Özalp Yaman, Şeniz
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Name Variants
Ozalp Yaman,Ş.
Ozalp Yaman, Seniz
Ş.,Özalp Yaman
S.,Ozalp Yaman
Şeniz Özalp Yaman
O., Seniz
O. Y. Seniz
Ozalp Yaman,S.
Ozalp Yaman,Seniz
O.,Seniz
Seniz, Ozalp Yaman
Şeniz, Özalp Yaman
Ö., Şeniz
Ö.Y.Şeniz
Ö. Y. Şeniz
Özalp Yaman Ş.
Özalp Yaman,Ş.
S., Ozalp Yaman
Ş., Özalp Yaman
Ö.,Şeniz
Özalp Yaman, Şeniz
Ozalp-Yaman, Seniz
Yaman, Seniz-Ozalp
Yaman, Şeniz Özalp
Özalp-Yaman, S
Oezalp-Yaman, Seniz
Özalp-Yaman,Ş.
Yaman,Ş.Ö.
Ozalp Yaman, Seniz
Ş.,Özalp Yaman
S.,Ozalp Yaman
Şeniz Özalp Yaman
O., Seniz
O. Y. Seniz
Ozalp Yaman,S.
Ozalp Yaman,Seniz
O.,Seniz
Seniz, Ozalp Yaman
Şeniz, Özalp Yaman
Ö., Şeniz
Ö.Y.Şeniz
Ö. Y. Şeniz
Özalp Yaman Ş.
Özalp Yaman,Ş.
S., Ozalp Yaman
Ş., Özalp Yaman
Ö.,Şeniz
Özalp Yaman, Şeniz
Ozalp-Yaman, Seniz
Yaman, Seniz-Ozalp
Yaman, Şeniz Özalp
Özalp-Yaman, S
Oezalp-Yaman, Seniz
Özalp-Yaman,Ş.
Yaman,Ş.Ö.
Job Title
Profesör Doktor
Email Address
seniz.ozalpyaman@atilim.edu.tr
Main Affiliation
Chemical Engineering
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
37
Articles
25
Citation Count
449
Supervised Theses
10
36 results
Scholarly Output Search Results
Now showing 1 - 10 of 36
Article Citation - WoS: 35Citation - Scopus: 41Synthesis, Spectroscopy and Electrochemical Behaviors of Nickel(ii) Complexes With Tetradentate Shiff Bases Derived From 3,5-bu2t<(Pergamon-elsevier Science Ltd, 2005) Kasumov, VT; Özalp-Yaman, S; Tas, E; Chemical EngineeringNickel(II) complexes of a series of N,N'-polymethylenebis(3,5-Bu'(2)-salicylaidimine) ligands containing 2,4-di-Bu'(2)-phenol arms, NiLx, were synthesized and their spectroscopic and redox properties were examined. The UV-vis, H-1 NMR spectroscopic and magnetic results indicate that complexes NiL1-NiL4 unlike NiL5 and NiL6 have a square-planar structure in the solid state and in solution. Cyclic voltammograms of NiLx (x= 1-4) complexes displayed two-step oxidation processes. The first oxidation peak potentials of all Ni(II) complexes corresponds to the reversible one-electron oxidation process of the metal center, yielding Ni(III) species. The second oxidation peak of the complexes was assigned as the ligand based oxidation generating a coordinated phenoxyl radical species. (c) 2005 Elsevier B.V. All rights reserved.Article Citation - WoS: 6Citation - Scopus: 4A platinum blue complex exerts its cytotoxic activity via DNA damage and induces apoptosis in cancer cells(Wiley, 2017) Adiguzel, Zelal; Ozalp-Yaman, Seniz; Celik, Gokalp; Salem, Safia; Bagci-Onder, Tugba; Senbabaoglu, Filiz; Acilan, Ceyda; Chemical EngineeringHere, we describe the characteristics of a Pt-blue complex [Pt-4(2-atp)(8)(H2O)(OH)] (2-atp: 2-aminothiophenol) as a prodrug for its DNA-binding properties and its use in cancer therapy. The nature of the interaction between the Pt-blue complex and DNA was evaluated based on spectroscopic measurements, the electronic absorption spectra, thermal behavior, viscosity, fluorometric titration, and agarose gel electrophoresis. Our results suggested that the compound was able to partially intercalate DNA and appeared to induce both single- and double-stranded breaks (DBS) on DNA in vitro, but no DSBs in cells. The ability of the compound to induce DNA damage was dependent on reactive oxygen species (ROS) in vitro. There was also elevated formation of ROS and SOD expression in response to drug treatment in cell culture. The complex was found to be more cytotoxic to cancer cells in comparison with noncancer controls using WST-1 assay. The mean of cell death was determined to be apoptosis as assessed via biochemical, morphological, and molecular observations, including DNA condensation/fragmentation analysis, live cell imaging microscopy, TUNEL analyses, and increase in the levels of pro-apoptotic genes such as Bag3, Bak, Bik, Bmf, and Hrk. Hence, the Pt-blue complex under study grants premise for further studies.Article Citation - WoS: 13Citation - Scopus: 18Electrochemistry of nickel(II) complexes with N,N'-bis(3,5-di-tert-butylsalicylidene)polymethylenediamines(Pergamon-elsevier Science Ltd, 2005) Özalp-Yaman, S; Kasumov, VT; Önal, AM; Chemical EngineeringThe electrochemical oxidation of several N,N'-polymethylenebis(3,5-di-tert- butylsalicylaldiminato)nickel(II) complexes, Ni(L-x), has been studied by cyclic voltammetry and in situ UV-Vis spectroscopy in DMF Cyclic voltammograms of Ni(L-x) (x = 1-4) complexes displayed two-step oxidation processes under nitrogen gas atmosphere. The first oxidation peak potentials of all the Ni(II) complexes corresponds to the reversible one-electron oxidation process of the metal center, yielding Ni(III) species. EPR spectrum of the electrolysis solution was recorded after one electron transfer at liquid nitrogen temperature also confirms the formation of [Ni-III (L-3)](+) species (g(x) > g(y) > g(z)) with a (2)A(1)(d(z)(2))(1) ground state. Upon addition of pyridine to one electron oxidised solutions a new penta coordinated species, [Ni-III(L-3)Py](+) (g(perpendicular to) > g(parallel to), a(parallel to)(N-14) = 8 G), was produced. The second oxidation peak of the complexes was assigned as the ligand based oxidation, generating a coordinated phenoxy radical species. (c) 2005 Elsevier Ltd. All rights reserved.Article Citation - WoS: 15Citation - Scopus: 19Concise Synthesis, Electrochemistry and Spectroelectrochemistry of Phthalocyanines Having Triazole Functionality(Pergamon-elsevier Science Ltd, 2014) Karaca, Huseyin; Sezer, Serdar; Ozalp-Yaman, Seniz; Tanyeli, Cihangir; Chemical EngineeringThe synthesis of novel metallophthalocyanines (M = Zn, Ni) bearing substituted benzyl protected 1,2,3-triazole moieties at peripheral positions is described for the first time via direct cyclotetramerization. These complexes have been characterized by a combination of FT-IR, H-1 NMR, HRMS and UVVis spectroscopy techniques and all the new compounds are highly soluble in most common organic solvents. In addition, the electrochemical and electrochromic behaviors of the complexes are investigated. Cyclic voltammetry and differential pulse voltammetry measurements demonstrate ligand base oxidations and reductions for both the Zn(II) and Ni(II) phthalocyanines by the transfer of one electron in each electrochemical step. The redox couples are identified in situ by monitoring the electronic absorption spectral changes during the electrolysis.Article Citation - WoS: 13Electrochemical and Quantum Chemical Studies on Mitomycin and Adriamycin(Elsevier, 2003) Özalp-Yaman, S; Önal, AM; Türker, L; Chemical EngineeringIn-situ spectroelectrochemical redox behaviour of two prominent chemotherapeutic agents, mitomycin and adriamycin were studied at constant potential. AM 1 (UHF) type quantum chemical calculations on the neutral as well as radical anion and cation forms of mitomycin and adriamycin were performed. (C) 2003 Elsevier Science B.V. All rights reserved.Article Citation - WoS: 12Citation - Scopus: 13Novel Pt(ii) Complexes Containing Pyrrole Oxime, Synthesis, Characterization and Dna Binding Studies(Elsevier, 2014) Erdogan, Deniz Altunoz; Ozalp-Yaman, Seniz; Chemical EngineeringSince the discovery of anticancer activity and subsequent clinical success of cisplatin (cis-[PtCl2(NH3)(2)]), platinum-based compounds have since been widely synthesized and studied as potential chemotherapeutic agents. In this sense, three novel nuclease active Pt(II) complexes with general formula; [Pt(NH3)CI(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) in which L is 1-H-pyrrole-2-carbaldehyde oxime were synthesized. Characterization of complexes was performed by elemental analysis, FT-IR, H-1 NMR and mass spectroscopy measurements. Interaction of complexes (1-3) with calf thymus deoxyribonucleic acid (ct-DNA) was investigated by using electrochemical, spectroelectrochemical methods and cleavage studies. The hyperchromic change in the electronic absorption spectrum of the Pt(II) complexes indicates an electrostatic interaction between the complexes and ct-DNA. Binding constant values between 4.42 x 10(3) and 5.09 x 10(3) M-1 and binding side size values between 2 and 3 base pairs were determined from cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies. (C) 2014 Elsevier B.V. All rights reserved.Article Citation - WoS: 40Citation - Scopus: 47Platinated Copper(3-Clip Complexes as Effective Dna-Cleaving and Cytotoxic Agents(Wiley-v C H verlag Gmbh, 2008) Ozalp-Yaman, Seniz; de Hoog, Paul; Amadei, Giulio; Pitie, Marguerite; Gamez, Patrick; Dewelle, Janique; Reedijk, Jan; Chemical EngineeringThe synthesis and biological activity of three heteronuclear platinum-copper complexes based on 3-Clip-Phen are reported. These rigid complexes have been designed to alter the intrinsic mechanism of action of both the platinum moiety and the Cu(3-Clip-Phen) unit. The platinum centers of two of these complexes are coordinated to a 3-Clip-Phen moiety, an ammine ligand and two chlorides, which are either cis or trans to each other. The third complex comprises two 3-Clip-Phen units and two chloride ligands bound in a trans fashion to the platinum ion. DNA-cleavage experiments show that the complexes are highly efficient nuclease agents. In addition, a markedly difference in their aptitude to perform direct double-strand cleavage is observed, which appears to be strongly related to the ability of the platinum unit to coordinate to DNA. Indeed, complex 6 is unable to coordinate to DNA, which is reflected by its incapability to carry out double-strand breaks. Nonetheless, this complex exhibits efficient DNA-cleavage activity, and its cytotoxicity is high for several cell lines. Complex 6 shows better antiproliferate activity than both cisplatin and Cu(3-Clip-Phen) toward most cancer cell lines. Furthermore, the cytotoxicity observed for 1 is for most cell lines close to that of cisplatin, or even better. Cu(3-Clip-Phen) induces very low cytotoxic effects, but a marked migratory activity. Complex 6 presents DNA-cleavage properties comparable to the one of Cu(3-Clip-Phen), but it does not show any migratory activity. Interestingly, both Cu(3-Clip-Phen) and 6 induces vacuolisation processes in the cell in contrast to complex 1 and cisplatin. Thus, the four complexes cisplatin tested, Cu(3-Clip-Phen), I and 6 stimulate different cellular responses.Master Thesis 2-aminotiyofenol İçeren Platin Mavisi Kompleksinin Dna Etkileşimi ve Sitotoksisitesi(2017) Salem, Safıa; Yaman, Şeniz Özalp; Chemical EngineeringCis platinin keşfinden bu yana, metal içeren ajanlar potansiyel birer antikanser ilacı olarak araştırmacıların ilgisini çekmektedir. Bu güne kadar cis platinin toksik etkilerini ve cis platin direncini azaltmak için birçok ilaç sentezlenmiştir. Bu bileşiklerden bir tanesi de 'platin mavisi' olarak bilinen, toksisitesi cis platine göre daha düşük ve antikanser özelliği yüksek olan farklı bir platin kompleksi sınıfıdır. Bu çalışmada, [Pt4(2-atp)8(H2O)(OH)] (2-atp: 2- aminotiyofenol) formülüyle gösterilen yeni platin mavisi kompleksinin DNA'ya bağlanma kabiliyeti araştırılmıştır. Pt mavisi ve DNA arasındaki etkileşim türünün belirlenebilmesi için spektroskopik ölçümler yapılmış, platin kompleksinin varlığında DNA çözeltisinin UV-titrasyon, termal bozunma, viskozite değişim ve florometrik titrasyon deneyleri tamamlanmıştır. Sonuçlar platin mavisi bileşiğinin DNA'ya kısmen interkaltif olarak bağlandığını ve antikanser özelliği gösterdiğini kanıtlamıştır.Article How Can We Get Benefits of Computer-Based Testing in Engineering Education?(Computer Applications in Engineering Education, 2010) Çağıltay, Nergiz; Özalp Yaman, Şeniz; Chemical Engineering; Software EngineeringUsing computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil (P&P) and computer-based test (CBT) environments. Additionally, these studies fail to address the engineering domain. Our main assumption is that, if we could define the confounding factors to satisfy that these two versions of the tests provide equivalent results, then especially in the first year courses of the engineering education programs, we could get several benefits of the CBT environments. Accordingly, in this study, students' performance o different test modes waws evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that there is no significant performance difference between P&P and CBT. By comparing results with the previous studies, this study concludes that personal characteristics of test talers, the features of CBT systems, and the test content are all possible confounding factors when comparing test modes anf need to be considered by the implementers. The results of this study show that once these factors are controlled, students' performance on CBTs and P&P tests in chemistry courses will not vary. This finding is encourging the educators to get benefits of CBTs without any affect on students' performance.Article Citation - WoS: 14Citation - Scopus: 14How Can We Get Benefits of Computer-Based Testing in Engineering Education?(Wiley, 2013) Cagiltay, Nergiz; Yaman, Seniz-Ozalp; Software Engineering; Chemical EngineeringUsing computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil (P&P) and computer-based test (CBT) environments. Additionally, these studies fail to address the engineering domain. Our main assumption is that, if we could define the confounding factors to satisfy that these two versions of the tests provide equivalent results, then especially in the first year courses of the engineering education programs, we could get several benefits of the CBT environments. Accordingly, in this study, students' performance on different test modes was evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that there is no significant performance difference between P&P and CBT. By comparing results with the previous studies, this study concludes that personal characteristics of test takers, the features of CBT systems, and the test content are all possible confounding factors when comparing test modes and need to be considered by the implementers. The results of this study show that once these factors are controlled, students' performance on CBTs and P&P tests in chemistry courses will not vary. This finding is encouraging the educators to get benefits of CBTs without any affect on students' performance. (c) 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 21: 287293, 2013; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.20470
