identifier.uri https://hdl.handle.net/20.500.14411/1026
dc.identifier.volume 18 en_US
dc.identifier.wos WOS:000259231000002
dc.identifier.wosquality Q4
dc.institutionauthor Şaşmazel, Hilal Türkoğlu
dc.language.iso en en_US
dc.publisher Ios Press en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 25
dc.subject poly(epsilon-caprolactone) en_US
dc.subject poly(ethylene glycol) en_US
dc.subject sucrose porous structures en_US
dc.subject L929 mouse fibroblasts en_US
dc.subject tissue engineering en_US
dc.title Comparison of Cellular Proliferation on Dense and Porous Pcl Scaffolds en_US
dc.type Article en_US
dc.wos.citedbyCount 23
dspace.entity.type Publication
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