Investigation of Hepatitis E Virus Seroprevalence and Risk Factors in Hemodialysis Patients

dc.authorscopusid 59696405300
dc.authorscopusid 56715463300
dc.authorscopusid 57225935503
dc.authorscopusid 58985979600
dc.authorscopusid 7004038581
dc.authorscopusid 8632573400
dc.authorscopusid 56088420500
dc.authorwosid Çifci Or Çiftçi, Aydın/Aby-5105-2022
dc.authorwosid Tuna, Ayşegül/Jvz-3579-2024
dc.contributor.author Ozturk, Hakki
dc.contributor.author Ozsoy, Metin
dc.contributor.author Tuna, Aysegul
dc.contributor.author Varlibas, Artuner
dc.contributor.author Cesur, Salih
dc.contributor.author Aksoy, Altan
dc.contributor.author Demir, Mehmet Emin
dc.date.accessioned 2025-06-05T21:18:44Z
dc.date.available 2025-06-05T21:18:44Z
dc.date.issued 2025
dc.department Atılım University en_US
dc.department-temp [Ozturk, Hakki; Cesur, Salih] Private Balgat Dialysis Ctr, Infect Dis Epidemiol, Ankara, Turkiye; [Ozsoy, Metin] Hlth Sci Univ, Ankara Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Ankara, Turkiye; [Tuna, Aysegul] Kirikkale Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Kirikkale, Turkiye; [Varlibas, Artuner; Cifci, Aydin] Kirikkale Univ, Fac Med, Dept Internal Med, Kirikkale, Turkiye; [Aksoy, Altan] Ankara Bilkent City Hosp, Dept Med Microbiol, Ankara, Turkiye; [Demir, Mehmet Emin] Atilim Univ, Ankara, Turkiye en_US
dc.description.abstract Background: Hemodialysis patients are at increased risk for hepatitis E virus (HEV) infection due to their immunocompromised status and frequent exposure to invasive medical procedures. HEV can lead to chronic infections and severe complications, particularly in high-risk populations. This study aimed to determine HEV-IgG seroprevalence among hemodialysis patients in Ankara, Turkey, and evaluate associated risk factors. Methods: A total of 160 hemodialysis patients from three private dialysis centers in Ankara were included in this prospective, cross-sectional study. Anti-HEV-IgG antibodies were detected using the ELISA method. Demographic characteristics and potential risk factors, including dialysis duration, comorbidities, blood transfusion history, drinking water source, dietary habits, and involvement in animal husbandry, were assessed via structured surveys. Statistical analyses were conducted using SPSS Version 22.0, with Pearson's chi-square and Fisher's exact tests applied to categorical variables. Logistic regression analysis was performed to identify independent risk factors for HEV seropositivity. Results: HEV-IgG seropositivity was detected in 42 patients (26.25%). Seroprevalence increased significantly with age, rising from 6.7% in patients under 55 years to 47.4% in those over 65 years (p < 0.001). Extended dialysis duration (>5 years) was also significantly associated with HEV seropositivity (p = 0.02). However, no significant associations were found between HEV seropositivity and gender, blood transfusion history, source of drinking water, consumption of raw meat, or involvement in animal husbandry (p > 0.05). Conclusion: The HEV-IgG seroprevalence among hemodialysis patients in Ankara was higher than previously reported rates in Turkey. Age and prolonged dialysis duration emerged as significant risk factors, underscoring the importance of screening and preventive strategies in this vulnerable population. Further multi-regional studies are needed to better understand HEV transmission dynamics and improve management strategies in hemodialysis patients. en_US
dc.description.woscitationindex Science Citation Index Expanded - Social Science Citation Index
dc.identifier.doi 10.3389/fpubh.2025.1574361
dc.identifier.issn 2296-2565
dc.identifier.pmid 40416665
dc.identifier.scopus 2-s2.0-105005991782
dc.identifier.scopusquality Q2
dc.identifier.uri https://doi.org/10.3389/fpubh.2025.1574361
dc.identifier.uri https://hdl.handle.net/20.500.14411/10604
dc.identifier.volume 13 en_US
dc.identifier.wos WOS:001493222300001
dc.identifier.wosquality Q1
dc.language.iso en en_US
dc.publisher Frontiers Media Sa en_US
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.scopus.citedbyCount 0
dc.subject Hepatitis E Virus en_US
dc.subject Hemodialysis en_US
dc.subject Seroprevalence en_US
dc.subject Risk Factors en_US
dc.subject Immunosuppression en_US
dc.title Investigation of Hepatitis E Virus Seroprevalence and Risk Factors in Hemodialysis Patients en_US
dc.type Article en_US
dc.wos.citedbyCount 0
dspace.entity.type Publication

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