Physico-chemical characterization and in vitro biological study of manganese doped β-tricalcium phosphate-based ceramics for bone regeneration applications
dc.authorid | Stan, George E./0000-0003-0289-8988 | |
dc.authorid | Gunduz, Oguzhan/0000-0002-9427-7574 | |
dc.authorscopusid | 58249501000 | |
dc.authorscopusid | 15836431700 | |
dc.authorscopusid | 55571996100 | |
dc.authorscopusid | 57204432022 | |
dc.authorscopusid | 16680382000 | |
dc.authorscopusid | 6603136021 | |
dc.authorscopusid | 58248563400 | |
dc.authorwosid | Stan, George E./B-5690-2011 | |
dc.authorwosid | Gunduz, Oguzhan/E-5292-2011 | |
dc.authorwosid | Trinca, Liliana Marinela/E-7100-2014 | |
dc.contributor.author | Şaşmazel, Hilal Türkoğlu | |
dc.contributor.author | Daglilar, Sibel | |
dc.contributor.author | Kalkandelen, Cevriye | |
dc.contributor.author | Balescu, Liliana-Marinela | |
dc.contributor.author | Sasmazel, Hilal Turkoglu | |
dc.contributor.author | Pasuk, Iuliana | |
dc.contributor.author | Gunduz, Oguzhan | |
dc.contributor.other | Metallurgical and Materials Engineering | |
dc.date.accessioned | 2024-07-05T15:25:10Z | |
dc.date.available | 2024-07-05T15:25:10Z | |
dc.date.issued | 2023 | |
dc.department | Atılım University | en_US |
dc.department-temp | [Arpak, Mehmet Can; Daglilar, Sibel] Yildiz Tech Univ, Fac Chem & Met Engn, Dept Met & Mat Engn, TR-34220 Istanbul, Turkiye; [Kalkandelen, Cevriye; Gunduz, Oguzhan] Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkiye; [Kalkandelen, Cevriye] Istanbul Univ Cerrahpasa, Vocat Sch Tech Sci, Biomed Devices Technol Dept, TR-34500 Istanbul, Turkiye; [Balescu, Liliana-Marinela; Pasuk, Iuliana; Stan, George E.] Natl Inst Mat Phys, Magurele 077125, Romania; [Sasmazel, Hilal Turkoglu; Durukan, Kagan] Atilim Univ, Fac Engn, Met & Mat Engn Dept, TR-06830 Ankara, Turkiye; [Gunduz, Oguzhan] Marmara Univ, Fac Technol, Dept Met & Mat Engn, TR-34722 Istanbul, Turkiye | en_US |
dc.description | Stan, George E./0000-0003-0289-8988; Gunduz, Oguzhan/0000-0002-9427-7574; | en_US |
dc.description.abstract | This work evaluates the effects of manganese (Mn) doping on the morpho-structural features, mechanical performance, and in vitro biological response of beta-tricalcium phosphate (beta-TCP) derived bioceramics for bone tissue engineering applications. Five different Mn doping levels (i.e., 0.01%, 0.05%, 0.1%, 0.5%, and 1 wt.%) were investigated, with the beta-TCP-based bioceramics being sintered at four temperatures (i.e., 1000, 1100, 1200, and 1300 degrees C). A densification improvement was induced when using Mn in excess of 0.05 wt.%; the densification remained stationary in the sintering temperature range of 1200 - 1300 degrees C. The structural analyses evidenced that all samples sintered at 1000 and 1100 degrees C were composed of beta-TCP as major phase and hydroxyapatite (HA) as a minor constituent (similar to 4-6 wt.%). At the higher temperatures (1200 and 1300 degrees C), the formation of alpha-TCP was signalled at the expense of both beta-TCP and HA. The Mn doping was evidenced by lattice parameters changes. The evolution of the phase weights is linked to a complex inter-play between the capacity of the compounds to incorporate Mn and the thermal decomposition kinetics. The Mn doping induced a reduction in the mechanical performance (in terms of compressive strength, Vickers hardness and elastic modulus) of the beta-TCP-based ceramics. The metabolic activity and viability of osteoblastic cells (MC3T3-E1) for the ceramics were studied in both powder and compacted pellet form. Ceramics with Mn doping levels lower than 0.1 wt.% yielded a more favorable microenvironment for the osteoblast cells with respect to the undoped beta-TCP. No cytotoxic effects were recorded up to 21 days. The Mn-doped beta-TCPs showed a significant increase (p < 0.01) in alkaline phosphatase activity with respect to pure beta-TCP. | en_US |
dc.description.sponsorship | Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI [PNIII-P1-1.1-TE-2019-0463]; Romanian Ministry of Research, Innovation and Digitalization; [PC2-PN23080101] | en_US |
dc.description.sponsorship | G.E.S. and L.M.B. are thankful for the financial support of the Romanian National Authority for Scientific Research and Innovation, CNCS-UEFISCDI, in the framework of PNIII-P1-1.1-TE-2019-0463 project (within PNCDI III), as well as to Core Program of the National Institute of Materials Physics within the National Research Development and Innovation Plan 2022-2027, carried out with the support of the Romanian Ministry of Research, Innovation and Digitalization under the project PC2-PN23080101. | en_US |
dc.identifier.citation | 1 | |
dc.identifier.doi | 10.1007/s41779-023-00889-5 | |
dc.identifier.endpage | 983 | en_US |
dc.identifier.issn | 2510-1560 | |
dc.identifier.issn | 2510-1579 | |
dc.identifier.issue | 4 | en_US |
dc.identifier.scopus | 2-s2.0-85159305398 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 969 | en_US |
dc.identifier.uri | https://doi.org/10.1007/s41779-023-00889-5 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14411/2516 | |
dc.identifier.volume | 59 | en_US |
dc.identifier.wos | WOS:000988194100001 | |
dc.identifier.wosquality | Q2 | |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Manganese doping | en_US |
dc.subject | beta-tricalcium phosphate | en_US |
dc.subject | Physical-chemical properties | en_US |
dc.subject | Rietveld XRD analysis | en_US |
dc.subject | Cytocompatibility | en_US |
dc.title | Physico-chemical characterization and in vitro biological study of manganese doped β-tricalcium phosphate-based ceramics for bone regeneration applications | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
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