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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14411/18

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  • Article
    Investigation of Tetanus Seropositivity Levels in Adult Patients with Rabies Risk Exposure Admitted To a Hospital in Ankara
    (J Infection Developing Countries, 2025) Gurkaynak, Pinar; Demircan, Serife A.; Tulek, Necla; Kinikli, Sami; Erdinc, Fatma S.; Tuncer, Gunay
    Introduction: This study aimed to assess tetanus seropositivity levels among adult patients admitted to a tertiary care hospital following rabies risk exposure, and to explore potential factors influencing their immunological status. Methodology: This cross-sectional descriptive epidemiological study included 182 adult individuals (68 females and 114 males) who presented to the hospital following rabies risk exposure. The demographic data was collected during a face-to-face interview, and the tetanus antibody concentrations were assessed using a micro-enzyme-linked immunosorbent assay (ELISA) kit. Serum antibody levels of >= 0.1 IU/mL were defined as "seropositive", while values below this threshold were considered "seronegative". Results: Seropositivity was identified in 81.9% of the patients. There was a significant decline in antibody levels with age (p < 0.001). The Spearman correlation analysis showed a moderately significant negative correlation between age and antibody titers (r = - 0.404, p < 0.001). In addition, there were significantly higher tetanus antibody levels in patients from urban areas, those vaccinated during pregnancy, and those vaccinated within the past 10 years (p = 0.025, 0.036, and 0.013, respectively). Conclusions: Overall, the results highlight a reduction in tetanus antibody levels with age, emphasizing the importance of receiving a booster dose every 10 years. In addition, rabies risk exposure, particularly in older adults, presents a valuable opportunity to administer tetanus vaccination.
  • Article
    Türkiye’de Fizyoterapi ve Rehabilitasyon Alanında, Öğrenci, Akademisyen ve Klinisyen Bakış Açısıyla Kanıta Dayalı Uygulamanın Yeri: Pilot Çalışma
    (Turkey Assoc Physiotherapists, 2025) Akınoğlu, Bihter; Bengüboz, Fatma Büşra; Arıkan, Zeynep
    Amaç: Kanıta dayalı uygulama (KDU), yüksek kaliteli klinik araştırmalara ve uygulamalara dayanan bir yöntemdir. Dünya Fizyoterapi Konfederasyonu’na göre KDU eğitimi fizyoterapi uygulama önerilerinin başında gelmelidir. Çalışmamızın amacı Türkiye’de fizyoterapi ve rehabilitasyon alanında, öğrenci, akademisyen ve klinisyen bakış açısıyla KDU’nun yerini ve önündeki engelleri araştırmaktır. Yöntem: Çalışma pilot çalışma olarak planlanmıştır. Çalışma süresince ulaşılabilecek bütün fizyoterapi ve rehabilitasyon alanında olan öğrenci, akademisyen ve klinisyenler ile çalışma gerçekleştirilmiştir. Değerlendirmede 28 sorudan oluşan “KDU Ölçeği” ve çalışmacılar tarafından hazırlanan KDU konusundaki görüşler, bilgi seviyesi, önündeki engellerin sorgulandığı bir form kullanılmıştır. Çalışma verileri web tabanlı bir form oluşturularak toplanmıştır. Bulgular: Çalışmamız 44 öğrenci, 22 akademisyen ve 31 klinisyen olmak üzere toplam 97 kişi ile gerçekleştirilmiştir. KDU’yu engelleyen faktörler cevaplarında “Order (tedavide hekim talimatı) almak” öğrencilerde %51,06, akademisyenlerde ve %31,57 klinisyenlerde %33,33 oranla ilk engel olarak belirtilmiştir. KDU ölçeği toplam puanları üç grup arasında karşılaştırıldığında istatistiksel olarak anlamlı farklar olduğu tespit edilmiştir (p=0,000). Sonuç: Çalışmamızın sonuçlarına bakıldığında farklı alanlarda bulunan fizyoterapistlerin KDU bilgi ve tutumlarının farklılıklar gösterdiği fakat ortak olarak Türkiye’de fizyoterapi ve rehabilitasyon alanında, öğrencilerin, klinisyenlerin ve akademisyenlerin KDU zorlaştırıcılarının başında “Order almak” faktörünün olduğu görülmüştür.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    Physics-Informed Neural Network for Nonlinear Bending Analysis of Nano-Beams: A Systematic Hyperparameter Optimization
    (MDPI, 2025) Esfahani, Saba Sadat Mirsadeghi; Fallah, Ali; Aghdam, Mohammad Mohammadi; Mohammadi Aghdam, Mohammad; Mirsadeghi Esfahani, Saba Sadat
    This paper investigates the nonlinear bending analysis of nano-beams using the physics-informed neural network (PINN) method. The nonlinear governing equations for the bending of size-dependent nano-beams are derived from Hamilton's principle, incorporating nonlocal strain gradient theory, and based on Euler-Bernoulli beam theory. In the PINN method, the solution is approximated by a deep neural network, with network parameters determined by minimizing a loss function that consists of the governing equation and boundary conditions. Despite numerous reports demonstrating the applicability of the PINN method for solving various engineering problems, tuning the network hyperparameters remains challenging. In this study, a systematic approach is employed to fine-tune the hyperparameters using hyperparameter optimization (HPO) via Gaussian process-based Bayesian optimization. Comparison of the PINN results with available reference solutions shows that the PINN, with the optimized parameters, produces results with high accuracy. Finally, the impacts of boundary conditions, different loads, and the influence of nonlocal strain gradient parameters on the bending behavior of nano-beams are investigated.
  • Article
    The Effect of Endurance-Based Sports on Athlete Success and Psychological Well-Being
    (Campus Educa Sports Sl, 2025) Ozpinar, Saliha; Yucel, Ali Serdar; Korkmaz, Murat; Oztas, Dilek; Kuyucu, Mihalis Michael; Aras, Goksen; Yüce, Ali Serdar
    The aim of this study is to examine the effects of psychological resilience on sport success and mental health. The relationships between commitment, control and challenge, which are sub-dimensions of psychological resilience, and sport success and psychological wellbeing were evaluated and discussed in detail. Today, the problems arising due to the increasing competitive environment and stress factors have made it more important for athletes to be psychologically strong. Although the relationship between psychological resilience and sport success has been previously examined in the literature, studies evaluating the individual effects of the sub-dimensions of resilience in a large sample group are quite limited. This study aims to overcome this deficiency and make an up-to-date contribution to the subject. A total of 684 students (72 percent male, 28 percent female) studying at the Faculties of Sport Sciences of 16 universities in Istanbul, Ankara, Izmir, Bursa and Antalya participated in the study. Participants completed the Resilience Scale and Mental Health Inventory, and their sporting achievements were evaluated by their coaches using the Sport Achievement Scale. Data were collected via Google Forms (R) and analysed using SPSS 22.0 software with correlation, regression and Granger causality tests. The findings revealed that all resilience sub-dimensions showed positive and significant relationships with sport achievement ( R-2=0.93) and psychological well-being (R-2=0.68). Especially control and challenge factors had the strongest effects. As a result of the research, commitment, control and challenge, which are the sub-dimensions of psychological resilience, significantly affect both success levels and psychological well-being of athletes. Therefore, resilience development programmes for athletes should focus on these areas.
  • Conference Object
    Fcnc Decays of Spin-1/2 Double Heavy Baryons To Spin-3/2 Single Heavy Baryons
    (E D P Sciences, 2024) Aliev, Tahmasib; Askan, Emre; Ozpineci, Altug; Sarac, Yasemin
    In recent years, there have been many discoveries in the spectroscopy of hadrons containing heavy quarks. Almost all baryons containing a single heavy quark are discovered in experiments. The quark model predicts the existence of many baryons with double heavy quarks. Among the possible double heavy baryons, only Xi(+)(cc) and Xi(++)(cc) have been experimentally observed in LHCb. Flavor-changing neutral current (FCNC) processes represent a promising platform for precise testing of SM and looking for new physics beyond the SM. In this study, the weak decays of spin-1/2 double heavy baryons to spin3/2 single heavy baryons induced by FCNC are studied within the light cone QCD sum rules method. First, the transition form factors of Xi(0,-)(bb) -> Xi(*0,(l) over bar l)(b), Xi(0,-)(bb) -> Sigma(*0,(l) over bar l)(b), Omega(-)(bb) -> Sigma(b)*(-(l) over barl), Omega(-)(bb) -> Sigma(*0,(l) over bar l)(b) decays are calculated. Then, the corresponding decay widths are estimated using the results for the form factors.
  • Article
    Suç Gelirlerinin Aklanması ve Vergi Suçları İlişkisinin Mali Eylem Görev Gücü (FATF) Standartları Temelinde İncelenmesi: Türkiye için Bir Durum Değerlendirmesi
    (Sosyoekonomi Soc, 2025) Bülbül, Duran; Güler, Kadir
    Suç gelirlerinin aklanması ve vergi suçları, topluma maliyeti yüksek olan finansal suçlar olup, aralarında önemli bağlantılar bulunmaktadır. Bu çalışmada Mali Eylem Görev Gücü (Financial Action Task Force - FATF) tarafından aklama suçuna karşı getirilen tedbirlerin vergi uyumuna ve vergi suçları ile mücadeleye olan katkılarının incelenmesi ve Türkiye’deki durumun değerlendirilmesi amaçlanmıştır. Bu kapsamda öncelikle bu suçlara ve aralarındaki bağlantılara ilişkin kavramsal çerçeve oluşturulmuş, daha sonra FATF standartları temelinde aklama suçlarına karşı getirilen tedbirlerin genel olarak vergi uyumu ve vergi suçlarına etkileri araştırılmış ve Türkiye’deki durum incelenerek analiz edilmiştir. Yapılan çalışma müşterinin tanınması ve şüpheli işlemlerin bildirilmesine ilişkin tedbirlerin vergi mükelleflerinin, verilendirilmesi gereken iş ve işlemler ile gelirlerin tespitine ve vergi kaçakçılığının ortaya çıkarılmasına önemli ölçüde katkı yapma potansiyelinin bulunduğunu, ancak ülkemizde bu potansiyelden yeterince yararlanılmadığını göstermiştir.
  • Article
    Recovery of Myocardial Functions After Kidney Transplantation in Patients With Heart Failure Due To Uremic Cardiomyopathy
    (Kare Publ, 2025) Ozates, Yelda Saltan; Odabasi, Ahmet Yener; Yildiz, Ufuk; Albayrak, Duygu Genc; Inan, Duygu; Bas, Serap; Tekkesin, Ahmet Ilker
    Objective: Although left ventricular hypertrophy frequently accompanies end-stage renal disease, heart failure (HF) with reduced ejection fraction (EF) is also observed in a subset of patients. In those patients kidney transplantation (KT) is generally avoided due to an increased risk of mortality in addition to the risks associated with HF. This prospective study was designed to follow patients with HF who were being prepared for KT. Methods: Twenty-five patients with HF due to uremic cardiomyopathy (UC) who had suitable donors (Group 1), 22 patients with HF who could not undergo KT due to a lack of kidney donors (Group 3), and 25 KT candidates with normal ventricular function (Group 2) were included in the study. Left ventricular ejection fraction (LVEF), left atrial diameter (LAD), mitral annular systolic velocity (Sm), left ventricular global longitudinal strain (GLS), and left ventricular mass index (LVMI) values were recorded across four sessions, from pre-transplant to six months post-transplantation. Endomyocardial biopsy was performed for detailed examination of the myocardium in patients in Group 1 and Group 3, and cardiac magnetic resonance imaging (MRI) was performed in all three groups before transplantation. Results: In Group 1, LVEF, Sm, and left ventricular global longitudinal strain (LV-GLS) increased significantly, while LAD and LVMI decreased, all reaching normal levels. In contrast, no changes were observed in Group 3 and Group 2 (P < 0.01 for LVEF, P < 0.01 for GLS, P < 0.01 for LAD, and P < 0.01 for LVMI measurements). No differences in cardiac MRI and biopsy findings were observed between Group 1 and Group 3. Conclusion: Since myocardial function improved significantly and normalized in all patients with it has been demonstrated that UC can be reversible when treated with KT.
  • Article
    Citation - Scopus: 1
    Opportunities and Challenges of AI in Educational Assessment
    (Assoc Measurement & Evaluation Education & Psychology, 2024) Sahın, Alper; Thompson, Nathan; Ercikan, Kadriye
    In the past few years, as artificial intelligence (AI) and large language models (LLM) have rapidly entered our lives, we have witnessed groundbreaking innovations across numerous fields. The rapid pace of these changes has been met with excitement by some and apprehension by others. However, we all agree that they have made tremendous contributions so far and their contributions in the future will reshape our existence. The field of educational assessment is no exception. With this in mind, we issued a call for a special issue themed “Opportunities and Challenges of AI in Educational Assessment.” which finally included seven distinguished articles on subthemes of fair and responsible use of AI in educational assessment, learning analytics, automated scoring, and real-life examples of AI and LLM.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Cannabinoid Receptor Ligands Modulate Fibrosis and Inflammation in Idiopathic Pulmonary Fibrosis: a Preliminary Study
    (Tubitak Scientific & Technological Research Council Turkey, 2024) Kose, Sevil; Onen, Selin; Gizer, Merve; Boduroglu, Esin; Gonullu, Ugur; Korkusuz, Petek
    Background/aim: No specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF) exists. Therefore, new antiinflammatory therapeutic strategies are needed. Cannabinoids (CBs), known for their inflammation-modulating and antifibrotic effects, may be potential medication candidates for treating IPF. We aim to evaluate the inflammation-modulating and antifibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide-stimulated normal human lung fibroblast, epithelial cells, IPF fibroblast cells, and monocytes. Materials and methods: We detected CBRs in normal human lung fibroblasts (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry. We determined TGF-(31, IL-8, and TNF-alpha inflammatory cytokines in the LL24, LL29, A549, and THP-1 cell culture supernatants on days 1 and 5 by ELISA. We evaluated the cell viability in LL24, LL29, and A549 cells on days 1, 3, and 5 spectrophotometrically and detected collagen Type I (ColI) production in the LL24 and LL29 cell culture supernatants on days 1, 3, and 5 by ELISA. Results: LL24, LL29, A549, and THP-1 cells exhibited CB1 (CB1R) and CB2 (CB2R) receptors. CB1R and CB2R agonists WIN55,2122 and JWH015 inhibited fibroblastic and epithelial cell proliferation on day 5. TGF-(31 and TNF-alpha release increased, while IL-8 release decreased in LL24, LL29, A549, and THP-1 cells in response to the administration of WIN55,212-2 and JWH015 at a 10-2 mM concentration. CB1R and CB2R antagonists AM251 and AM630 did not block agonistic responses, suggesting a nonclassical CBRmediated pathway. CB2R agonist JWH015 decreased ColI expression in IPF lung fibroblasts LL29 on day 3. Conclusion: These results suggest that CB signaling regulates the progression of pulmonary inflammation and fibrosis via CBR activation. This may offer a potential pharmacological tool for developing antifibrosis therapies.