Özalp Yaman, Şeniz
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Name Variants
Ozalp Yaman,Ş.
Ozalp Yaman, Seniz
Ş.,Özalp Yaman
S.,Ozalp Yaman
Şeniz Özalp Yaman
O., Seniz
O. Y. Seniz
Ozalp Yaman,S.
Ozalp Yaman,Seniz
O.,Seniz
Seniz, Ozalp Yaman
Şeniz, Özalp Yaman
Ö., Şeniz
Ö.Y.Şeniz
Ö. Y. Şeniz
Özalp Yaman Ş.
Özalp Yaman,Ş.
S., Ozalp Yaman
Ş., Özalp Yaman
Ö.,Şeniz
Özalp Yaman, Şeniz
Ozalp-Yaman, Seniz
Yaman, Seniz-Ozalp
Yaman, Şeniz Özalp
Özalp-Yaman, S
Oezalp-Yaman, Seniz
Özalp-Yaman,Ş.
Yaman,Ş.Ö.
Ozalp Yaman, Seniz
Ş.,Özalp Yaman
S.,Ozalp Yaman
Şeniz Özalp Yaman
O., Seniz
O. Y. Seniz
Ozalp Yaman,S.
Ozalp Yaman,Seniz
O.,Seniz
Seniz, Ozalp Yaman
Şeniz, Özalp Yaman
Ö., Şeniz
Ö.Y.Şeniz
Ö. Y. Şeniz
Özalp Yaman Ş.
Özalp Yaman,Ş.
S., Ozalp Yaman
Ş., Özalp Yaman
Ö.,Şeniz
Özalp Yaman, Şeniz
Ozalp-Yaman, Seniz
Yaman, Seniz-Ozalp
Yaman, Şeniz Özalp
Özalp-Yaman, S
Oezalp-Yaman, Seniz
Özalp-Yaman,Ş.
Yaman,Ş.Ö.
Job Title
Profesör Doktor
Email Address
seniz.ozalpyaman@atilim.edu.tr
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Scholarly Output
37
Articles
25
Citation Count
449
Supervised Theses
10
36 results
Scholarly Output Search Results
Now showing 1 - 10 of 36
Article Citation Count: 2Spectroelectrochemical investigations of pyrimidine-2-thionato-bridged binuclear platinum(III) complexes(Pergamon-elsevier Science Ltd, 2014) Ozbek, Ozge; Ozalp-Yaman, Seniz; Ozkan, Ilker; Onal, Ahmet M.; Isci, Huseyin; Chemical EngineeringThe electrochemical behavior of the binuclear platinum(III-III) complexes [Pt-2(C4H3N2S)(4)X-2] (C4H3N2S- = pyrimidine-2-thionate; X- = Cl--,Cl- Br--,Br- I-) have been studied by cyclic voltammetry and insitu spectroelectrochemistry in an acetonitrile-tetrabutylammonium tetrafluoroborate solventelectrolyte couple. An irreversible metal based reduction appears during the cathodic scan for each of the three complexes. The changes in UV-Vis spectra observed in-situ during the reductive electrolysis indicate that all three complexes give the same product, [Pt-2(C4H3N2S)(4)], with a Pt(II)-Pt(II) system. The changes in the reduction potentials of the complexes on changing the axial ligands are interpreted by the changes in the energy of the LUMO level, which is determined by the degree of sigma- and it-interactions of the axial halide ligands with the metal atoms. DFT (B3LYP/LanL2DZ) calculations support our experimental data. (c) 2014 Elsevier Ltd. All rights reserved.Article Citation Count: 37Synthesis, spectroscopy and electrochemical behaviors of nickel(II) complexes with tetradentate shiff bases derived from 3,5-Bu2t-salicylaldehyde(Pergamon-elsevier Science Ltd, 2005) Kasumov, VT; Özalp-Yaman, S; Tas, E; Chemical EngineeringNickel(II) complexes of a series of N,N'-polymethylenebis(3,5-Bu'(2)-salicylaidimine) ligands containing 2,4-di-Bu'(2)-phenol arms, NiLx, were synthesized and their spectroscopic and redox properties were examined. The UV-vis, H-1 NMR spectroscopic and magnetic results indicate that complexes NiL1-NiL4 unlike NiL5 and NiL6 have a square-planar structure in the solid state and in solution. Cyclic voltammograms of NiLx (x= 1-4) complexes displayed two-step oxidation processes. The first oxidation peak potentials of all Ni(II) complexes corresponds to the reversible one-electron oxidation process of the metal center, yielding Ni(III) species. The second oxidation peak of the complexes was assigned as the ligand based oxidation generating a coordinated phenoxyl radical species. (c) 2005 Elsevier B.V. All rights reserved.Article Citation Count: 3Anticancer investigation of platinum and copper-based complexes containing quinoxaline ligands(Elsevier, 2022) El-Beshti, Hager Sadek; Yildizhan, Yasemin; Kayi, Hakan; Cetin, Yuksel; Adiguzel, Zelal; Gungor-Topcu, Gamze; Ozalp-Yaman, Seniz; Chemical EngineeringThis research focuses on synthesis and anticancer activity of trans-[(dichloro)bisdipyridlquinoxalino] and [(dichloro)bisdithienylquinoxalino]copper(II)/platinum(II) compounds as prodrug candidates. The binding interaction of these compounds with calf thymus DNA (CT-DNA) and human serum albumin (HSA) of the complexes were assessed with UV titration, thermal decomposition, viscometric, and fluorometric measurements. The nature of the binding of the complexes on DNA were revealed as electrostatic interaction between the cationic metal complexes ion and the negative phosphate groups of CT-DNA upon removal of the counter ion, chloride. In addition, our complexes induced a surface contact through the hydrophobic region of protein. Antitumor activity of the complexes against human glioblastoma A172, LN229, and U87 cell lines and human lung A549, human breast MDA-231, human cervix HeLa, and human prostate PC-3 cell lines were investigated by examining cell viability, oxidative stress, apoptosis, and migration/invasion. Cytotoxicity of the complexes was evaluated by MTT test. The U87 and HeLa cells were investigated as the cancer cells most sensitive to our complexes. The exerted cytotoxic effect of dipyridlquinoxalino and dithienylquinoxalino copper(II)/platinum(II) complexes was attributed to the formation of the reactive oxygen species in vitro. It is clearly demonstrated that trans-[(dichloro)bisdithenylquinoxalino]copper (II) (Cu(dtq)) has the highest DNA degradation potential and anticancer effect among the tested complexes by leading apoptosis. Wound healing and invasion analysis results also supported the anticancer activity of Cu(dtq). (C) 2021 Elsevier B.V. All rights reserved.Article Citation Count: 2Electrochemistry of acetate-, carbonate-, sulfate-, and dihydrogenphosphate-bridged dirhodium(II) complexes(Verlag der Zeitschrift fur Naturforschung, 2003) Yaman,Ş.Ö.; Önal,A.M.; Isci,H.; Chemical EngineeringComplexes, [Rh2(B-B)4L2]n (B-B = CH3CO2-, L = CH3CN, H2O, Cl-, Br-, SCN-; B-B = CO32-, SO42-, H2PO4-, L = H2O, Cl-, Br-, SCN-) were prepared and their cyclic voltammograms (CV) and electronic absorption spectra were measured in solution. The CV of the complexes exhibits a reversible one-electron transfer from a metal-based orbital. Constant potential electrolysis at the oxidation peak potential of [Rh2 (O2CCH3)4 (NCCH3)2] in acetonitrile yielded [Rh2 (O2CCH3)4 (NCCH3)2]+, a mixed valent Rh(II)-Rh(III) cation complex. The formation of the mixed valent complex was monitored by measuring electronic absorption spectra of the solution in situ during the oxidative electrolysis. The reductive electrolysis of the mixed valent complex solution, in the same electrolysis cell, yielded the original electronic absorption spectrum of the starting complex. The changes in the oxidation and reduction potentials of the complexes with different axial ligands, L = H2O, Cl-, Br-, SCN-, are correlated to the relative energy changes of HOMO and LUMO of the complexes, which indicates the metal-axial ligand σ- and π-bonding interactions. Spectroscopic and CV data indicate that the degree of σ-interaction is Cl- > Br- > SCN-, and that of π-interaction is Br- > SCN- > Cl-.Article Citation Count: 6A platinum blue complex exerts its cytotoxic activity via DNA damage and induces apoptosis in cancer cells(Wiley, 2017) Adiguzel, Zelal; Ozalp-Yaman, Seniz; Celik, Gokalp; Salem, Safia; Bagci-Onder, Tugba; Senbabaoglu, Filiz; Acilan, Ceyda; Chemical EngineeringHere, we describe the characteristics of a Pt-blue complex [Pt-4(2-atp)(8)(H2O)(OH)] (2-atp: 2-aminothiophenol) as a prodrug for its DNA-binding properties and its use in cancer therapy. The nature of the interaction between the Pt-blue complex and DNA was evaluated based on spectroscopic measurements, the electronic absorption spectra, thermal behavior, viscosity, fluorometric titration, and agarose gel electrophoresis. Our results suggested that the compound was able to partially intercalate DNA and appeared to induce both single- and double-stranded breaks (DBS) on DNA in vitro, but no DSBs in cells. The ability of the compound to induce DNA damage was dependent on reactive oxygen species (ROS) in vitro. There was also elevated formation of ROS and SOD expression in response to drug treatment in cell culture. The complex was found to be more cytotoxic to cancer cells in comparison with noncancer controls using WST-1 assay. The mean of cell death was determined to be apoptosis as assessed via biochemical, morphological, and molecular observations, including DNA condensation/fragmentation analysis, live cell imaging microscopy, TUNEL analyses, and increase in the levels of pro-apoptotic genes such as Bag3, Bak, Bik, Bmf, and Hrk. Hence, the Pt-blue complex under study grants premise for further studies.Article Citation Count: 43Platinated copper(3-clip-phen) complexes as effective DNA-cleaving and cytotoxic agents(Wiley-v C H verlag Gmbh, 2008) Ozalp-Yaman, Seniz; de Hoog, Paul; Amadei, Giulio; Pitie, Marguerite; Gamez, Patrick; Dewelle, Janique; Reedijk, Jan; Chemical EngineeringThe synthesis and biological activity of three heteronuclear platinum-copper complexes based on 3-Clip-Phen are reported. These rigid complexes have been designed to alter the intrinsic mechanism of action of both the platinum moiety and the Cu(3-Clip-Phen) unit. The platinum centers of two of these complexes are coordinated to a 3-Clip-Phen moiety, an ammine ligand and two chlorides, which are either cis or trans to each other. The third complex comprises two 3-Clip-Phen units and two chloride ligands bound in a trans fashion to the platinum ion. DNA-cleavage experiments show that the complexes are highly efficient nuclease agents. In addition, a markedly difference in their aptitude to perform direct double-strand cleavage is observed, which appears to be strongly related to the ability of the platinum unit to coordinate to DNA. Indeed, complex 6 is unable to coordinate to DNA, which is reflected by its incapability to carry out double-strand breaks. Nonetheless, this complex exhibits efficient DNA-cleavage activity, and its cytotoxicity is high for several cell lines. Complex 6 shows better antiproliferate activity than both cisplatin and Cu(3-Clip-Phen) toward most cancer cell lines. Furthermore, the cytotoxicity observed for 1 is for most cell lines close to that of cisplatin, or even better. Cu(3-Clip-Phen) induces very low cytotoxic effects, but a marked migratory activity. Complex 6 presents DNA-cleavage properties comparable to the one of Cu(3-Clip-Phen), but it does not show any migratory activity. Interestingly, both Cu(3-Clip-Phen) and 6 induces vacuolisation processes in the cell in contrast to complex 1 and cisplatin. Thus, the four complexes cisplatin tested, Cu(3-Clip-Phen), I and 6 stimulate different cellular responses.Article Citation Count: 0ANN-assisted forecasting of adsorption efficiency to remove heavy metals(Tubitak Scientific & Technological Research Council Turkey, 2019) Buaısha, Magdi; Balku, Şaziye; Yaman, Şeniz Özalp; Energy Systems Engineering; Chemical EngineeringIn wastewater treatment, scientific and practical models utilizing numerical computational techniques suchas artificial neural networks (ANNs) can significantly help to improve the process as a whole through adsorption systems.In the modeling of the adsorption efficiency for heavy metals from wastewater, some kinetic models have been used such as pseudo first-order and second-order. The present work develops an ANN model to forecast the adsorption efficiency of heavy metals such as zinc, nickel, and copper by extracting experimental data from three case studies. To do this, we apply trial-and-error to find the most ideal ANN settings, the efficiency of which is determined by mean square error (MSE) and coefficient of determination (R2). According to the results, the model can forecast adsorption efficiency percent (AE%) with a tangent sigmoid transfer function (tansig) in the hidden layer with 10 neurons and a linear transferfunction (purelin) in the output layer. Furthermore, the Levenberg–Marquardt algorithm is seen to be most ideal for training the algorithm for the case studies, with the lowest MSE and high R2 . In addition, the experimental results and the results predicted by the model with the ANN were found to be highly compatible with each other.Article Citation Count: 14How can we get benefits of computer-based testing in engineering education?(Wiley, 2013) Cagiltay, Nergiz; Yaman, Seniz-Ozalp; Software Engineering; Chemical EngineeringUsing computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil (P&P) and computer-based test (CBT) environments. Additionally, these studies fail to address the engineering domain. Our main assumption is that, if we could define the confounding factors to satisfy that these two versions of the tests provide equivalent results, then especially in the first year courses of the engineering education programs, we could get several benefits of the CBT environments. Accordingly, in this study, students' performance on different test modes was evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that there is no significant performance difference between P&P and CBT. By comparing results with the previous studies, this study concludes that personal characteristics of test takers, the features of CBT systems, and the test content are all possible confounding factors when comparing test modes and need to be considered by the implementers. The results of this study show that once these factors are controlled, students' performance on CBTs and P&P tests in chemistry courses will not vary. This finding is encouraging the educators to get benefits of CBTs without any affect on students' performance. (c) 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 21: 287293, 2013; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.20470Conference Object Citation Count: 8Paper-based versus computer-based testing in engineering education(2010) Özalp-Yaman,Ş.; Çaǧiltay,N.E.; Chemical EngineeringUsing computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil and computer-based test environments. Accordingly, more evidences are needed especially for the engineering education. In this study, students' performance on different test modes was evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that, there is no significant performance difference between paper-and-pencil and computer based tests. By comparing results with the previous studies, this study concludes that, personal characteristics of test takers, the features of computer-based testing systems and the test content are all possible confounding factors when comparing test modes and need to be considered by the implementers. The results of this study show that, once these factors are controlled, students' performance on computer-based tests and paper-and-pencil tests in chemistry courses for the engineering students will not vary. This finding is encouraging the educators to get benefits of computer-based tests without any affect on students' performance © 2010 IEEE.Article How Can We Get Benefits of Computer-Based Testing in Engineering Education?(Computer Applications in Engineering Education, 2010) Çağıltay, Nergiz; Özalp Yaman, Şeniz; Chemical Engineering; Software EngineeringUsing computers for assessment can provide several benefits for educators and test-takers. However, in the literature, there is no consensus on the equivalence of paper-and-pencil (P&P) and computer-based test (CBT) environments. Additionally, these studies fail to address the engineering domain. Our main assumption is that, if we could define the confounding factors to satisfy that these two versions of the tests provide equivalent results, then especially in the first year courses of the engineering education programs, we could get several benefits of the CBT environments. Accordingly, in this study, students' performance o different test modes waws evaluated on 209 first year engineering students of a chemistry course. The results of this study showed that there is no significant performance difference between P&P and CBT. By comparing results with the previous studies, this study concludes that personal characteristics of test talers, the features of CBT systems, and the test content are all possible confounding factors when comparing test modes anf need to be considered by the implementers. The results of this study show that once these factors are controlled, students' performance on CBTs and P&P tests in chemistry courses will not vary. This finding is encourging the educators to get benefits of CBTs without any affect on students' performance.
