Irisin Pathways in Hearts of Type 1 Diabetic Adult Male Rats Following 6 Weeks of Moderate and High-Volume Aerobic Exercise on a Treadmill

dc.authorid Dursun, Ali Dogan/0000-0001-9056-0025
dc.authorid ÇELİK, HÜMEYRA/0000-0002-3394-2438
dc.authorid Bastug, M/0000-0002-8008-6515
dc.authorid OMERCIOGLU, Goktug/0000-0002-4387-4598
dc.authorscopusid 57224357578
dc.authorscopusid 57196954194
dc.authorscopusid 57210943925
dc.authorscopusid 57219303127
dc.authorscopusid 6506192760
dc.authorwosid Dursun, Ali Dogan/AAH-7617-2019
dc.authorwosid TATAR, YAKUP/KIL-1278-2024
dc.authorwosid ÇELİK, HÜMEYRA/AFC-0770-2022
dc.authorwosid Bastug, M/AAG-9381-2020
dc.contributor.author Celik, Humeyra
dc.contributor.author Dursun, Ali Dogan
dc.contributor.author Tatar, Yakup
dc.contributor.author Omercioglu, Goktug
dc.contributor.author Bastug, Metin
dc.contributor.other Basic Sciences
dc.date.accessioned 2024-07-05T15:18:33Z
dc.date.available 2024-07-05T15:18:33Z
dc.date.issued 2023
dc.department Atılım University en_US
dc.department-temp [Celik, Humeyra] Bolu Abant Izzet Baysal Univ Karakoy, Sch Med, Physiol Dept, 15 Temmuz Demokrasi Bulvari, TR-14030 Merkez Bolu, Turkey; [Dursun, Ali Dogan] Atilim Univ, Sch Med, Physiol Dept, Ankara, Turkey; [Tatar, Yakup] TOBB Univ, Sch Med, Physiol Dept, Ankara, Turkey; [Omercioglu, Goktug; Bastug, Metin] Ankara Univ, Sch Med, Physiol Dept, Ankara, Turkey en_US
dc.description Dursun, Ali Dogan/0000-0001-9056-0025; ÇELİK, HÜMEYRA/0000-0002-3394-2438; Bastug, M/0000-0002-8008-6515; OMERCIOGLU, Goktug/0000-0002-4387-4598 en_US
dc.description.abstract Purpose Exercise-mediated protection from cardiomyopathy in diabetes through myokines raises the question of what volume of exercise should be performed. Irisin pathway molecules (consisting of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), irisin, peroxisome proliferator-activated receptors-alpha (PPAR-alpha) and uncoupling protein 1 (UCP1)), which have been shown to be mostly expressed in the heart, are thought to have beneficial effects on diabetic heart. The aim of the study is to evaluate the effects of different exercise protocols on irisin pathway in Type 1 diabetic heart. Methods Diabetic (60 mg/kg streptozotocin i.p.) and healthy Wistar Albino rats (n = 60) were trained under moderate and high-volume exercise protocols on rat treadmill for 6 weeks. After killing, mRNA transcript and protein abundance of PGC-1 alpha, irisin, PPAR-alpha, and UCP1 were determined in the left ventricles of healthy and diabetic rats. Results PPAR-alpha, FNDC5, and UCP1 mRNA levels increased significantly in healthy moderate-volume exercise group (HMVE) compared to healthy high-volume exercise (HHVE) and diabetic moderate-volume exercise groups (DMVE). Moreover, protein levels of irisin and UCP1 also elevated significantly in the diabetic high-volume exercise group (DHVE) compared to the healthy control group (HC), although there was no significant difference between the groups in PPAR-alpha. Conclusion Irisin and UCP1 protein values increased due to HHEV in the heart of Type 1 diabetic rats, but PPAR-alpha values did not change; it shows that HHEV is suitable for the heart of Type 1 diabetic rats in terms of the benefits of the pathway of irisin. en_US
dc.description.sponsorship Ankara University Research Funds [17L0230010, 15A0230006] en_US
dc.description.sponsorship This study was funded by Ankara University Research Funds (17L0230010 and 15A0230006). en_US
dc.identifier.citationcount 1
dc.identifier.doi 10.1007/s11332-022-00924-1
dc.identifier.endpage 605 en_US
dc.identifier.issn 1824-7490
dc.identifier.issn 1825-1234
dc.identifier.issue 2 en_US
dc.identifier.scopus 2-s2.0-85127303722
dc.identifier.scopusquality Q3
dc.identifier.startpage 597 en_US
dc.identifier.uri https://doi.org/10.1007/s11332-022-00924-1
dc.identifier.uri https://hdl.handle.net/20.500.14411/1852
dc.identifier.volume 19 en_US
dc.identifier.wos WOS:000773183700001
dc.institutionauthor Dursun, Ali Doğan
dc.language.iso en en_US
dc.publisher Springernature en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.scopus.citedbyCount 3
dc.subject Type 1 diabetes mellitus en_US
dc.subject Exercise intensity en_US
dc.subject Irisin en_US
dc.subject Diabetic cardiomyopathy en_US
dc.subject FNDC5 en_US
dc.subject Heart en_US
dc.title Irisin Pathways in Hearts of Type 1 Diabetic Adult Male Rats Following 6 Weeks of Moderate and High-Volume Aerobic Exercise on a Treadmill en_US
dc.type Article en_US
dc.wos.citedbyCount 2
dspace.entity.type Publication
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