The Effects of Eryngium campestre Extracts on Glutathione-S-Transferase, Glutathione Peroxidase and Catalase Enzyme Activities;
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Date
2014
Authors
Güneş,M.G.
İşgör,B.S.
İşgör,Y.G.
Shomali Moghaddam,N.
Geven,F.
Yildirim,Ö.
Journal Title
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Publisher
Turkish Pharmacists Association
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Abstract
Eryngium campestre L. (Apiaceae) are known in Turkish folk medicine as ‘Bogadikeni’ and wildly distributed in all parts of Turkey. Infusion of different parts of this species are well known as diuretic, appetizer and stimulant. In the present study, methanol extracts from flowers and leaves of E. campestre were evaluated for their potential medicinal value in terms of biological targets participate in antioxidant defense such as glutathione-S-transferase (GST), glutathione peroxidase (GPx) and catalase (CAT). Results obtained show that the methanol extract of flowers were found to have higher amount of phenolic and flavonoid contents than the leaves. The evaluation of extracts against biological target revealed that, the maximum GST enzymes inhibition activities was observed with methanol extract from flowers of E. campestre with IC50 value of 363 ng/mL. In this study, none of the extracts evaluated were shown any reasonable GPx and CAT inhibition. © 2014, Turkish Pharmacists Association. All rights reserved.
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Keywords
Catalase, Eryngium campestre, Glutathione peroxidase, Glutathione-S-transferase
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Fields of Science
Citation
9
WoS Q
Scopus Q
Q3
Source
Turkish Journal of Pharmaceutical Sciences
Volume
11
Issue
3
Start Page
339
End Page
346