A Novel Technique- Subendometrial Autologous Platelet Rich Plasma Injection in Patients With Unresponsive Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: a Prospective Cohort Study

dc.authorscopusid 12773070800
dc.authorscopusid 55834891800
dc.authorscopusid 57217331404
dc.authorscopusid 57217331629
dc.authorscopusid 58284385800
dc.authorscopusid 55680866700
dc.authorscopusid 7003951918
dc.contributor.author Cakiroglu, Yigit
dc.contributor.author Tohma, Yusuf Aytac
dc.contributor.author Yuceturk, Aysen
dc.contributor.author Karaosmanoglu, Ozge
dc.contributor.author Aslan, Ilke Ozer
dc.contributor.author Kopuk, Sule Yildirim
dc.contributor.author Tiras, Bulent
dc.date.accessioned 2025-04-07T18:53:12Z
dc.date.available 2025-04-07T18:53:12Z
dc.date.issued 2025
dc.department Atılım University en_US
dc.department-temp [Cakiroglu, Yigit; Tiras, Bulent] Acibadem Mehmet Ali Aydinlar Univ, Dept Obstet & Gynecol, Istanbul, Turkiye; [Cakiroglu, Yigit; Yuceturk, Aysen; Karaosmanoglu, Ozge; Aslan, Ilke Ozer; Tiras, Bulent] Acibadem Maslak Hosp, Assisted Reprod Technol Unit, Istanbul, Turkiye; [Tohma, Yusuf Aytac] Bahceci Saglik Grubu, Bahceci Ankara Tup Bebek Merkezi, Ankara, Turkiye; [Tohma, Yusuf Aytac] Atilim Univ, Fac Med, Dept Obstet & Gynecol, Ankara, Turkiye; [Kopuk, Sule Yildirim] VM Med Pk Pendik Hosp, Assisted Reprod Technol Unit, Istanbul, Turkiye; [Korun, Zeynep Ece Utkan] Yeditepe Univ, Dept Obstet & Gynecol, Istanbul, Turkiye; [Yazicioglu, Caglar] Acibadem Int Hosp, Istanbul, Turkiye; [Zeyneloglu, Hulusi Bulent] Femart Clin, Ankara, Turkiye en_US
dc.description.abstract Background The purpose of this study was to investigate the effects of subendometrial PRP injection on endometrial thickness and pregnancy outcomes in patients with a history of unresponsive thin endometrium undergoing frozen-thawed embryo transfer (FET). Methods This prospective cohort study was conducted at Acibadem Mehmet Ali Aydinlar University-Istanbul, Turkey. Women with a history of suboptimal endometrial proliferation (< 7 mm) were offered to participate in the study. Group 1 consisted of 100 individuals who consented to subendometrial PRP injection, while Group 2 consisted of 100 individuals who did not accept PRP injection. Within ten days of the menstrual cycle ending, autologous PRP was produced by centrifuging peripheral blood and administered transvaginally into the subendometrial region under ultrasound monitoring. After the PRP procedure, 14 days of oral estradiol supplementation were started as part of the hormonal treatment on the 2-4th day of the second menstrual cycle. Women determined to have adequate endometrial thickness following the initiation were scheduled for embryo transfers. Embryo transfer was scheduled for women who were found to have adequate endometrial thickness after the initiation of progesterone. Pregnancy (positive serum hCG) and livebirth rates were followed. Results A total of 200 women (age 36.4 +/- 5.8) were included in the study. Endometrial thickness increased after PRP therapy as compared to the control group (7.7 +/- 1.9 mm vs. 6.1 +/- 1.2 mm; p < 0.01). Three women (3.0%) in the PRP group conceived spontaneously, whereas 97 women (97.0%) attempted FET; no spontaneous pregnancies occurred in the control group. Compared to 75/100 (75% of the total) in the control group, 33/97 women (34.0%) in the PRP group were unable to undertake ET because of persistently unresponsive thin endometrium or fluid in the endometrial cavity (p < 0.001). The PRP group had a considerably higher percentage of positive serum hCG tests than the control group (25.8% vs. 9.0%; p = 0.002). Additionally, the PRP group had a higher clinical pregnancy rate (22.7% vs. 7.0%; p = 0.002). The live birth rate was significantly higher in the PRP group than the controls (17.5% vs. 2.0%; p < 0.001). Conclusions In women with a history of suboptimal endometrial development, subendometrial PRP injection was associated with improved endometrial thickness and livebirth rate. en_US
dc.description.woscitationindex Science Citation Index Expanded
dc.identifier.doi 10.1186/s12884-025-07400-x
dc.identifier.issn 1471-2393
dc.identifier.issue 1 en_US
dc.identifier.pmid 40098101
dc.identifier.scopus 2-s2.0-105000290420
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.1186/s12884-025-07400-x
dc.identifier.uri https://hdl.handle.net/20.500.14411/10511
dc.identifier.volume 25 en_US
dc.identifier.wos WOS:001447020900003
dc.identifier.wosquality Q2
dc.language.iso en en_US
dc.publisher BMC en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 1
dc.subject Thin Endometrium en_US
dc.subject Endometrial Prp en_US
dc.subject Frozen Embryo Transfer en_US
dc.title A Novel Technique- Subendometrial Autologous Platelet Rich Plasma Injection in Patients With Unresponsive Thin Endometrium Undergoing Frozen-Thawed Embryo Transfer: a Prospective Cohort Study en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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