Atılım Üniversitesi / Atılım University

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Kontrollü ilaç salımı için aljinat nanotaşıyıcı sistemler: in vitro etkilerinin incelenmesi
The-use-of nano-sized drug carriers (Nano-Carriers, NC) to increase the therapeutic effectiveness of drugs recently received great attention and emerged as a new research area. In this approach, the studies were revealed that, the drug loaded NCs increase the therapeutic efficiency while successfully reducing the systemic toxicity, although the previously recommended drug dose for patients decreases. On-the-other hand, results of the clinical applications of liposomal carriers, as micro-drug-carrier system, shown that the decrease in dosage, for the drugs in routine use, also decreases the-production of pharmaceutical raw materials and considerably reduces the-industrial energy consumption. Therefore, therapeutic applications of NCs can provide benefits in many aspects, including the improvement in patient’s life expectancy and quality; the-reduction-in the treatment and production costs reflected to patients, healthcare-providers and pharmaceutical industry. while NC-based applications emerged as-an-attractive research area, the-serious contributions -expected- are advancements in pharmaceutical and chemical industry-along-with the economic development of-countries. NCs-are-generally produced-in-bio-degradable-and nondegradable- forms. Among those, polymeric NCs, such as alginate-NC (ANC), has more significant therapeutic-features such as bio-compatibility-and-degradability. Particularly, the metal ions used as cross-binders (CB) for ANT production is also an advantage since the toxicity of metal ions is low compared to organic CBs. However, in the literature no comparative study is available for therapeutic activities and toxicities of ANTs produced with different metal CBs. Therefore, in this study, the aim is to produce highly bio-compatible- ANC with different methods and cross-binders, and-perform-comparative in-vitro evaluation for ANC-mediated enhancement of drug-release capabilities, therapeutic dose and efficacy of ANTs loaded-with-conventional and novel-therapeutics.
Kükürtten Bağlanan Liganlar İçeren Yeni Platin Mavisi Komplekslerinin sentezi, Elektrokimyasal Karakterizasyonu ve Antitümör Etkileri
Chemical Engineering
Platinum blues have generated substantial interest not only due to their activity but also for their brillant colors. The compounds involving various amide and pyrimidine ligands are intense blue, blue-green or purple. A variety of the structures that contain nitrogen, N, and oxygen, O, have been assigned to the platinum blues, however, no platinum blues compound containing sulphur, S and nitrogen has been reported. Apart from the above mentioned complexes, some platinum pyrimidine blues complexes having antitumor activity was also be studied, recently. The main objective of the proposed project is to senthesize the platinum blues compounds by using sulphur donor ligands, 2-aminothiophenol and 3-aminothiophenol at the first time. Analysis of the products will be performed by UV-Vis, IR, ESR, ESCA, 1H-NMR, 13C-NMR ve 195Pt-NMR methods and the crystal structures will be identified by using X-ray diffraction spectrophotometer. The change in the DNA (Deoxyribonucleic acid: gene) conformation that is generated by the interaction of the complexes will be determined by electrophoresis and the electrochemical methods. Electrochemical behaviour of the complexes will be studied by cyclic voltammetry (CV) and the constant potental electrolyses of the complexes will be carried out at the peak potentials. The changes in the electronic absorption spectra of the complexes will be followed in situ by UV-vis spectrophotometer during the electrolysis in order to identify the electrolysis products and possible reaction intermediates. The number of the electrons that are transferred during the electrolysis will be counted by coulommetric methods and the presence of the unpaired electrons or the radicals will be proved by electron spin resonance spectroscopy. Moreover, the charges pf the platinum ions present in the complex structure will be determined by ESCA and the structural identification of the complexes will also be performed by NMR (nuclear magnetic resonans) spectra besides X-ray diffraction spectrophotometer.
Oksim Türevi Ligandlar İçeren Yeni Platin(II) Komplekslerinin Sentezi, Elektrokimyasal Karakterizasyonu ve DNA’ya Bağlanma Aktivitesi
Chemical Engineering
The interest in platinum based antitumor drugs has been started in 1960’s with the serendipitous discovery by Rosenberg of the inhibition of cell division by platinum complexes. Cisplatin, cisdiamminedichloroplatinum(II), was approved by United Sates FDA in 1978 as an antitumor drug. It most effective against testicular and ovarian cancer. Despite the success of cisplatin chemotherapy, it has several serious side effects such as nausea, vomiting, nephrotoxicity, ototoxicity, neuropathy and myelosuppression. The other main reason for a failure of cisplatin chemotherapy is resistance of tumors to the drug. The resistance can be intrinsic or acquired and limits the applicability of cisplatin. Due to all of these reasons, the design and synthesis of more active, less toxic and orally active platinum drugs have been prompted in order to reduce severe side effects, to overcome drug resistance and to improve the patient’s quality of life. The main aim of this study is to synthesize novel platinum complexes with variety of ligands of oximes as potential anticancer drug leads providing better efficacy with low tissue resistance compared to cisplatin. Analysis of the products will be performed by UV-Vis, IR, ESR, ESCA, 1H-NMR, 13C-NMR ve 195Pt-NMR methods and the crystal structures will be identified by using X-ray diffraction spectrophotometer. The change in the DNA (Deoxyribonucleic acid: gene) conformation that is generated by the interaction (e.g groove binding, intercalation and H-bonding) of the complexes will be determined by electrophoresis with some spectroscopic and electrochemical methods.. Electrochemical behaviour of the complexes will be studied by cyclic voltammetry (CV) and the constant potental electrolyses of the complexes will be carried out at the peak potentials. The changes in the electronic absorption spectra of the complexes will be followed in situ by UV-vis spectrophotometer during the electrolysis in order to identify the electrolysis products and possible reaction intermediates. The number of the electrons that are transferred during the electrolysis will be counted by coulommetric methods and the presence of the unpaired electrons or the radicals will be proved by electron spin resonance spectroscopy. Moreover, the charges of the platinum ions present in the complex structure will be determined by ESCA and the structural identification of the complexes will also be performed by NMR (nuclear magnetic resonans) spectra besides X-ray diffraction spectrophotometer.

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