Özalp Yaman, Şeniz

Profile URL
https://hdl.handle.net/20.500.14411/6676
Name Variants
Ozalp Yaman,Ş. Ozalp Yaman, Seniz Ş.,Özalp Yaman S.,Ozalp Yaman Şeniz Özalp Yaman O., Seniz O. Y. Seniz Ozalp Yaman,S. Ozalp Yaman,Seniz O.,Seniz Seniz, Ozalp Yaman Şeniz, Özalp Yaman Ö., Şeniz Ö.Y.Şeniz Ö. Y. Şeniz Özalp Yaman Ş. Özalp Yaman,Ş. S., Ozalp Yaman Ş., Özalp Yaman Ö.,Şeniz Özalp Yaman, Şeniz Ozalp-Yaman, Seniz Yaman, Seniz-Ozalp Yaman, Şeniz Özalp Özalp-Yaman, S Oezalp-Yaman, Seniz Özalp-Yaman,Ş. Yaman,Ş.Ö.
Job Title
Profesör Doktor
Email Address
seniz.ozalpyaman@atilim.edu.tr
Main Affiliation
Chemical Engineering
Status
Website
ORCID ID
0000-0002-4166-0529
Scopus Author ID
56054555600
Turkish CoHE Profile ID
Google Scholar ID
5FyBmLkAAAAJ
WoS Researcher ID
No research topics data found.

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
14
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QUALITY EDUCATION4
QUALITY EDUCATION
0
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GENDER EQUALITY5
GENDER EQUALITY
0
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
4
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
1
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
2
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REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
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SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
1
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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CLIMATE ACTION13
CLIMATE ACTION
0
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LIFE BELOW WATER14
LIFE BELOW WATER
0
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LIFE ON LAND15
LIFE ON LAND
0
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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PARTNERSHIPS FOR THE GOALS17
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0
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Documents

24

Citations

573

h-index

11

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No records found in other affiliations.
Scholarly Output

40

Articles

26

Views / Downloads

63/178

Supervised MSc Theses

8

Supervised PhD Theses

5

WoS Citation Count

483

Scopus Citation Count

529

Patents

0

Projects

4

WoS Citations per Publication

12.08

Scopus Citations per Publication

13.23

Open Access Source

5

Supervised Theses

13

JournalCount
Polyhedron5
Journal of Molecular Structure3
Chemistry – A European Journal2
Electrochimica Acta2
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences2
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Now showing 1 - 10 of 40
  • Doctoral Thesis
    Organik Çözücülerle Karbonil Sülfit Yakalamanın Teorik Olarak İncelenmesi
    (2021) Abduesslam, Mahmoud; Yaman, Şeniz Özalp; Kayı, Hakan
    Kimya mühendisleri, endüstriyel gazlardaki karbonil sülfitin (COS) varlığına odaklanırlar ve ayrıca sıvılaştırılmış petrol gazında COS'nin doğal oluşumlarını dikkate alırlar. Çevresel düzenlemelere uymak ve gaz dağıtım endüstrilerinin katı çevresel gereksinimlerini karşılamak için gaz akışlarındaki zehirli ve aşındırıcı özelliklere sahip tüm safsızlıklar temizlenmelidir. Reaktif soğurma, asit gazlarını gidermenin en güvenilir yollarından biri olarak kabul edildiğinden, aminler ve alkol karışımları kullanılarak asitleri gidermek için tipik olarak kullanılan bir tekniktir. Bu çalışmada, organik sıvı karışımları kullanılarak ωB97X-D3/6-311++G(d,p) teori düzeyinde yoğunluk fonksiyonel teorisi (DFT) hesaplamaları kullanılarak COS'nin yakalanması araştırılmıştır. Bu karışımlar, aminlerden, 1,8-diazabisiklo[5.4.0]undek-7-en (DBU), 1,5-diazabisiklo[4.3.0]non-5-en (DBN) ve 2-tert-bütil-1,1,3,3-tetrametilguanidin (BTMG) and 1, 5, 7-triazabicyclo [4.4.0] dec-5-ene (TBD)'den oluşmakta ve ayrıca bir dizi lineer alkol, yani metanol, etanol, 1-propanol, 1-butanol, 1-pentanol ve 1-hekzanol içermektedir. Çalışma boyunca, COS'un yakalanmasında 4 tip amin ile 6 tip alkol için modifiye edilmiş tek basamaklı bir termoleküler tepkime mekanizması incelenmiştir. Toplamda on sekiz farklı sistem araştırılmış ve önerilen COS yakalama tepkimelerinin termodinamiği ve kinetiği ile birlikte yapısal özellikleri ayrıntılı olarak ortaya konulmuştur. Sonuçlar, önerilen termoleküler tepkime mekanizmalarının test edilen 18 farklı sistem için termodinamik olarak uygulanabilir olduğunu ve BTMG ile metanolden oluşan organik sıvı kombinasyonunun, COS yakalamada en düşük enerji bariyeri ve en yüksek tepkime hızı ile sonuçlandığını gösterdi.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 6
    A platinum blue complex exerts its cytotoxic activity via DNA damage and induces apoptosis in cancer cells
    (Wiley, 2017) Adiguzel, Zelal; Ozalp-Yaman, Seniz; Celik, Gokalp; Salem, Safia; Bagci-Onder, Tugba; Senbabaoglu, Filiz; Acilan, Ceyda
    Here, we describe the characteristics of a Pt-blue complex [Pt-4(2-atp)(8)(H2O)(OH)] (2-atp: 2-aminothiophenol) as a prodrug for its DNA-binding properties and its use in cancer therapy. The nature of the interaction between the Pt-blue complex and DNA was evaluated based on spectroscopic measurements, the electronic absorption spectra, thermal behavior, viscosity, fluorometric titration, and agarose gel electrophoresis. Our results suggested that the compound was able to partially intercalate DNA and appeared to induce both single- and double-stranded breaks (DBS) on DNA in vitro, but no DSBs in cells. The ability of the compound to induce DNA damage was dependent on reactive oxygen species (ROS) in vitro. There was also elevated formation of ROS and SOD expression in response to drug treatment in cell culture. The complex was found to be more cytotoxic to cancer cells in comparison with noncancer controls using WST-1 assay. The mean of cell death was determined to be apoptosis as assessed via biochemical, morphological, and molecular observations, including DNA condensation/fragmentation analysis, live cell imaging microscopy, TUNEL analyses, and increase in the levels of pro-apoptotic genes such as Bag3, Bak, Bik, Bmf, and Hrk. Hence, the Pt-blue complex under study grants premise for further studies.
  • Doctoral Thesis
    Moleküler Modelleme Yaklaşımını Kullanarak Kanser Tümör Tedavisi için Piridil Tip Ligantları İçeren Platin ve Paladyum Komplekslerinin Tasarımı
    (2018) El-hag, Rabıa Hadı Mohamed; Kayı, Hakan; Yaman, Şeniz Özalp
    Geçen yüzyılın ortasında, bir cisplatin bileşiğinin keşfinden sonra, bu bileşik birkaç farklı kanser tipinin tedavisinde kullanılan en önemli kimyasal bileşiklerden biri haline gelmiştir. Ancak bu bileşiğin kanser hücrelerini öldürme ve yok etme yeteneğine rağmen, neden olduğu yan etkilere ek olarak birkaç kanser türünü tedavi edememekte, bu da bilim adamlarının daha etkili ve yan etkileri olmayan başka bileşikleri araştırmalarına yol açmaktadır. Keşfedilen ilaçların çoğunun, kanserlere karşı etkinliklerinin çok az olduğu gösterilmiştir. Elde ettiğimiz teknikler ve ilerlemelere ve kendini savaşmaya adamış sayısız doktor olmasına rağmen, kanser gerçek bir tehdit, çaresiz bir hastalıktır, ancak yine de umut vardır. Bilim adamları 50 yıl önce imkansız görünen tedavilerle ortaya çıktılar ve tedavi edilemez denen bazı kanserlerden kurtulmayı başardılar. Mükemmel sonuçlar elde etmek için tedavi araçlarını farklı şekillerde kullanmaya başladık. Kanser hala korkutucu olsa da ve her zaman öyle kalabilir olsa da, kansere karşı attığımız adımlar tedaviyi sadece mümkün kılmakla kalmayıp aynı zamanda erişilebilir hale de getirmiştir. Önceki çalışmalardan, platin ve paladyum bileşiklerinin, uygun ligand, iyi geometri ve aktif çıkış grubu gibi birçok parametreyi hesaba katarsak, kanser hücrelerine karşı en etkili bileşikler olduğu sonucuna varılabilir. Buradan, araştırmalarla alternatif kanser tedavisi bileşikleri olarak bazı platin ve paladyum bileşiklerini tasarlamaya ve geliştirmeye başlandı. Bu araştırmada, on altı platin ve paladyum bileşiği iki farklı tipte ligand ile tasarlandı. Yeni bileşikler, yoğunluk fonksiyonel teorisi, DFT, kullanılarak teorik olarak tasarlanmış ve test edilmiştir. FTIR, NMR ve UV-vis gibi bu komplekslerin spektroskopik özellikleri ve geometri optimizasyonları B3LYP/LANL2DZ teori seviyesinde ve Gaussian programı kullanılarak hesaplanmıştır. Bu bileşiklerin iki tip DNA ile etkileşim süreci daha sonra Docking programı kullanılarak simüle edilmiştir ve komplekslerimizin cisplatinden (kovalent, elektrostatik, oluk ve interkalasyon) farklı mekanizmalarla ve belkide cisplatinin yan etkilerinin üstesinden gelebileceğine yol açacak şekilde DNA ile etkileştiğini ortaya koymuştur. Bu bileşiklerin teorik sonuçları oldukça umut vericidir. Bu bileşiklerin bazıları canlı hücreler üzerinde deneysel olarak test edilmiş ve çeşitli kanser türlerine karşı etkili olduğu kanıtlanmıştır. Deneysel ve teorik sonuçlar arasında iyi derecede bir uyumluluk gözlenmiştir. Söz konusu yeni komplekslerin, bu kompleksler hakkında daha ileri çalışmalar için umut verici sonuçları vardır.
  • Article
    Carbon Dots Derived from Soft and Hard Biomass via Hydrothermal and Probe-Type Sonochemical Routes: A Comparative Study
    (Elsevier B.V., 2026) Gümrah, Özlem; Bozkurt, Pınar Acar; Elçi, Zeynep Bilge; Yaman, Şeniz Özalp
    Carbon dots (CDs) were synthesized from nettle leaves and waste walnut shells using hydrothermal and probe-type sonochemical methods. The samples were comprehensively characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Raman spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), X-ray photoelectron spectroscopy (XPS), zeta potential measurements, and elemental analysis. The results revealed that all samples consisted predominantly of amorphous and defective carbon structures with limited sp² domains. Among the synthesized samples, hydrothermally prepared nettle-derived CDs (NLHtc-CDs) exhibited the highest fluorescence quantum yield, which can be attributed to the relatively higher nitrogen content of the nettle biomass. Morphological analyses indicated that the probe-type sonochemical route favored the formation of more homogeneous carbon nanostructures for lignin-rich, hard biomass such as walnut shells (WSScc-CDs), whereas the hydrothermal method resulted in more uniform CDs for softer biomass such as nettle leaves. Under UV irradiation, the dispersions displayed distinct photoluminescence emissions: orange emission for hydrothermally synthesized nettle- and walnut-derived CDs (NLHtc-CDs and WSHtc-CDs), green emission for sonochemically synthesized nettle-derived CDs, and yellow emission for sonochemically synthesized walnut-shell-derived CDs. These observations highlight the dominant influence of precursor composition and surface chemistry on the optical properties of the CDs. Overall, the findings suggest that the precursor biomass composition may play an important role in determining the structural and optical characteristics of biomass-derived carbon dots and may have a stronger influence than the synthesis route under the investigated conditions. © 2026 Elsevier B.V.
  • Master Thesis
    2-aminotiyofenol İçeren Platin Mavisi Kompleksinin Dna Etkileşimi ve Sitotoksisitesi
    (2017) Salem, Safıa; Yaman, Şeniz Özalp
    Cis platinin keşfinden bu yana, metal içeren ajanlar potansiyel birer antikanser ilacı olarak araştırmacıların ilgisini çekmektedir. Bu güne kadar cis platinin toksik etkilerini ve cis platin direncini azaltmak için birçok ilaç sentezlenmiştir. Bu bileşiklerden bir tanesi de 'platin mavisi' olarak bilinen, toksisitesi cis platine göre daha düşük ve antikanser özelliği yüksek olan farklı bir platin kompleksi sınıfıdır. Bu çalışmada, [Pt4(2-atp)8(H2O)(OH)] (2-atp: 2- aminotiyofenol) formülüyle gösterilen yeni platin mavisi kompleksinin DNA'ya bağlanma kabiliyeti araştırılmıştır. Pt mavisi ve DNA arasındaki etkileşim türünün belirlenebilmesi için spektroskopik ölçümler yapılmış, platin kompleksinin varlığında DNA çözeltisinin UV-titrasyon, termal bozunma, viskozite değişim ve florometrik titrasyon deneyleri tamamlanmıştır. Sonuçlar platin mavisi bileşiğinin DNA'ya kısmen interkaltif olarak bağlandığını ve antikanser özelliği gösterdiğini kanıtlamıştır.
  • Article
    How Can We Get Benefits of Computer-Based Testing in Engineering Education?
    (Computer Applications in Engineering Education, 2010) Çağıltay, Nergiz; Özalp Yaman, Şeniz
    Using computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil (P&P) and computer-based test (CBT) environments. Additionally, these studies fail to address the engineering domain. Our main assumption is that, if we could define the confounding factors to satisfy that these two versions of the tests provide equivalent results, then especially in the first year courses of the engineering education programs, we could get several benefits of the CBT environments. Accordingly, in this study, students' performance o different test modes waws evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that there is no significant performance difference between P&P and CBT. By comparing results with the previous studies, this study concludes that personal characteristics of test talers, the features of CBT systems, and the test content are all possible confounding factors when comparing test modes anf need to be considered by the implementers. The results of this study show that once these factors are controlled, students' performance on CBTs and P&P tests in chemistry courses will not vary. This finding is encourging the educators to get benefits of CBTs without any affect on students' performance.
  • Article
    Citation - WoS: 14
    Citation - Scopus: 19
    Electrochemistry of nickel(II) complexes with <i>N</i>,<i>N</i>'-bis(3,5-di-<i>tert</i>-butylsalicylidene)polymethylenediamines
    (Pergamon-elsevier Science Ltd, 2005) Özalp-Yaman, S; Kasumov, VT; Önal, AM
    The electrochemical oxidation of several N,N'-polymethylenebis(3,5-di-tert- butylsalicylaldiminato)nickel(II) complexes, Ni(L-x), has been studied by cyclic voltammetry and in situ UV-Vis spectroscopy in DMF Cyclic voltammograms of Ni(L-x) (x = 1-4) complexes displayed two-step oxidation processes under nitrogen gas atmosphere. The first oxidation peak potentials of all the Ni(II) complexes corresponds to the reversible one-electron oxidation process of the metal center, yielding Ni(III) species. EPR spectrum of the electrolysis solution was recorded after one electron transfer at liquid nitrogen temperature also confirms the formation of [Ni-III (L-3)](+) species (g(x) > g(y) > g(z)) with a (2)A(1)(d(z)(2))(1) ground state. Upon addition of pyridine to one electron oxidised solutions a new penta coordinated species, [Ni-III(L-3)Py](+) (g(perpendicular to) > g(parallel to), a(parallel to)(N-14) = 8 G), was produced. The second oxidation peak of the complexes was assigned as the ligand based oxidation, generating a coordinated phenoxy radical species. (c) 2005 Elsevier Ltd. All rights reserved.
  • Article
    Citation - WoS: 16
    Citation - Scopus: 20
    Concise Synthesis, Electrochemistry and Spectroelectrochemistry of Phthalocyanines Having Triazole Functionality
    (Pergamon-elsevier Science Ltd, 2014) Karaca, Huseyin; Sezer, Serdar; Ozalp-Yaman, Seniz; Tanyeli, Cihangir
    The synthesis of novel metallophthalocyanines (M = Zn, Ni) bearing substituted benzyl protected 1,2,3-triazole moieties at peripheral positions is described for the first time via direct cyclotetramerization. These complexes have been characterized by a combination of FT-IR, H-1 NMR, HRMS and UVVis spectroscopy techniques and all the new compounds are highly soluble in most common organic solvents. In addition, the electrochemical and electrochromic behaviors of the complexes are investigated. Cyclic voltammetry and differential pulse voltammetry measurements demonstrate ligand base oxidations and reductions for both the Zn(II) and Ni(II) phthalocyanines by the transfer of one electron in each electrochemical step. The redox couples are identified in situ by monitoring the electronic absorption spectral changes during the electrolysis.
  • Article
    Citation - WoS: 13
    Electrochemical and Quantum Chemical Studies on Mitomycin and Adriamycin
    (Elsevier, 2003) Özalp-Yaman, S; Önal, AM; Türker, L
    In-situ spectroelectrochemical redox behaviour of two prominent chemotherapeutic agents, mitomycin and adriamycin were studied at constant potential. AM 1 (UHF) type quantum chemical calculations on the neutral as well as radical anion and cation forms of mitomycin and adriamycin were performed. (C) 2003 Elsevier Science B.V. All rights reserved.
  • Article
    Citation - WoS: 12
    Citation - Scopus: 13
    Novel Pt(ii) Complexes Containing Pyrrole Oxime, Synthesis, Characterization and Dna Binding Studies
    (Elsevier, 2014) Erdogan, Deniz Altunoz; Ozalp-Yaman, Seniz
    Since the discovery of anticancer activity and subsequent clinical success of cisplatin (cis-[PtCl2(NH3)(2)]), platinum-based compounds have since been widely synthesized and studied as potential chemotherapeutic agents. In this sense, three novel nuclease active Pt(II) complexes with general formula; [Pt(NH3)CI(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) in which L is 1-H-pyrrole-2-carbaldehyde oxime were synthesized. Characterization of complexes was performed by elemental analysis, FT-IR, H-1 NMR and mass spectroscopy measurements. Interaction of complexes (1-3) with calf thymus deoxyribonucleic acid (ct-DNA) was investigated by using electrochemical, spectroelectrochemical methods and cleavage studies. The hyperchromic change in the electronic absorption spectrum of the Pt(II) complexes indicates an electrostatic interaction between the complexes and ct-DNA. Binding constant values between 4.42 x 10(3) and 5.09 x 10(3) M-1 and binding side size values between 2 and 3 base pairs were determined from cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies. (C) 2014 Elsevier B.V. All rights reserved.