Kükürtten Bağlanan Liganlar İçeren Yeni Platin Mavisi Komplekslerinin sentezi, Elektrokimyasal Karakterizasyonu ve Antitümör Etkileri

Platinum blues have generated substantial interest not only due to their activity but also for their brillant colors. The compounds involving various amide and pyrimidine ligands are intense blue, blue-green or purple. A variety of the structures that contain nitrogen, N, and oxygen, O, have been assigned to the platinum blues, however, no platinum blues compound containing sulphur, S and nitrogen has been reported. Apart from the above mentioned complexes, some platinum pyrimidine blues complexes having antitumor activity was also be studied, recently. The main objective of the proposed project is to senthesize the platinum blues compounds by using sulphur donor ligands, 2-aminothiophenol and 3-aminothiophenol at the first time. Analysis of the products will be performed by UV-Vis, IR, ESR, ESCA, 1H-NMR, 13C-NMR ve 195Pt-NMR methods and the crystal structures will be identified by using X-ray diffraction spectrophotometer. The change in the DNA (Deoxyribonucleic acid: gene) conformation that is generated by the interaction of the complexes will be determined by electrophoresis and the electrochemical methods. Electrochemical behaviour of the complexes will be studied by cyclic voltammetry (CV) and the constant potental electrolyses of the complexes will be carried out at the peak potentials. The changes in the electronic absorption spectra of the complexes will be followed in situ by UV-vis spectrophotometer during the electrolysis in order to identify the electrolysis products and possible reaction intermediates. The number of the electrons that are transferred during the electrolysis will be counted by coulommetric methods and the presence of the unpaired electrons or the radicals will be proved by electron spin resonance spectroscopy. Moreover, the charges pf the platinum ions present in the complex structure will be determined by ESCA and the structural identification of the complexes will also be performed by NMR (nuclear magnetic resonans) spectra besides X-ray diffraction spectrophotometer.