Özalp Yaman, Şeniz

Profile URL
https://hdl.handle.net/20.500.14411/6676
Name Variants
Ozalp Yaman,Ş. Ozalp Yaman, Seniz Ş.,Özalp Yaman S.,Ozalp Yaman Şeniz Özalp Yaman O., Seniz O. Y. Seniz Ozalp Yaman,S. Ozalp Yaman,Seniz O.,Seniz Seniz, Ozalp Yaman Şeniz, Özalp Yaman Ö., Şeniz Ö.Y.Şeniz Ö. Y. Şeniz Özalp Yaman Ş. Özalp Yaman,Ş. S., Ozalp Yaman Ş., Özalp Yaman Ö.,Şeniz Özalp Yaman, Şeniz Ozalp-Yaman, Seniz Yaman, Seniz-Ozalp Yaman, Şeniz Özalp Özalp-Yaman, S Oezalp-Yaman, Seniz Özalp-Yaman,Ş. Yaman,Ş.Ö.
Job Title
Profesör Doktor
Email Address
seniz.ozalpyaman@atilim.edu.tr
Main Affiliation
Chemical Engineering
Status
Website
ORCID ID
0000-0002-4166-0529
Scopus Author ID
56054555600
Turkish CoHE Profile ID
Google Scholar ID
5FyBmLkAAAAJ
WoS Researcher ID

Research Topics

Domains
Health SciencesPhysical Sciences
Fields
MedicineChemistryMaterials ScienceEngineering
Subfields
OncologyElectrochemistryOrganic ChemistryElectronic, Optical and Magnetic MaterialsElectrical and Electronic Engineering
Specific Research Areas
Metal complexes synthesis and properties
Electrochemical Analysis and Applications
Ferrocene Chemistry and Applications
Magnetism in coordination complexes
Molecular Junctions and Nanostructures

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
14
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
0
Research Products
GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
4
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
1
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
2
Research Products
REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
Research Products
SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
1
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
CLIMATE ACTION13
CLIMATE ACTION
0
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
0
Research Products
LIFE ON LAND15
LIFE ON LAND
0
Research Products
PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
Research Products
Documents

24

Citations

576

h-index

11

Go to Scopus profile
This researcher does not have a WoS ID.

Publication Collaboration

Affiliation Name Count
Atilim University 24
Middle East Technical University 8
Leiden University 4
Koç University 4
Ankara University 4
1 / 5
Data obtained from OpenAlex
Scholarly Output

40

Articles

26

Views / Downloads

81/183

Supervised MSc Theses

8

Supervised PhD Theses

5

WoS Citation Count

486

Scopus Citation Count

532

Patents

0

Projects

4

WoS Citations per Publication

12.15

Scopus Citations per Publication

13.30

Open Access Source

5

Supervised Theses

13

JournalCount
Polyhedron5
Journal of Molecular Structure3
Chemistry – A European Journal2
Electrochimica Acta2
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences2
Current Page: 1 / 4

Scopus Quartile Distribution

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Scholarly Output Search Results

Now showing 1 - 10 of 40
  • Master Thesis
    2-aminotiyofenol İçeren Platin Mavisi Kompleksinin Dna Etkileşimi ve Sitotoksisitesi
    (2017) Salem, Safıa; Yaman, Şeniz Özalp
    Cis platinin keşfinden bu yana, metal içeren ajanlar potansiyel birer antikanser ilacı olarak araştırmacıların ilgisini çekmektedir. Bu güne kadar cis platinin toksik etkilerini ve cis platin direncini azaltmak için birçok ilaç sentezlenmiştir. Bu bileşiklerden bir tanesi de 'platin mavisi' olarak bilinen, toksisitesi cis platine göre daha düşük ve antikanser özelliği yüksek olan farklı bir platin kompleksi sınıfıdır. Bu çalışmada, [Pt4(2-atp)8(H2O)(OH)] (2-atp: 2- aminotiyofenol) formülüyle gösterilen yeni platin mavisi kompleksinin DNA'ya bağlanma kabiliyeti araştırılmıştır. Pt mavisi ve DNA arasındaki etkileşim türünün belirlenebilmesi için spektroskopik ölçümler yapılmış, platin kompleksinin varlığında DNA çözeltisinin UV-titrasyon, termal bozunma, viskozite değişim ve florometrik titrasyon deneyleri tamamlanmıştır. Sonuçlar platin mavisi bileşiğinin DNA'ya kısmen interkaltif olarak bağlandığını ve antikanser özelliği gösterdiğini kanıtlamıştır.
  • Article
    How Can We Get Benefits of Computer-Based Testing in Engineering Education?
    (Computer Applications in Engineering Education, 2010) Çağıltay, Nergiz; Özalp Yaman, Şeniz
    Using computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil (P&P) and computer-based test (CBT) environments. Additionally, these studies fail to address the engineering domain. Our main assumption is that, if we could define the confounding factors to satisfy that these two versions of the tests provide equivalent results, then especially in the first year courses of the engineering education programs, we could get several benefits of the CBT environments. Accordingly, in this study, students' performance o different test modes waws evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that there is no significant performance difference between P&P and CBT. By comparing results with the previous studies, this study concludes that personal characteristics of test talers, the features of CBT systems, and the test content are all possible confounding factors when comparing test modes anf need to be considered by the implementers. The results of this study show that once these factors are controlled, students' performance on CBTs and P&P tests in chemistry courses will not vary. This finding is encourging the educators to get benefits of CBTs without any affect on students' performance.
  • Doctoral Thesis
    Organik Çözücülerle Karbonil Sülfit Yakalamanın Teorik Olarak İncelenmesi
    (2021) Abduesslam, Mahmoud; Yaman, Şeniz Özalp; Kayı, Hakan
    Kimya mühendisleri, endüstriyel gazlardaki karbonil sülfitin (COS) varlığına odaklanırlar ve ayrıca sıvılaştırılmış petrol gazında COS'nin doğal oluşumlarını dikkate alırlar. Çevresel düzenlemelere uymak ve gaz dağıtım endüstrilerinin katı çevresel gereksinimlerini karşılamak için gaz akışlarındaki zehirli ve aşındırıcı özelliklere sahip tüm safsızlıklar temizlenmelidir. Reaktif soğurma, asit gazlarını gidermenin en güvenilir yollarından biri olarak kabul edildiğinden, aminler ve alkol karışımları kullanılarak asitleri gidermek için tipik olarak kullanılan bir tekniktir. Bu çalışmada, organik sıvı karışımları kullanılarak ωB97X-D3/6-311++G(d,p) teori düzeyinde yoğunluk fonksiyonel teorisi (DFT) hesaplamaları kullanılarak COS'nin yakalanması araştırılmıştır. Bu karışımlar, aminlerden, 1,8-diazabisiklo[5.4.0]undek-7-en (DBU), 1,5-diazabisiklo[4.3.0]non-5-en (DBN) ve 2-tert-bütil-1,1,3,3-tetrametilguanidin (BTMG) and 1, 5, 7-triazabicyclo [4.4.0] dec-5-ene (TBD)'den oluşmakta ve ayrıca bir dizi lineer alkol, yani metanol, etanol, 1-propanol, 1-butanol, 1-pentanol ve 1-hekzanol içermektedir. Çalışma boyunca, COS'un yakalanmasında 4 tip amin ile 6 tip alkol için modifiye edilmiş tek basamaklı bir termoleküler tepkime mekanizması incelenmiştir. Toplamda on sekiz farklı sistem araştırılmış ve önerilen COS yakalama tepkimelerinin termodinamiği ve kinetiği ile birlikte yapısal özellikleri ayrıntılı olarak ortaya konulmuştur. Sonuçlar, önerilen termoleküler tepkime mekanizmalarının test edilen 18 farklı sistem için termodinamik olarak uygulanabilir olduğunu ve BTMG ile metanolden oluşan organik sıvı kombinasyonunun, COS yakalamada en düşük enerji bariyeri ve en yüksek tepkime hızı ile sonuçlandığını gösterdi.
  • Article
    Citation - WoS: 14
    Citation - Scopus: 19
    Electrochemistry of nickel(II) complexes with <i>N</i>,<i>N</i>'-bis(3,5-di-<i>tert</i>-butylsalicylidene)polymethylenediamines
    (Pergamon-elsevier Science Ltd, 2005-10) Özalp-Yaman, S; Kasumov, VT; Önal, AM
    The electrochemical oxidation of several N,N'-polymethylenebis(3,5-di-tert- butylsalicylaldiminato)nickel(II) complexes, Ni(L-x), has been studied by cyclic voltammetry and in situ UV-Vis spectroscopy in DMF Cyclic voltammograms of Ni(L-x) (x = 1-4) complexes displayed two-step oxidation processes under nitrogen gas atmosphere. The first oxidation peak potentials of all the Ni(II) complexes corresponds to the reversible one-electron oxidation process of the metal center, yielding Ni(III) species. EPR spectrum of the electrolysis solution was recorded after one electron transfer at liquid nitrogen temperature also confirms the formation of [Ni-III (L-3)](+) species (g(x) > g(y) > g(z)) with a (2)A(1)(d(z)(2))(1) ground state. Upon addition of pyridine to one electron oxidised solutions a new penta coordinated species, [Ni-III(L-3)Py](+) (g(perpendicular to) > g(parallel to), a(parallel to)(N-14) = 8 G), was produced. The second oxidation peak of the complexes was assigned as the ligand based oxidation, generating a coordinated phenoxy radical species. (c) 2005 Elsevier Ltd. All rights reserved.
  • Article
    Citation - WoS: 16
    Citation - Scopus: 20
    Concise Synthesis, Electrochemistry and Spectroelectrochemistry of Phthalocyanines Having Triazole Functionality
    (Pergamon-elsevier Science Ltd, 2014-04) Karaca, Huseyin; Sezer, Serdar; Ozalp-Yaman, Seniz; Tanyeli, Cihangir
    The synthesis of novel metallophthalocyanines (M = Zn, Ni) bearing substituted benzyl protected 1,2,3-triazole moieties at peripheral positions is described for the first time via direct cyclotetramerization. These complexes have been characterized by a combination of FT-IR, H-1 NMR, HRMS and UVVis spectroscopy techniques and all the new compounds are highly soluble in most common organic solvents. In addition, the electrochemical and electrochromic behaviors of the complexes are investigated. Cyclic voltammetry and differential pulse voltammetry measurements demonstrate ligand base oxidations and reductions for both the Zn(II) and Ni(II) phthalocyanines by the transfer of one electron in each electrochemical step. The redox couples are identified in situ by monitoring the electronic absorption spectral changes during the electrolysis.
  • Article
    Citation - WoS: 13
    Electrochemical and Quantum Chemical Studies on Mitomycin and Adriamycin
    (Elsevier, 2003-06) Özalp-Yaman, S; Önal, AM; Türker, L
    In-situ spectroelectrochemical redox behaviour of two prominent chemotherapeutic agents, mitomycin and adriamycin were studied at constant potential. AM 1 (UHF) type quantum chemical calculations on the neutral as well as radical anion and cation forms of mitomycin and adriamycin were performed. (C) 2003 Elsevier Science B.V. All rights reserved.
  • Article
    Citation - WoS: 12
    Citation - Scopus: 13
    Novel Pt(ii) Complexes Containing Pyrrole Oxime, Synthesis, Characterization and Dna Binding Studies
    (Elsevier, 2014-05) Erdogan, Deniz Altunoz; Ozalp-Yaman, Seniz
    Since the discovery of anticancer activity and subsequent clinical success of cisplatin (cis-[PtCl2(NH3)(2)]), platinum-based compounds have since been widely synthesized and studied as potential chemotherapeutic agents. In this sense, three novel nuclease active Pt(II) complexes with general formula; [Pt(NH3)CI(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) in which L is 1-H-pyrrole-2-carbaldehyde oxime were synthesized. Characterization of complexes was performed by elemental analysis, FT-IR, H-1 NMR and mass spectroscopy measurements. Interaction of complexes (1-3) with calf thymus deoxyribonucleic acid (ct-DNA) was investigated by using electrochemical, spectroelectrochemical methods and cleavage studies. The hyperchromic change in the electronic absorption spectrum of the Pt(II) complexes indicates an electrostatic interaction between the complexes and ct-DNA. Binding constant values between 4.42 x 10(3) and 5.09 x 10(3) M-1 and binding side size values between 2 and 3 base pairs were determined from cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies. (C) 2014 Elsevier B.V. All rights reserved.
  • Article
    Citation - WoS: 41
    Citation - Scopus: 48
    Platinated Copper(3-Clip Complexes as Effective Dna-Cleaving and Cytotoxic Agents
    (Wiley-v C H verlag Gmbh, 2008-03-28) Ozalp-Yaman, Seniz; de Hoog, Paul; Amadei, Giulio; Pitie, Marguerite; Gamez, Patrick; Dewelle, Janique; Reedijk, Jan
    The synthesis and biological activity of three heteronuclear platinum-copper complexes based on 3-Clip-Phen are reported. These rigid complexes have been designed to alter the intrinsic mechanism of action of both the platinum moiety and the Cu(3-Clip-Phen) unit. The platinum centers of two of these complexes are coordinated to a 3-Clip-Phen moiety, an ammine ligand and two chlorides, which are either cis or trans to each other. The third complex comprises two 3-Clip-Phen units and two chloride ligands bound in a trans fashion to the platinum ion. DNA-cleavage experiments show that the complexes are highly efficient nuclease agents. In addition, a markedly difference in their aptitude to perform direct double-strand cleavage is observed, which appears to be strongly related to the ability of the platinum unit to coordinate to DNA. Indeed, complex 6 is unable to coordinate to DNA, which is reflected by its incapability to carry out double-strand breaks. Nonetheless, this complex exhibits efficient DNA-cleavage activity, and its cytotoxicity is high for several cell lines. Complex 6 shows better antiproliferate activity than both cisplatin and Cu(3-Clip-Phen) toward most cancer cell lines. Furthermore, the cytotoxicity observed for 1 is for most cell lines close to that of cisplatin, or even better. Cu(3-Clip-Phen) induces very low cytotoxic effects, but a marked migratory activity. Complex 6 presents DNA-cleavage properties comparable to the one of Cu(3-Clip-Phen), but it does not show any migratory activity. Interestingly, both Cu(3-Clip-Phen) and 6 induces vacuolisation processes in the cell in contrast to complex 1 and cisplatin. Thus, the four complexes cisplatin tested, Cu(3-Clip-Phen), I and 6 stimulate different cellular responses.
  • Article
    Paper-Based Versus Computer-Based Testing in Engineering Education
    (IEEE EDUCON Education Engineering 2010 – The Future of Global Learning Engineering Education, 2010) Çağıltay, Nergiz; Özalp Yaman, Şeniz
    Using computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil and computer-based test environments. Accordingly, more evidences are needed especially for the engineering education. In this study, students’ performance on different test modes was evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that, there is no significant performance difference between paper-and-pencil and computer based tests. By comparing results with the previous studies, this study concludes that, personal characteristics of test takers, the features of computer-based testing systems and the test content are all possible confounding factors when comparing test modes and need to be considered by the implementers. The results of this study show that, once these factors are controlled, students’ performance on computer-based tests and paper-and-pencil tests in chemistry courses for the engineering students will not vary. This finding is encouraging the educators to get benefits of computer-based tests without any affect on students’ performance.
  • Master Thesis
    N-(piridin-2-il) metilen benznamine içeren platin(II) kompleksinin sentezi, karakterizasyonu ve spektroskopik yöntemlerle DNA, HSA ve BSA'ya bağlanma davranımları
    (2017) Abdalla, Rema A İbrahim; Yaman, Şeniz Özalp; Özkan, Filiz Korkmaz
    Cisplatinin (Pt(NH3)2Cl2) yapısal analogları DNA ile benzer şekilde etkileştiği için, yeni platin temelli antitümör ilaçlarının, cisplatinden daha aktif olması ve çeşitli nedenlerle oluşabilecek ilaç direncini yenebilmesi beklenilmektedir. Bu amaçla, N-(piridin-2-il)metilen benzamin (L) ligandı içeren PtCl2 kompleksi sentezlenmiş ve karakterizasyonu tamamlanmıştır. Pt(L)Cl2 bileşiğinin buzağı DNA'sı ve serum albumin (BSA ve HSA) ile etkileşimleri test edilmiştir. Pt(L)Cl2 kompleksinin DNA'ya bağlanma mekanizmasını belirleyebilmek için çeşitli spektroskopik yöntemler kullanılmıştır. Platin kompleksi varlığında DNA çözeltisi ile gerçekleştirilen elektronik soğurma spektrumu, termal davranım, viskosite ölçümleri ve florometrik titrasyon deneyleri Pt(L)Cl2'nin DNA ile elektrostatik etkileşim yaptığını kanıtlamıştır. Aynı şekilde, spektroskopik ve viskometrik bulgular Pt(L)Cl2'nin serum proteinleri ile elektrostatik olarak etkileştiğini göstermiştir. Etkileşimin her iki protein için de hidrofobik bölgede olduğu, triptofan etrafında hidrofilite artışı ve alfa heliksler etrafında hidrofilite artışı ile ortaya konulmuştur. Öte yandan sürdürülen detaylı FTIR ölçümlerinden Pt(L)Cl2'nin BSA ya da HSA ile etkileşim noktası husunda net bir bilgi edinilememiştir.